{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T05:05:14Z","timestamp":1779771914602,"version":"3.53.1"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Malnutrition and sarcopenia are prevalent among patients with gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), necessitating simple assessment tools to identify potentially malnourished patients. After describing the nutritional status of those receiving anticancer treatment in Spain, the development of a nutrition screening tool for GEP-NENs was proposed as an exploratory objective of the NUTRIGETNE study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Malnutrition was defined by Global Leadership Initiative on Malnutrition (GLIM) criteria. Sarcopenia by European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria. Patients were randomized 4:1 into training and validation sets to build a least absolute shrinkage and selection operator (LASSO) model. The model was corrected by sex, age, and body mass index. Predictors selected according to the area under the curve criterion were then used to fit the optimal model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>This study included 399 patients. Most had grade 1 or 2 (86.2%) tumors, originating mostly in the small intestine (43.9%) and pancreas (41.6%). Prevalence of malnutrition and sarcopenia was 61.9 and 15%, respectively. The predictive model had an external accuracy of 65.3 and 71.2% for malnutrition and sarcopenia, respectively. The stronger predictive factors for malnutrition were poor tumor differentiation (odds ratio [OR]: 4.4; 95% confidence interval [CI]: 1.2\u201322), nausea\/vomiting (OR: 3.4; 95% CI: 1.4\u20139.3), having difficulties for a long walk (OR: 3; 95% CI: 1.8\u20135) and diabetes (OR: 2.2; 95% CI: 1.3\u20133.9). Sarcopenia was correlated with having troubles in activities of daily living (OR: 19.7; 95% CI: 3.1\u2013390.9), or difficulties for a long walk (OR: 6.1; 95% CI: 2.6\u201315.5).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A nomogram based on these models was developed. We generated a diagnostic tool for malnutrition and sarcopenia in patients with GEP-NENs to identify high-risk cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1789458","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T04:39:31Z","timestamp":1779770371000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A prediction tool for malnutrition and sarcopenia in patients with gastroenteropancreatic neuroendocrine neoplasms: results from NUTRIGETNE (GETNE-S2109) study"],"prefix":"10.3389","volume":"13","author":[{"given":"Maria","family":"Argente-Pla","sequence":"first","affiliation":[{"name":"Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia-Health Research Institute La Fe","place":["Valencia, Spain"]},{"name":"Department of Endocrinology and Nutrition, University and Polytechnic Hospital La Fe","place":["Valencia, Spain"]},{"name":"Department of Medicine, Faculty of Medicine, University of Valencia","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel Antonio","family":"Sampedro-Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital de La Princesa","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio","family":"Garcia-Carbonero","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Universitario 12 de Octubre, Imas12, Facultad de Medicina, UCM","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Custodio","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Universitario La Paz, Instituto de Investigaci\u00f3n Biom\u00e9dica Hospital Universitario La Paz (IdiPAZ)","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Hernando","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Vall Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO)","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Suarez","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Nutrition, Hospital Universitario Central de Asturias, Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias (ISPA)","place":["Oviedo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Hernandez-Rienda","sequence":"additional","affiliation":[{"name":"Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia-Health Research Institute La Fe","place":["Valencia, Spain"]},{"name":"Department of Endocrinology and Nutrition, University and Polytechnic Hospital La Fe","place":["Valencia, Spain"]},{"name":"Department of Medicine, Faculty of Medicine, University of Valencia","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Peir\u00f3","sequence":"additional","affiliation":[{"name":"Clinical Nutrition Unit, Institut Catal\u00e0 d'Oncologia (ICO), l'Hospitalet de Llobregat","place":["l'Hospitalet de Llobregat, Spain"]},{"name":"Bellvitge Biomedical Research Institute (IDIBELL)","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Alonso","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Instituto Aragones de Investigacion Sanitaria, Hospital Universitario Miguel Servet","place":["Zaragoza, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Serrano","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Universitario Reina Sof\u00eda, Instituto Maimonides de Investigaci\u00f3n Biomedica (IMIBIC)","place":["C\u00f3rdoba, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Vald\u00e9s","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, University Hospital Cruces, Bilbao, Biobizkaia, CIBERDEM\/CIBERER, EndoERN, UPV\/EHU","place":["Barakaldo, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Melian","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Instituto Valenciano de Oncolog\u00eda (IVO)","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Febrero","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery, General Surgery Service, Virgen de la Arrixaca University Hospital","place":["Murcia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josefina","family":"Biarnes","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Universitari de Girona Dr. Josep Trueta","place":["Girona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 \u00c1ngel","family":"D\u00edaz-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Hospital Universitario Cl\u00ednico San Carlos","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Molina-Cerrillo","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Universitario Ram\u00f3n y Cajal","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Lopez","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Hospital Universitario Marqu\u00e9s de Valdecilla, IDIVAL, UNICAN","place":["Santander, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Mart\u00ednez Olmos","sequence":"additional","affiliation":[{"name":"Endocrinology and Nutrition Department, Complejo Hospitalario Universitario de Santiago","place":["Santiago de Compostela (A Coru\u00f1a), Spain"]},{"name":"Molecular Endocrinology Group-Health Research Institute of Santiago de Compostela-IDIS","place":["Santiago de Compostela (A Coru\u00f1a), Spain"]},{"name":"CIBER de Fisiopatolog\u00eda de La Obesidad y Nutrici\u00f3n (CIBEROBN), Instituto de Salud Carlos III","place":["Madrid, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Merino-Torres","sequence":"additional","affiliation":[{"name":"Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia-Health Research Institute La Fe","place":["Valencia, Spain"]},{"name":"Department of Endocrinology and Nutrition, University and Polytechnic Hospital La Fe","place":["Valencia, Spain"]},{"name":"Department of Medicine, Faculty of Medicine, University of Valencia","place":["Valencia, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Capdevila","sequence":"additional","affiliation":[{"name":"Medical Oncology Department, Vall Hebron University Hospital, Vall Hebron Institute of Oncology (VHIO)","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"del Olmo-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia-Health Research Institute La Fe","place":["Valencia, Spain"]},{"name":"Department of Endocrinology and Nutrition, University and Polytechnic Hospital La Fe","place":["Valencia, Spain"]},{"name":"Department of Medicine, Faculty of Medicine, University of 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