{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T06:46:35Z","timestamp":1776062795110,"version":"3.50.1"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allergic rhinitis (AR) and adenoid hypertrophy (AH) are common pediatric comorbidities. Vitamin D is a known immunomodulator, but its relationship with the concurrent severity of AR and AH remains unclear. We aimed to investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels and disease severity in children with both conditions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 268 children (3\u201312\u202fyears) with co-existing AR and AH. We collected data on serum 25(OH)D, adenoidal-nasopharyngeal (A\/N) ratio, total and specific IgE, and symptom scores. Patients were stratified by 25(OH)D levels: severe deficiency (&amp;lt;10), deficiency (10\u2013&amp;lt;20), insufficiency (20\u2013&amp;lt;30), and sufficiency (\u226530\u202fng\/mL). Multiple linear\/logistic regression and restricted cubic spline (RCS) analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean 25(OH)D level was 17.7\u202f\u00b1\u202f6.8\u202fng\/mL, with a high prevalence of deficiency (70.5%\u202f&amp;lt;\u202f20\u202fng\/mL). Serum 25(OH)D levels were significantly and inversely correlated with A\/N ratio (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.34), total IgE (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.34), and symptom scores (\n                      <jats:italic>r<\/jats:italic>\n                      \u202f=\u202f\u22120.50). After full adjustment, each 10\u202fng\/mL decrease in 25(OH)D was associated with a 0.055-unit increase in A\/N ratio. Compared to sufficiency, severe deficiency conferred a 7.13-fold increased risk of severe AH (A\/N ratio \u22650.80) and a 7.83-fold increased risk of high total IgE (&amp;gt;400 kU\/L). RCS analysis revealed a significant nonlinear dose\u2013response relationship, with the strongest association observed at 25(OH)D levels below 20\u201325\u202fng\/mL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin D deficiency is highly prevalent and independently associated with increased severity of both adenoid hypertrophy and allergic inflammation in children with AR and AH. This association is most pronounced at lower vitamin D concentrations, suggesting that vitamin D status may play a role in the pathophysiology of these conditions and that correcting deficiency could be a valuable adjuvant therapeutic strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1793848","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:48:14Z","timestamp":1776059294000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The association of vitamin D deficiency with the severity of adenoid hypertrophy and allergic rhinitis in children: a retrospective observational study"],"prefix":"10.3389","volume":"13","author":[{"given":"Yating","family":"You","sequence":"first","affiliation":[{"name":"Department of Otaryngology, Head and Neck Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People\u2019s Hospital of Changde City)","place":["Changde, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otaryngology, Head and Neck Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People\u2019s Hospital of Changde City)","place":["Changde, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Otaryngology, Head and Neck Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People\u2019s Hospital of Changde City)","place":["Changde, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Otaryngology, Head and Neck Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The First People\u2019s Hospital of Changde City)","place":["Changde, Hunan, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11882-019-0843-9","article-title":"Multimorbidities of pediatric allergic rhinitis","volume":"19","author":"Mari\u00f1o-S\u00e1nchez","year":"2019","journal-title":"Curr Allergy Asthma Rep"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e18287","DOI":"10.7717\/peerj.18287","article-title":"The relationship between allergic rhinitis and attention deficit hyperactivity disorder: a systematic review and meta-analysis","volume":"12","author":"Wang","year":"2024","journal-title":"PeerJ"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.2147\/NSS.S482258","article-title":"Mutual influence between allergic rhinitis and sleep: factors, mechanisms, and interventions\u2014a 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