{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:55:33Z","timestamp":1776142533057,"version":"3.50.1"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Grip strength is a key marker for sarcopenia screening, yet the influence of iodine nutritional status on low grip strength (LGS) remains poorly understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This cross-sectional study analyzed 810 community-dwelling adults in Lanzhou, China, randomly assigned to training (\n                      <jats:italic>n<\/jats:italic>\n                      =\u202f568) and validation (\n                      <jats:italic>n<\/jats:italic>\n                      =\u202f242) cohorts. Logistic regression analyses identified factors associated with LGS. A nomogram integrating urinary iodine concentration (UIC), systolic blood pressure (SP), and routine clinical variables was constructed. Model performance was evaluated using ROC curves, Hosmer-Lemeshow test, and Brier scores. Restricted cubic spline (RCS) analysis assessed the dose\u2013response relationship between UIC and LGS, with subgroup analyses by thyroid function.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      LGS prevalence was 18.8% in the training cohort. Multivariate analysis showed female sex (OR\u202f=\u202f0.34), greater height (OR\u202f=\u202f0.94), and excessive iodine (OR\u202f=\u202f0.36) were inversely associated with LGS, whereas age (60\u201374\u202fyears: OR\u202f=\u202f2.20; \u226575\u202fyears: OR\u202f=\u202f9.73), smoking (OR\u202f=\u202f3.20), and SP (OR\u202f=\u202f1.02) correlated with higher LGS odds. The nomogram demonstrated moderate discrimination (AUC: 0.723 training, 0.662 validation) with good calibration (Brier scores: 0.134 training, 0.147 validation; H-L\n                      <jats:italic>p<\/jats:italic>\n                      &amp;gt;\u202f0.05). RCS analysis revealed a U-shaped association between UIC and LGS in unadjusted analyses, with the inverse associations most evident among euthyroid participants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The nomogram provides a practical, objective tool for early identification of individuals at high probability of LGS. Moderate-to-high UIC is associated with LGS odds, particularly in euthyroid adults. This model may guide targeted screening and interventions in community settings. In the cross-sectional design, causal inferences cannot be drawn; Further research is warranted to elucidate these complex relationships.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1793869","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T04:21:26Z","timestamp":1776140486000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship between iodine nutritional status and low handgrip strength in a Northwestern Chinese cohort: construction of a predictive nomogram model"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiao","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Endocrinology, The First Hospital of Lanzhou University","place":["Lanzhou, China"]},{"name":"School of Nursing, Lanzhou University","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[{"name":"The 940th Hospital of Chinese People\u2019s Liberation Army","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songbo","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Hospital of Lanzhou University","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghu","family":"Zhen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Hospital of Lanzhou University","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Hospital of Lanzhou University","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixia","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Hospital of Lanzhou University","place":["Lanzhou, China"]},{"name":"School of Nursing, Lanzhou University","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengxu","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Hospital of Lanzhou University","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongyan","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolic Diseases, The First Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, The First Hospital of Lanzhou University","place":["Lanzhou, China"]},{"name":"School of Nursing, Lanzhou University","place":["Lanzhou, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s41043-024-00500-y","article-title":"Hand grip strength as a proposed new vital sign of health: a narrative review of evidences","volume":"43","author":"Vaishya","year":"2024","journal-title":"J Health Popul Nutr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.arr.2017.01.004","article-title":"Handgrip strength as a means of monitoring progression of cognitive decline \u2013 a scoping review","volume":"35","author":"Fritz","year":"2017","journal-title":"Ageing Res Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"112656","DOI":"10.1016\/j.exger.2024.112656","article-title":"Association of handgrip strength 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