{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:41:57Z","timestamp":1783536117225,"version":"3.55.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>As infant formulas evolve to include bioactive components that mimic breast milk, the knowledge and perceptions of healthcare professionals (HCPs) about these innovations become critical. Pediatricians and pharmacy professionals play complementary roles in recommending and guiding infant formula use. However, disparities in understanding and communication may impact caregiver education and infant health outcomes. This study aims to assess the perceptions of Spanish pediatricians and pharmacy professionals regarding infant formulas, focusing on the recognition of ingredients, the importance attributed to them, and the understanding of their biological functions. Differences between the two professional groups were analyzed to identify gaps and educational needs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An observational, cross-sectional survey was conducted with 876 responding Spanish pediatricians (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f505) and pharmacy professionals (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f371) via anonymous online questionnaires and e-mails. The survey comprised 28 questions across three sections: sociodemographic, general perceptions of infant formulas, and functional recognition of 12 specific ingredients. Quantitative and categorical data were analyzed using appropriate statistical tests, with comparisons made between the two groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Surveyed pediatricians reported higher self-perceived knowledge than pharmacy professionals (mean score 7.9 vs. 6.7,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.0001) and showed significantly better questionnaire-based performance in identifying at least one relevant biological function of infant formula ingredients. However, surveyed pharmacy professionals placed greater emphasis on the need to educate parents (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.0001). Notable gaps emerged between self-perceived knowledge and questionnaire-based functional recognition. Among participants who reported knowing certain ingredients \u201cvery well,\u201d some were unable to correctly identify at least one relevant biological function. Both groups primarily relied on pharmaceutical industry materials for information (85.0% of pediatricians and 84.4% of pharmacy professionals).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Responding pediatricians and pharmacy professionals showed differences in their functional recognition and perception of infant formula ingredients. While the former excelled in the questionnaire-based technical recognition, the latter did so in parental education. Both profiles provide complementary strengths and show opportunities to improve knowledge about some bioactive ingredients. These results suggest potential opportunities for specific ongoing training and collaborative approaches that may help ensure consistent, evidence-based advice for caregivers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1801406","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:17:43Z","timestamp":1783531063000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Healthcare professionals\u2019 knowledge and perceptions of infant formulas composition: a comparative study of Spanish pediatricians and pharmacy professionals"],"prefix":"10.3389","volume":"13","author":[{"given":"Luis","family":"Ortiz-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences, Medicine and Health Sciences Faculty, Universidad de Extremadura","place":["Badajoz, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Santamar\u00eda-Orleans","sequence":"additional","affiliation":[{"name":"Scientific Communication, Laboratorios Ordesa SL","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d3scar","family":"Llans\u00f3-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Food and Nutrition Area, Barcelona Official College of Pharmacists","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Fern\u00e1ndez-Ribal","sequence":"additional","affiliation":[{"name":"Central Pharmacy, Gelida","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"P\u00e9rez-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Medical Department, Laboratorios Ordesa SL","place":["Barcelona, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crist\u00f3bal","family":"Coronel-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Pediatrics and Radiology, Faculty of Medicine, Amante Laff\u00f3n Health Care Centre","place":["Sevilla, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12092208","article-title":"Human breast milk: the key role in the maturation of immune, gastrointestinal and central nervous systems: a narrative review","volume":"12","author":"Dimitroglou","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"10665","DOI":"10.1021\/acs.jafc.3c07690","article-title":"Human breast milk: the role of its microbiota and metabolites in infant health","volume":"72","author":"Zhang","year":"2024","journal-title":"J Agric Food Chem"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"16","DOI":"10.36106\/ijsr\/5303875","article-title":"Breast milk vs. infant formula: a comprehensive review of nutritional content, health outcomes, and practical considerations","volume":"1","author":"Katiyar","year":"2024","journal-title":"Int J Sci Res"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"111","DOI":"10.23736\/s2724-5276.21.06223-x","article-title":"Breast milk: more than just nutrition!","volume":"73","author":"Nuzzi","year":"2021","journal-title":"Minerva Pediatr"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1542\/peds.2022-057988","article-title":"Policy statement: breastfeeding and the use of human milk","volume":"150","author":"Meek","year":"2022","journal-title":"Pediatrics"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1093\/advances\/nmz039","article-title":"Perspective: should exclusive breastfeeding still be recommended for 6 months?","volume":"10","author":"Perez-Escamilla","year":"2019","journal-title":"Adv Nutr"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1080\/20786204.2011.10874128","article-title":"Infant formulas explained","volume":"53","author":"Johnston","year":"2014","journal-title":"S Afr Fam Pract"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e104820","DOI":"10.1371\/journal.pone.0104820","article-title":"Medically complex pregnancies and early breastfeeding behaviors: a retrospective analysis","volume":"9","author":"Kozhimannil","year":"2014","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3390\/nu8050279","article-title":"Review of 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Beneficios sanitarios y funcionales","volume":"34","author":"De Almagro Garcia","year":"2017","journal-title":"Nutr Hosp"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2147\/nds.S192099","article-title":"Insights into novel infant milk formula bioactives","volume":"12","author":"Skolnick","year":"2020","journal-title":"Nutr Diet Suppl"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s12937-016-0147-z","article-title":"Effects of milk containing only A2 beta casein versus milk containing both A1 and A2 beta casein proteins on gastrointestinal physiology, symptoms of discomfort, and cognitive behavior of people with self-reported intolerance to traditional cows' milk","volume":"15","author":"Jianqin","year":"2016","journal-title":"Nutr J"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1159\/000534004","article-title":"Role of pediatricians in promoting and supporting breastfeeding: a position paper of the international pediatric association strategic advisory group on infant, child, and adolescent nutrition","volume":"79","author":"Fewtrell","year":"2023","journal-title":"Ann Nutr Metab"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e28","DOI":"10.1331\/JAPhA.2011.09125","article-title":"Pharmacists\u2019 guide to infant formulas for term infants","volume":"51","author":"Smith","year":"2003","journal-title":"J Am Pharm Assoc"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1017\/S1368980018003178","article-title":"Informed choice or guessing game? Understanding caregivers' perceptions and use of infant formula labelling","volume":"22","author":"Malek","year":"2019","journal-title":"Public Health Nutr"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1111\/phn.13355","article-title":"Health professionals' counselling on the use of infant formula: a scoping review","volume":"41","author":"Hvatum","year":"2024","journal-title":"Public Health Nurs"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1177\/1715163517745517","article-title":"Pharmacists as accessible primary health care providers: review of the evidence","volume":"151","author":"Tsuyuki","year":"2018","journal-title":"Can Pharm J (Ott)"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"e140111","DOI":"10.7363\/140111","article-title":"Pediatricians\u2019 knowledge and perception of the care of the infant with jaundice","volume":"14","author":"Dotan","year":"2025","journal-title":"J Pediatr Neonatal Individ Med"},{"key":"ref28","first-page":"1971","article-title":"Measuring perceived, wished and actual knowledge of healthcare providers about pediatric palliative care: development and validation of an online questionnaire in Italy","author":"Zanello","year":"2023"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"868","DOI":"10.3390\/ijms26125868","article-title":"Osteopontin: its properties, recent studies, and potential applications","volume":"26","author":"Karasalih","year":"2025","journal-title":"Int J Mol Sci"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1002\/jpn3.12192","article-title":"Infant formula ingredients: updates for clinicians","volume":"78","author":"Rodrigo","year":"2024","journal-title":"J Pediatr Gastroenterol Nutr"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1801406\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:17:44Z","timestamp":1783531064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1801406\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":30,"alternative-id":["10.3389\/fnut.2026.1801406"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1801406","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"article-number":"1801406"}}