{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T05:13:52Z","timestamp":1783660432323,"version":"3.55.0"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background\/objectives<\/jats:title>\n                    <jats:p>The present study investigated the effect of selenium-enriched eggs (SE egg) vs. zeaxanthin-enriched eggs (ZE egg) on glycemic and lipid metabolism in patients with diabetes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty-eight patients with type 2 diabetes were recruited and randomly divided into group SE egg (27 subjects) and ZE egg (31 subjects). The two groups of participants consumed either SE egg or ZE egg twice a day for a total of 12\u202fweeks of intervention. Fasting blood samples were collected before and after the intervention to detect changes in blood glucose and lipid levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After the intervention, the fasting blood glucose, homeostatic model assessment of insulin resistance, and triglyceride-glucose index of both SE and ZE groups of subjects significantly decreased (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05). Among subjects with a baseline glycosylated hemoglobin A1c (HbA1c)\u202f&amp;lt;\u202f8.9%, eggs from both groups showed an enhanced improvement in glucose and lipid metabolism. The ZE egg group showed a significant decrease in triglycerides (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0007) and an increase in homeostatic model assessment of\n                      <jats:italic>\u03b2<\/jats:italic>\n                      -cell function (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.06). There was no significant difference in HbA1c between the two groups after the intervention.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that SE egg and ZE eggs have comparable effects on improving glucose metabolism profiles in diabetic patients, with an improved efficacy observed in subjects with lower baseline HbA1c levels. Furthermore, ZE eggs suggest potential benefits in lowering TG levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.chictr.org.cn\/index.html<\/jats:ext-link>\n                      , Identifer, ChiCTR2300077522.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1803814","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:25:38Z","timestamp":1783657538000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Glycemic and lipid responses to selenium-enriched vs. zeaxanthin-enriched eggs in patients with type 2 diabetes: a 12-week randomized controlled trial"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaokang","family":"Niu","sequence":"first","affiliation":[{"name":"Research Center for Probiotics, Department of Nutrition and Health, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nutrition, The First Medical Center of Chinese PLA General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Nutrition, The First Medical Center of Chinese PLA General Hospital","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinhua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Research Center for Probiotics, Department of Nutrition and Health, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Fang","sequence":"additional","affiliation":[{"name":"Research Center for Probiotics, Department of Nutrition and Health, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghao","family":"Hu","sequence":"additional","affiliation":[{"name":"Henan Layer Breeding Engineering Technology Research Center","place":["Jiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Henan Layer Breeding Engineering Technology Research Center","place":["Jiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Probiotics, Department of Nutrition and Health, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Sang","sequence":"additional","affiliation":[{"name":"Research Center for Probiotics, Department of Nutrition and Health, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Research Center for Probiotics, Department of Nutrition and Health, China Agricultural University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Guo","sequence":"additional","affiliation":[{"name":"Research Center for Probiotics, Department of Nutrition and Health, China Agricultural University","place":["Beijing, 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