{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:53:42Z","timestamp":1788188022946,"version":"build-2803163510"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T00:00:00Z","timestamp":1774396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>\n                    Currently, \u201cmedicinal food\u201d is a trending topic of discussion given the various bioactive compounds found within edible mushrooms. However, research on the collection and biological potency of saponins extracted from hazel mushroom, a species of\n                    <jats:italic>Armillaria<\/jats:italic>\n                    , is lacking. We aimed to conduct additional studies with respect to our previous endeavor, which was an effort to determine possible methods that can be used to alleviate ultrasonic-assisted extraction conditions of compounds and determine possible anticancer effects. Response surface methodology can be used to identify good extraction parameters, such as the ethanol concentration 73.28%, solid\/liquid ratio 1:24.88\u202fg\/mL, and time 12.5\u202fmin, to obtain a maximum value of 21.4%. After extraction, we analyzed specific patterns of some saponins via ultrahigh performance liquid chromatography\/ quadrupole time-of-flight mass spectrometry, which meant that these compound act on tumor cells. This study was conducted to determine the effect of such compounds on cancer.\n                  <\/jats:p>","DOI":"10.3389\/fnut.2026.1809982","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:56:52Z","timestamp":1774454212000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Research on the extraction of total saponins from hazel mushrooms via an ultrasound-assisted extraction method and their antitumor activity"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuan","family":"Fang","sequence":"first","affiliation":[{"name":"School of Laboratory Medicine (Pharmaceutical Sciences), Jilin Medical University","place":["Jilin City, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilizhati","family":"Yimamu","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine (Pharmaceutical Sciences), Jilin Medical University","place":["Jilin City, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Cui","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine (Pharmaceutical Sciences), Jilin Medical University","place":["Jilin City, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjun","family":"Kan","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine (Pharmaceutical Sciences), Jilin Medical University","place":["Jilin City, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine (Pharmaceutical Sciences), Jilin Medical University","place":["Jilin City, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Laboratory Medicine (Pharmaceutical Sciences), Jilin Medical University","place":["Jilin City, Jilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"11239","DOI":"10.1080\/21655979.2021.2001183","article-title":"A review of the therapeutic and biological effects of edible and wild mushrooms","volume":"12","author":"Anusiya","year":"2021","journal-title":"Bioengineered"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3185","DOI":"10.3390\/agronomy12123185","article-title":"Novel perspective of medicinal mushroom cultivations: a review case for \u2018magic\u2019 mushrooms","volume":"12","author":"Sommano","year":"2022","journal-title":"Agronomy"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1615\/intjmedmushrooms.2022043738","article-title":"Research trends of study of edible mushrooms: nutritional properties and health 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