{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:04:18Z","timestamp":1790183058940,"version":"4.1.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004403","name":"Th\u00fcringer Aufbaubank","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004403","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Overweight is a major public health concern. Beyond traditional dietary therapy, mobile health (mHealth) applications have gained interest for their potential to support weight loss. However, evidence on their efficacy remains limited. This study evaluated the effectiveness of an app-based dietary concept for weight reduction and improvement of further cardiovascular risk factors. Methods: The PreVa study is a single-center, randomized, four-arm parallel intervention study comparing an app-based nutrition program with standard therapy involving personal counseling. Eighty adults with a body mass index between 25 and &amp;lt; 35 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      were randomly assigned to one of four groups (1) app-based, (2) individual coaching, (3) general dietary recommendations and (4) control. All intervention groups received individualized, nutrient-optimized menu plans with integrated flaxseed oil supplementation, either via app or in printed form, combined with varying levels of counseling. Energy intake was gradually reduced every 4 weeks, with maintenance phases at the beginning and end of the 16-week intervention. Anthropometric and biochemical parameters were measured at four-week intervals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After 12 weeks of energy reduction, weight loss was significantly greater in the intervention groups (\u22126.5 %, \u22127.3 %, \u22126.0 %) than in the control group (\u22122.1 %;\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001) and remained stable during the maintenance phase (16 weeks; all\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.01). A clinically relevant (&amp;gt; 5 %) weight loss was achieved by 66.7 %, 78.9 %, and 53.3 % of participants for all interventions, respectively. Blood pressure was reduced in all intervention groups (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05), while the values differ not significantly from control group. Total and LDL cholesterol decreased in group 2 and 3 (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.05), the changes differ significantly from the control group. Group 1 exhibited a significant decrease in fasting glucose and HOMA-IR compared to the other groups. \u03b1-Linolenic concentrations increased markedly (+ 52.7\u201379.4 %;\n                      <jats:italic>p<\/jats:italic>\n                      \u2264 0.01), whereas eicosapentaenoic acid and docosahexaenoic acid remained unchanged. No relevant changes were observed in micronutrient status.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The intervention groups achieved clinically meaningful weight loss and an improvement in blood lipid levels. The greatest effect is likely attributable to the individualized, nutrient-optimized menu plans rather than the type of counseling or delivery mode.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/clinicaltrials.gov\/<\/jats:ext-link>\n                      , identifier NCT04717076\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1815820","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:15:13Z","timestamp":1790180113000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A randomized parallel-designed study evaluating the effect of an app-based nutritional concept for weight reduction and further cardiovascular risk factors: Insights from the PreVA study"],"prefix":"10.3389","volume":"13","author":[{"given":"Lea","family":"Klein","sequence":"first","affiliation":[{"name":"Junior Research Group Nutritional Concepts, Institute of Nutritional Sciences, Friedrich Schiller University Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Biernath","sequence":"additional","affiliation":[{"name":"Junior Research Group Nutritional Concepts, Institute of Nutritional Sciences, Friedrich Schiller University Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Kipp","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Weimar, Sophien- und Hufeland-Klinikum","place":["Weimar, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kiehntopf","sequence":"additional","affiliation":[{"name":"Institute of Clinical Chemistry and Laboratory Diagnostics, University Hospital","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susann","family":"Scherag","sequence":"additional","affiliation":[{"name":"Preventicus GmbH","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Meier","sequence":"additional","affiliation":[{"name":"Preventicus GmbH","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"Preventicus GmbH","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Lorkowski","sequence":"additional","affiliation":[{"name":"Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig","place":["Jena, Germany"]},{"name":"Institute of Nutritional Sciences, Friedrich Schiller University Jena","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Dawczynski","sequence":"additional","affiliation":[{"name":"Junior Research Group Nutritional Concepts, Institute of Nutritional Sciences, Friedrich Schiller University Jena","place":["Jena, Germany"]},{"name":"Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig","place":["Jena, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","unstructured":"Obesity and Overweight.\n          \n          2024","DOI":"10.1155\/2024\/9587300"},{"key":"B2","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/S0140-6736(25)00355-1","article-title":"Global, regional, and national prevalence of adult overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021.","volume":"405","year":"2025","journal-title":"Lancet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/S0140-6736(23)02750-2","article-title":"Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults.","volume":"403","year":"2024","journal-title":"Lancet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1186\/1471-2458-9-88","article-title":"The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis.","volume":"9","author":"Guh","year":"2009","journal-title":"BMC Public Health"},{"key":"B5","volume-title":"The Heavy Burden of Obesity: The Economics of Prevention.","year":"2019"},{"key":"B6","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: global epidemiology and pathogenesis.","volume":"15","author":"Bl\u00fcher","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1093\/eurjpc\/zwae136","article-title":"Cardiovascular mortality attributable to dietary risk factors in 54 countries in the WHO European Region from 1990 to 2019: an updated systematic analysis of the Global Burden of Disease Study.","volume":"32","author":"P\u00f6rschmann","year":"2025","journal-title":"Eur J Prev Cardiol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s40608-014-0022-4","article-title":"Effectiveness of mobile electronic devices in weight loss among overweight and obese populations: a systematic review and meta-analysis.","volume":"1","author":"Khokhar","year":"2014","journal-title":"BMC Obes"},{"key":"B9","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1111\/obr.12492","article-title":"A meta-analysis of overall effects of weight loss interventions delivered via mobile phones and effect size differences according to delivery mode, personal contact, and intervention intensity and duration.","volume":"18","author":"Schippers","year":"2017","journal-title":"Obes Rev"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e35479","DOI":"10.2196\/35479","article-title":"The effectiveness of combining nonmobile interventions with the use of smartphone apps with various features for weight loss: systematic review and meta-analysis.","volume":"10","author":"Antoun","year":"2022","journal-title":"JMIR Mhealth Uhealth"},{"key":"B11","doi-asserted-by":"publisher","first-page":"e13483","DOI":"10.1111\/obr.13483","article-title":"The effectiveness of technology-based interventions for weight loss maintenance: a systematic review of randomized controlled trials with meta-analysis.","volume":"23","author":"Mamalaki","year":"2022","journal-title":"Obes Rev"},{"key":"B12","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1136\/bmjinnov-2015-000096","article-title":"Evolution and current status of mhealth research: a systematic review.","volume":"2","author":"Ali","year":"2016","journal-title":"BMJ Innovat"},{"key":"B13","doi-asserted-by":"publisher","first-page":"608854","DOI":"10.3389\/fnut.2020.608854","article-title":"A study protocol for a parallel-designed trial evaluating the impact of plant-based diets in comparison to animal-based diets on health status and prevention of non-communicable diseases-the nutritional evaluation (NuEva) study.","volume":"7","author":"Dawczynski","year":"2021","journal-title":"Front Nutr"},{"key":"B14","doi-asserted-by":"publisher","first-page":"100761","DOI":"10.1016\/j.conctc.2021.100761","article-title":"A study protocol of a randomized trial evaluating the effect of using defined menu plans within an intensive personal nutritional counseling program on cardiovascular risk factors: the MoKaRi (modulation of cardiovascular risk factors) trial.","volume":"22","author":"Dawczynski","year":"2021","journal-title":"Contemp Clin Trials Commun"},{"key":"B15","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/s0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipides from animal tissues.","volume":"226","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"B16","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1139\/o59-099","article-title":"A rapid method of total lipid extraction and purification.","volume":"37","author":"Bligh","year":"1959","journal-title":"Can J Biochem Physiol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1258-65","DOI":"10.1093\/gerona\/glv194","article-title":"Six-month calorie restriction in overweight individuals elicits transcriptomic response in subcutaneous adipose tissue that is distinct from effects of energy deficit.","volume":"71","author":"Lam","year":"2016","journal-title":"J Gerontol A Biol Sci Med Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.7326\/M13-3005","article-title":"Effectiveness of a smartphone application for weight loss compared with usual care in overweight primary care patients: a randomized, controlled trial.","volume":"161","author":"Laing","year":"2014","journal-title":"Ann Intern Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1089\/met.2017.0062","article-title":"Effectiveness of a smartphone application for the management of metabolic syndrome components focusing on weight loss: a preliminary study.","volume":"15","author":"Toro-Ramos","year":"2017","journal-title":"Metab Syndr Relat Disord"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1002\/oby.23744","article-title":"A randomized-controlled trial to evaluate the app-based multimodal weight loss program zanadio for patients with obesity.","volume":"31","author":"Roth","year":"2023","journal-title":"Obesity"},{"key":"B21","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/s41366-023-01415-0","article-title":"Efficacy of an app-based multimodal lifestyle intervention on body weight in persons with obesity: results from a randomized controlled trial.","volume":"48","author":"Gemesi","year":"2024","journal-title":"Int J Obes (Lond)"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e14","DOI":"10.2196\/mhealth.7713","article-title":"Face-to-face versus mobile versus blended weight loss program: randomized clinical trial.","volume":"6","author":"Hurkmans","year":"2018","journal-title":"JMIR Mhealth Uhealth"},{"key":"B23","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.ypmed.2010.04.018","article-title":"Internet delivered behavioral obesity treatment.","volume":"51","author":"Harvey-Berino","year":"2010","journal-title":"Prev Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/oby.22410","article-title":"Comparison of smartphone-based behavioral obesity treatment with gold standard group treatment and control: a randomized trial.","volume":"27","author":"Thomas","year":"2019","journal-title":"Obesity (Silver Spring)"},{"key":"B25","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.nut.2014.09.002","article-title":"Comparative effectiveness of plant-based diets for weight loss: a randomized controlled trial of five different diets.","volume":"31","author":"Turner-McGrievy","year":"2015","journal-title":"Nutrition"},{"key":"B26","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s11606-015-3390-7","article-title":"Vegetarian diets and weight reduction: a meta-analysis of randomized controlled trials.","volume":"31","author":"Huang","year":"2016","journal-title":"J Gen Intern Med"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e256","DOI":"10.1038\/nutd.2017.3","article-title":"The BROAD study: a randomised controlled trial using a whole food plant-based diet in the community for obesity, ischaemic heart disease or diabetes.","volume":"7","author":"Wright","year":"2017","journal-title":"Nutr Diabetes"},{"key":"B28","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1111\/j.1467-3010.2007.00616.x","article-title":"Carbohydrates and dietary fibre.","volume":"32","author":"Lunn","year":"2007","journal-title":"Nutr Bull"},{"key":"B29","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s13679-015-0156-9","article-title":"Adaptive thermogenesis in resistance to obesity therapies: issues in quantifying thrifty energy expenditure phenotypes in humans.","volume":"4","author":"Dulloo","year":"2015","journal-title":"Curr Obes Rep"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1718.e","DOI":"10.1053\/j.gastro.2017.01.052","article-title":"Obesity energetics: body weight regulation and the effects of diet composition.","volume":"152","author":"Hall","year":"2017","journal-title":"Gastroenterology"},{"key":"B31","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/ejcn.2009.68","article-title":"Body mass index, waist circumference and waist:hip ratio as predictors of cardiovascular risk\u2013a review of the literature.","volume":"64","author":"Huxley","year":"2010","journal-title":"Eur J Clin Nutr"},{"key":"B32","doi-asserted-by":"publisher","first-page":"463","DOI":"10.5114\/aoms.2015.52350","article-title":"Central obesity, type 2 diabetes and insulin: exploring a pathway full of thorns.","volume":"11","author":"Papaetis","year":"2015","journal-title":"Arch Med Sci"},{"key":"B33","volume-title":"Waist Circumference and Waist-Hip Ratio: Report of a WHO Expert Consultation.","year":"2008"},{"key":"B34","doi-asserted-by":"publisher","first-page":"851","DOI":"10.5114\/aoms.2016.58928","article-title":"Obesity and inflammation: the linking mechanism and the complications.","volume":"13","author":"Ellulu","year":"2017","journal-title":"Arch Med Sci"},{"key":"B35","doi-asserted-by":"publisher","first-page":"dgaa673","DOI":"10.1210\/clinem\/dgaa673","article-title":"Weight loss and serum lipids in overweight and obese adults: a systematic review and meta-analysis.","volume":"105","author":"Hasan","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e312","DOI":"10.3399\/bjgp20X714113","article-title":"Effect of weight loss on cardiometabolic risk: observational analysis of two randomised controlled trials of community weight-loss programmes.","volume":"71","author":"Morris","year":"2021","journal-title":"Br J Gen Pract"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1056\/NEJM199704173361601","article-title":"A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group.","volume":"336","author":"Appel","year":"1997","journal-title":"N Engl J Med"},{"key":"B38","doi-asserted-by":"publisher","first-page":"104500","DOI":"10.1016\/j.jff.2021.104500","article-title":"Effects of dietary fiber on glycemic control and insulin sensitivity in patients with type 2 diabetes: a systematic review and meta-analysis.","volume":"82","author":"Mao","year":"2021","journal-title":"J Funct Foods"},{"key":"B39","doi-asserted-by":"publisher","first-page":"320S","DOI":"10.1080\/07315724.2000.10718967","article-title":"Mechanisms of the effects of grains on insulin and glucose responses.","volume":"19","author":"Hallfrisch","year":"2000","journal-title":"J Am Coll Nutr"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.2337\/dc16-1728","article-title":"Physical activity\/exercise and diabetes: a position statement of the American Diabetes Association.","volume":"39","author":"Colberg","year":"2016","journal-title":"Diabetes Care"},{"key":"B41","doi-asserted-by":"publisher","first-page":"e722","DOI":"10.1161\/CIR.0000000000001040","article-title":"Comprehensive management of cardiovascular risk factors for adults with type 2 diabetes: a scientific statement from the American Heart Association.","volume":"145","author":"Joseph","year":"2022","journal-title":"Circulation"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1093\/jn\/135.9.2075","article-title":"Mechanisms by which dietary fatty acids modulate plasma lipids.","volume":"135","author":"Fernandez","year":"2005","journal-title":"J Nutr"},{"key":"B43","article-title":"The effect of diet on cardiovascular disease and lipid and lipoprotein levels.","volume-title":"Endotext.","author":"Feingold","year":"2024"},{"key":"B44","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1089\/154099903321576493","article-title":"Dietary fat and cardiovascular disease risk: quantity or quality?","volume":"12","author":"Lichtenstein","year":"2003","journal-title":"J Womens Health (Larchmt)"},{"key":"B45","doi-asserted-by":"publisher","first-page":"145","DOI":"10.14740\/jocmr2030w","article-title":"Effects of dietary fat intake on HDL metabolism.","volume":"7","author":"Yanai","year":"2015","journal-title":"J Clin Med Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1136\/heartjnl-2011-301405","article-title":"Changes in HDL cholesterol and cardiovascular outcomes after lipid modification therapy.","volume":"98","author":"Ray","year":"2012","journal-title":"Heart"},{"key":"B47","doi-asserted-by":"publisher","first-page":"b92","DOI":"10.1136\/bmj.b92","article-title":"Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis.","volume":"338","author":"Briel","year":"2009","journal-title":"BMJ"},{"key":"B48","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1093\/ajcn\/69.1.30","article-title":"Cholesterol-lowering effects of dietary fiber: a meta-analysis.","volume":"69","author":"Brown","year":"1999","journal-title":"Am J Clin Nutr"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.3390\/nu12092671","article-title":"The role of specific components of a plant-based diet in management of dyslipidemia and the impact on cardiovascular risk.","volume":"12","author":"Trautwein","year":"2020","journal-title":"Nutrients"},{"key":"B50","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1016\/S2213-8587(20)30148-0","article-title":"Intake and metabolism of omega-3 and omega-6 polyunsaturated fatty acids: nutritional implications for cardiometabolic diseases.","volume":"8","author":"Schulze","year":"2020","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.ypmed.2004.02.030","article-title":"The Omega-3 Index: a new risk factor for death from coronary heart disease?","volume":"39","author":"Harris","year":"2004","journal-title":"Prev Med"},{"key":"B52","doi-asserted-by":"publisher","first-page":"4461","DOI":"10.3390\/nu15204461","article-title":"Evaluation of influencing factors on metabolism of land-based n-3 poly unsaturated fatty acids-the KoALA study.","volume":"15","author":"Drobner","year":"2023","journal-title":"Nutrients"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1587","DOI":"10.1039\/c7fo01809f","article-title":"Effects of a 12-week high-\u03b1-linolenic acid intervention on EPA and DHA concentrations in red blood cells and plasma oxylipin pattern in subjects with a low EPA and DHA status.","volume":"9","author":"Greupner","year":"2018","journal-title":"Food Funct"},{"key":"B54","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1079\/bjn2003901","article-title":"Effect of altered dietaryn-3 fatty acid intake upon plasma lipid fatty acid composition, conversion of [13C]\u03b1-linolenic acid to longer-chain fatty acids and partitioning towards \u03b2-oxidation in older men.","volume":"90","author":"Burdge","year":"2003","journal-title":"Br J Nutr"},{"key":"B55","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.plefa.2015.01.001","article-title":"The effect of modifying dietary LA and ALA intakes on omega-3 long chain polyunsaturated fatty acid (n-3 LCPUFA) status in human adults: a systematic review and commentary.","volume":"95","author":"Wood","year":"2015","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"B56","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.nut.2017.11.002","article-title":"Effects of a hypoenergetic diet rich in \u03b1-linolenic acid on fatty acid composition of serum phospholipids in overweight and obese patients with metabolic syndrome.","volume":"49","author":"Egert","year":"2018","journal-title":"Nutrition"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1727308","DOI":"10.3389\/fnut.2025.1727308","article-title":"Impact of \u03b1-linolenic acid supplementation on long-chain n-3 fatty acid profiles in Western, flexitarian, vegetarian, and vegan diets.","volume":"12","author":"Klein","year":"2025","journal-title":"Front Nutr"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1194\/jlr.M300509-JLR200","article-title":"Decreased membrane fluidity and altered susceptibility to peroxidation and lipid composition in overweight and obese female erythrocytes.","volume":"45","author":"Cazzola","year":"2004","journal-title":"J Lipid Res"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1017\/S0007114509382173","article-title":"Plasma n-3 polyunsaturated fatty acids are negatively associated with obesity.","volume":"102","author":"Micallef","year":"2009","journal-title":"Br J Nutr"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e532","DOI":"10.3109\/17477166.2010.549489","article-title":"Omega-3 index, obesity and insulin resistance in children.","volume":"6","author":"Burrows","year":"2011","journal-title":"Int J Pediatr Obes"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.3390\/nu12051480","article-title":"Association between obesity and omega-3 status in healthy young women.","volume":"12","author":"Young","year":"2020","journal-title":"Nutrients"},{"key":"B62","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1111\/obr.12280","article-title":"Long-chain polyunsaturated fatty acid status in obesity: a systematic review and meta-analysis.","volume":"16","author":"Fekete","year":"2015","journal-title":"Obes Rev"},{"key":"B63","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.numecd.2005.06.001","article-title":"Fatty acid composition and estimated desaturase activities are associated with obesity and lifestyle variables in men and women.","volume":"16","author":"Warensj\u00f6","year":"2006","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"B64","doi-asserted-by":"publisher","first-page":"S91","DOI":"10.1017\/s000711450000101x","article-title":"Dietary fat and insulin action in humans.","volume":"83","author":"Vessby","year":"2000","journal-title":"Br J Nutr"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1042\/bst0301076","article-title":"Gene regulation of mammalian desaturases.","volume":"30","author":"Nakamura","year":"2002","journal-title":"Biochem Soc Trans"},{"key":"B66","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.plefa.2006.05.013","article-title":"Metabolism of alpha-linolenic acid in humans.","volume":"75","author":"Burdge","year":"2006","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"B67","unstructured":"Society\n              GO.\n            \n          \n          S3-Leitlinie Adipositas - Pr\u00e4vention und Therapie.\n          \n          2024"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.3945\/ajcn.114.099150","article-title":"Amino acids, lipid metabolites, and ferritin as potential mediators linking red meat consumption to type 2 diabetes.","volume":"101","author":"Wittenbecher","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"B69","doi-asserted-by":"publisher","first-page":"93","DOI":"10.3389\/fnut.2019.00093","article-title":"Vitamin B12 intake from animal foods, biomarkers, and health aspects.","volume":"6","author":"Obeid","year":"2019","journal-title":"Front Nutr"},{"key":"B70","doi-asserted-by":"publisher","first-page":"15307","DOI":"10.1038\/s41598-018-33534-4","article-title":"The relationship between plasma ferritin levels and body mass index among adolescents.","volume":"8","author":"Shattnawi","year":"2018","journal-title":"Sci Rep"},{"key":"B71","doi-asserted-by":"publisher","first-page":"249","DOI":"10.5830\/CVJA-2011-015","article-title":"The relationship between indices of iron status and selected anthropometric cardiovascular disease risk markers in an African population: the THUSA study.","volume":"22","author":"Aderibigbe","year":"2011","journal-title":"Cardiovasc J Afr."},{"key":"B72","doi-asserted-by":"publisher","first-page":"4484","DOI":"10.1097\/MS9.0000000000003428","article-title":"The impact of weight loss interventions on thyroid function: a systematic review and meta-analysis.","volume":"87","author":"Nayak","year":"2025","journal-title":"Ann Med Surg (Lond)"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1815820\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:15:16Z","timestamp":1790180116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1815820\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":72,"alternative-id":["10.3389\/fnut.2026.1815820"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1815820","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"article-number":"1815820"}}