{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:37:31Z","timestamp":1782970651824,"version":"3.54.5"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IIT Clinical Research Fund of The Second Affiliated Hospital of Xi\u2019an Jiaotong University","award":["M074"],"award-info":[{"award-number":["M074"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"\n Objective<\/jats:title>\n The prognostic value of low muscle mass and visceral adiposity (LMM-VA) in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt (TIPS) has not yet been investigated. We aimed to define LMM-VA using computed tomography-based skeletal muscle index (SMI) and visceral-to-subcutaneous adipose tissue ratio (VSR), and to examine its association with post-TIPS outcomes.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective cohort study included adult patients with cirrhosis undergoing TIPS. LMM-VA was defined as the coexistence of low muscle mass (SMI\u202f&lt;\u202f44.7\u202fcm\n 2<\/jats:sup>\n \/m\n 2<\/jats:sup>\n in males and &lt; 32.5\u202fcm\n 2<\/jats:sup>\n \/m\n 2<\/jats:sup>\n in females) and visceral adiposity (VSR\u202f\u2265\u202f1.21 in males and \u2265 0.48 in females). Associations between LMM-VA and post-TIPS outcomes were evaluated using cumulative incidence curves and univariable and multivariable regression models.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 228 patients with cirrhosis were included in the study, 54 (23.7%) of whom had LMM-VA. During a median follow-up of 29.2\u202fmonths, patients with LMM-VA showed a significantly higher cumulative incidence of both all-cause mortality (\n p<\/jats:italic>\n \u202f&lt;\u202f0.001) and liver-related mortality (\n p<\/jats:italic>\n \u202f&lt;\u202f0.001). LMM-VA was significantly associated with post-TIPS all-cause mortality in both the univariable (hazard ratio [HR]: 3.62, 95% confidence interval [CI]: 1.65\u20137.91) and multivariable Cox regression analyses (HR: 3.21, 95% CI: 1.32\u20137.80). Subgroup, sensitivity, and stratified analyses further confirmed the robustness of this association. Additionally, LMM-VA demonstrated an independent prognostic value for liver-related mortality but not for either new-onset or further decompensation. The significant association between LMM-VA and all-cause mortality was lost when LMM-VA was defined by either a visceral adipose tissue area of \u2265 100\u202fcm\n 2<\/jats:sup>\n or body mass index of \u2265 25.0\u202fkg\/m\n 2<\/jats:sup>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n LMM-VA is significantly associated with increased post-TIPS mortality in patients with cirrhosis and may serve as a promising prognostic marker that requires further validation.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fnut.2026.1817771","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:24:57Z","timestamp":1782966297000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic impact of low muscle mass and visceral adiposity in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt: a retrospective cohort study"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhang","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"Clinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Xijing Hospital of Digestive Diseases, Fourth Military Medical University","place":["Xi'an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"Clinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"Clinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"Clinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"Clinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyue","family":"Tuo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"Clinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meijuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, Shaanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"Clinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shejiao","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"Clinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"Clinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxing","family":"Tantai","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University","place":["Xi\u2019an, China"]},{"name":"Clinical Research Center for Gastrointestinal Diseases of Shaanxi Province, The Second Affiliated Hospital of Xi'an Jiaotong 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