{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T15:07:49Z","timestamp":1779289669599,"version":"3.51.4"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:00:00Z","timestamp":1779235200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>\n                    Wheat-based pasta, a staple food for many populations, represents a potential vehicle for bioactive compounds and micronutrients. This study aimed to enhance the nutritional and functional properties of fresh pasta by incorporating 12.5% orange or purple carrot flour. Pasta containing orange (O) or purple (P) carrot flour and a conventional pasta (control) were characterized in terms of nutritional composition, sensory profile and microbiological stability. The antioxidant and anti-inflammatory properties were investigated using\n                    <jats:italic>in vitro<\/jats:italic>\n                    assays with the human Caco-2 cell line. Both enriched pastas could be labelled as \u201crich in fibre,\u201d while only pasta O qualified as a \u201csource of vitamin A.\u201d The enriched samples exhibited increased antioxidant capacity, attributable to the high content of phenolic compounds and anthocyanins in P and \u03b2-carotene in O. Exposure of Caco-2 cell to pasta digests in the presence of a synthetic pro-oxidant did not result in significant differences in reactive oxygen species levels. However, P digest, after colonic fermentation, induced a decrease of NF-\u03baB phosphorylation, suggesting an inhibitory effect on the pro-inflammatory response. Both enriched pastas led to a decrease in vimentin expression, while an increase in E-cadherin expression was exclusively observed in cells treated with the P digest, as confirmed by immunofluorescence analysis. Microbiologically, all pasta samples were stable for 110\u202fdays. Overall, using carrot flour, particularly from purple cultivars, has proved to be an effective strategy of improving the nutritional and functional properties of fresh pasta while maintaining good sensory profile.\n                  <\/jats:p>","DOI":"10.3389\/fnut.2026.1818508","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T14:10:40Z","timestamp":1779286240000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Carrot flour-enriched pasta with in vitro antioxidant activity and capacity of modulating inflammatory pathways in human colon cell model"],"prefix":"10.3389","volume":"13","author":[{"given":"Alessia","family":"Lisi","sequence":"first","affiliation":[{"name":"Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro","place":["Bari, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giusy Rita","family":"Caponio","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Biotechnology and Environment, University of Bari Aldo Moro","place":["Bari, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Calasso","sequence":"additional","affiliation":[{"name":"Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro","place":["Bari, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia","family":"Tamma","sequence":"additional","affiliation":[{"name":"Department of Bioscience, Biotechnology and Environment, University of Bari Aldo Moro","place":["Bari, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilenia","family":"Ceglie","sequence":"additional","affiliation":[{"name":"Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro","place":["Bari, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Mancini","sequence":"additional","affiliation":[{"name":"Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro","place":["Bari, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziana","family":"Difonzo","sequence":"additional","affiliation":[{"name":"Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro","place":["Bari, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Minervini","sequence":"additional","affiliation":[{"name":"Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro","place":["Bari, Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"De Angelis","sequence":"additional","affiliation":[{"name":"Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro","place":["Bari, 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