{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:22:33Z","timestamp":1787026953114,"version":"build-2736575974"},"reference-count":211,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371386"],"award-info":[{"award-number":["31371386"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30871239"],"award-info":[{"award-number":["30871239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Obesity has become a global public health crisis. It is characterized by pathological proliferation of adipose tissue resulting from an energy metabolism imbalance. Adipocyte differentiation is the core process driving this proliferation and is tightly regulated by a complex molecular network. Peroxisome proliferator-activated receptor gamma (PPAR-\u03b3) is the primary regulator of adipocyte differentiation. It also plays a key regulatory role in lipid and glucose metabolism as well as inflammatory responses. Its dysregulation is closely associated with the onset and progression of obesity. This review goes beyond a descriptive summary of PPAR-\u03b3\u2019s role in adipogenesis and instead focuses on the context-dependent roles of this factor in the pathophysiology of obesity. This article maps the upstream and downstream molecular networks regulating PPAR-\u03b3 activity. It also analyzes the dual and even opposing functions that PPAR-\u03b3 exhibits under different physiological and pathological conditions. By integrating cutting-edge research advances, this review further elucidates the tissue-specific mechanisms of PPAR-\u03b3 and evaluates the therapeutic potential of targeting this pathway in obesity interventions. This review aims to provide a theoretical framework for understanding the mechanisms by which PPAR-\u03b3 dysfunction contributes to the development of obesity. It offers a reference for the development of precision treatment strategies for obesity and related metabolic diseases.<\/jats:p>","DOI":"10.3389\/fnut.2026.1820776","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:17:52Z","timestamp":1779949072000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The context-dependent roles of PPAR-\u03b3 in adipocyte differentiation and obesity: a master regulator with dual functions"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaoli","family":"Hou","sequence":"first","affiliation":[{"name":"Center for Molecular Medicine, Zhengzhou Health College, Zhengzhou","place":["Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqiu","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, Zhengzhou Health College, Zhengzhou","place":["Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixia","family":"Dong","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, Zhengzhou Health College, Zhengzhou","place":["Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, Zhengzhou Health College, Zhengzhou","place":["Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoping","family":"Ji","sequence":"additional","affiliation":[{"name":"Center for Molecular Medicine, Zhengzhou Health College, Zhengzhou","place":["Henan, China"]},{"name":"Department of Gastroenterology, Huaihe Hospital of Henan University, Kaifeng","place":["Henan, China"]},{"name":"Department of Biochemistry and Molecular Biology, Medical School, Henan University, Kaifeng","place":["Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"5883","DOI":"10.1038\/s41467-025-60754-w","article-title":"Commitment of adipose-resident c-kit+ progenitors to brown adipocytes contributes to adipose tissue homeostasis and remodeling.","volume":"16","author":"Chen","year":"2025","journal-title":"Nat Commun"},{"key":"B2","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.ajcnut.2025.06.013","article-title":"Prospective association of the EAT-Lancet reference diet with body weight changes and incidence of overweight and obesity in a French cohort.","volume":"122","author":"Berthy","year":"2025","journal-title":"Am J Clin Nutr."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.3390\/healthcare13141641","article-title":"Dietary habits, TCM constitutions, and obesity: investigating the protective effects of vegetarian dietary patterns in Taiwan.","volume":"13","author":"Huang","year":"2025","journal-title":"Healthcare."},{"key":"B4","doi-asserted-by":"publisher","first-page":"368504251320313","DOI":"10.1177\/00368504251320313","article-title":"Virtual screening combined with molecular docking for the !identification of new anti-adipogenic compounds.","volume":"108","author":"Mandujano-L\u00e1zaro","year":"2025","journal-title":"Sci Prog"},{"key":"B5","doi-asserted-by":"publisher","first-page":"100718","DOI":"10.1016\/j.jlr.2024.100718","article-title":"Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition.","volume":"66","author":"Fu","year":"2025","journal-title":"J Lipid Res"},{"key":"B6","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1093\/ejendo\/lvaf081","article-title":"Bariatric surgery promotes recruitment of brown fat linked to alterations in the gut microbiota.","volume":"192","author":"Herz","year":"2025","journal-title":"Eur J Endocrinol"},{"key":"B7","doi-asserted-by":"crossref","first-page":"9636897251346599","DOI":"10.1177\/09636897251346599","article-title":"Application of human iPSC-derived white, beige, and brown adipocytes for metabolic disease modeling and transplantation therapy.","volume":"34","author":"Keidai","year":"2025","journal-title":"Cell Transplant."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1546456","DOI":"10.3389\/fphar.2025.1546456","article-title":"Development of an adipocyte differentiation protocol using 3T3-L1 cells for the investigation of the browning process: identification of the PPAR-\u03b3 agonist rosiglitazone as a browning reference drug.","volume":"16","author":"Flori","year":"2025","journal-title":"Front Pharmacol"},{"key":"B9","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1111\/apt.70020","article-title":"Addressing the high and rising global burden of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH): from the growing prevalence to payors\u2019.","volume":"61","author":"Younossi","year":"2025","journal-title":"Perspect Aliment Pharmacol Ther."},{"key":"B10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.clnesp.2025.06.035","article-title":"Optimizing weight loss with artificial intelligence: a randomized controlled trial of dietary-supplement prescriptions in adults with overweight and obesity.","volume":"69","author":"Pokushalov","year":"2025","journal-title":"Clin Nutr ESPEN."},{"key":"B11","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.clnu.2024.12.031","article-title":"Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: a randomized, double-blinded placebo-controlled clinical trial.","volume":"45","author":"Marques","year":"2025","journal-title":"Clin Nutr."},{"key":"B12","doi-asserted-by":"publisher","first-page":"7974","DOI":"10.1080\/07391102.2025.2460738","article-title":"Mitochondrial function, cell viability, pharmacokinetics and molecular simulation studies reveal the impact of CX-6258 HCl, a pan-Pim kinase inhibitor, on adipocytes.","volume":"43","author":"Reyad-Ul Ferdous","year":"2025","journal-title":"J Biomol Struct Dyn"},{"key":"B13","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1056\/NEJMoa2410819","article-title":"Tirzepatide for obesity treatment and diabetes prevention.","volume":"392","author":"Jastreboff","year":"2025","journal-title":"N Engl J Med."},{"key":"B14","doi-asserted-by":"publisher","first-page":"18","DOI":"10.24875\/GMM.M25000973","article-title":"Nutritional genomics in the Mexican population. An approach to prevent the development of obesity-associated metabolic diseases.","volume":"161","author":"Aguilar-Salazar","year":"2025","journal-title":"Gac Med Mex"},{"key":"B15","doi-asserted-by":"publisher","first-page":"9100","DOI":"10.1038\/s41467-024-53118-3","article-title":"Annonaceous acetogenins mimic AA005 targets mitochondrial trifunctional enzyme alpha subunit to treat obesity in male mice.","volume":"15","author":"Han","year":"2024","journal-title":"Nat Commun."},{"key":"B16","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/978-3-031-63657-8_4","article-title":"Lipid storage, lipolysis, and lipotoxicity in obesity.","volume":"1460","author":"Engin","year":"2024","journal-title":"Adv Exp Med Biol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"e70001","DOI":"10.1002\/cph4.70001","article-title":"Immune regulatory crosstalk in adipose tissue thermogenesis.","volume":"15","author":"Yildiz","year":"2025","journal-title":"Compr Physiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"C2079","DOI":"10.1152\/ajpcell.00661.2025","article-title":"Adipo-epithelial transdifferentiation: old data and new perspectives.","volume":"329","author":"Cinti","year":"2025","journal-title":"Am J Physiol Cell Physiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"4051","DOI":"10.1038\/s41598-025-87945-1","article-title":"Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential.","volume":"15","author":"Inthanon","year":"2025","journal-title":"Sci Rep"},{"key":"B20","doi-asserted-by":"publisher","first-page":"107985","DOI":"10.7554\/eLife.99782","article-title":"Cell-state-dependent regulation of PPAR\u03b3 signaling by the transcription factor ZBTB9 in adipocytes.","volume":"300","author":"Xu","year":"2024","journal-title":"J Biol Chem."},{"key":"B21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00438-025-02243-9","article-title":"PPAR \u03b3 changing ALDH1A3 content to regulate lipid metabolism and inhibit lung cancer cell growth.","volume":"300","author":"Tian","year":"2025","journal-title":"Mol Genet Genomics."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1502751","DOI":"10.3389\/fmicb.2024.1502751","article-title":"Fermented sugarcane juice-derived probiotic Levilactobacillus brevis RAMULAB54 enhances lipid metabolism and glucose homeostasis through PPAR-\u03b3 activation.","volume":"15","author":"Kumari","year":"2024","journal-title":"Front Microbiol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1497023","DOI":"10.3389\/fmicb.2024.1497023","article-title":"Cell-free supernatant of Levilactobacillus brevis (RAMULAB51) from coconut inflorescence sap (Neera) enhances glucose uptake and PPAR-\u03b3 in 3T3-L1 adipocytes and inhibits \u03b1-glucosidase and \u03b1-amylase.","volume":"15","author":"Kumari","year":"2024","journal-title":"Front Microbiol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"12161","DOI":"10.3390\/ijms252212161","article-title":"The protective role of miR-130b-3p against palmitate-induced lipotoxicity in cardiomyocytes through PPAR\u03b3 Pathway.","volume":"25","author":"Alonso-Villa","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B25","doi-asserted-by":"publisher","first-page":"120108","DOI":"10.1016\/j.jep.2025.120108","article-title":"Hepatoprotective activity of mulberry extract in NAFLD mice for regulating lipid metabolism and inflammation identified via AMPK\/PPAR-\u03b3\/NF-\u03baB axis.","volume":"351","author":"Zhang","year":"2025","journal-title":"J Ethnopharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1080\/19768354.2025.2536022","article-title":"Zanthoxylum schinifolium extracts enhance 3T3-L1 adipocyte differentiation via CHOP inhibition and PPAR\u03b3 activation.","volume":"29","author":"Lee","year":"2025","journal-title":"Anim Cells Syst."},{"key":"B27","doi-asserted-by":"publisher","first-page":"3482","DOI":"10.1039\/d4fo04976d","article-title":"Effect of different ratios of carbohydrate to fat intake on glucolipid metabolism in developing mice.","volume":"16","author":"Shao","year":"2025","journal-title":"Food Funct"},{"key":"B28","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1186\/s12931-024-02935-7","article-title":"It takes two peroxisome proliferator-activated receptors (PPAR-\u03b2\/\u03b4 and PPAR-\u03b3) to tango idiopathic pulmonary fibrosis.","volume":"25","author":"Boateng","year":"2024","journal-title":"Respir Res."},{"key":"B29","doi-asserted-by":"crossref","first-page":"113992","DOI":"10.1016\/j.yexcr.2024.113992","article-title":"Notoginsenoside R1 targets PPAR-\u03b3 to inhibit hepatic stellate cell activation and ameliorates liver fibrosis.","volume":"437","author":"Guo","year":"2024","journal-title":"Exp Cell Res."},{"key":"B30","doi-asserted-by":"publisher","first-page":"156975","DOI":"10.1016\/j.phymed.2025.156975","article-title":"Protective effects of pollenin B in asthma: ppar-\u03b3-mediated regulation of inflammatory pathways and arachidonic acid metabolism.","volume":"145","author":"Wu","year":"2025","journal-title":"Phytomedicine"},{"key":"B31","doi-asserted-by":"publisher","first-page":"149366","DOI":"10.1016\/j.brainres.2024.149366","article-title":"Peroxisome proliferator-activated receptor gamma: a promising therapeutic target for the treatment of chronic pain.","volume":"1850","author":"Liu","year":"2025","journal-title":"Brain Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"3063","DOI":"10.3390\/nu16183063","article-title":"Impact of sex on the therapeutic efficacy of rosiglitazone in modulating white adipose tissue function and insulin sensitivity.","volume":"16","author":"Bauz\u00e1-Thorbr\u00fcgge","year":"2024","journal-title":"Nutrients"},{"key":"B33","doi-asserted-by":"publisher","first-page":"116939","DOI":"10.1016\/j.ejmech.2024.116939","article-title":"Reversal of insulin resistance to combat type 2 diabetes mellitus by newer thiazolidinedione\u2019s in fructose induced insulin resistant rats.","volume":"280","author":"Ranade","year":"2024","journal-title":"Eur J Med Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1007\/s00380-024-02363-z","article-title":"Impact of pemafibrate on lipid profile and insulin resistance in hypertriglyceridemic patients with coronary artery disease and metabolic syndrome.","volume":"39","author":"Nakamura","year":"2024","journal-title":"Heart Vessels"},{"key":"B35","doi-asserted-by":"crossref","first-page":"8729","DOI":"10.1021\/acs.jmedchem.5c00402","article-title":"Structure-based design and optimization lead to the identification of a novel potent sEH inhibitor with PPAR\u03b3 partial agonist activity against inflammatory and metabolic-related diseases.","volume":"68","author":"Cao","year":"2025","journal-title":"J Med Chem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"118264","DOI":"10.1016\/j.ejmech.2025.118264","article-title":"Structural and functional insights into PPAR-\u03b3: review of its potential and drug design innovations for the development of antidiabetic agents.","volume":"302","author":"Gupta","year":"2026","journal-title":"Eur J Med Chem"},{"key":"B37","doi-asserted-by":"publisher","first-page":"494","DOI":"10.3390\/antiox14040494","article-title":"Competitive ligand-induced recruitment of coactivators to specific PPAR\u03b1\/\u03b4\/\u03b3 ligand-binding domains revealed by dual-emission FRET and X-ray diffraction of cocrystals.","volume":"14","author":"Kamata","year":"2025","journal-title":"Antioxidants."},{"key":"B38","doi-asserted-by":"publisher","first-page":"10622","DOI":"10.1039\/d4ra09055a","article-title":"Unraveling PPAR\u03b2\/\u03b4 nuclear receptor agonists via a drug-repurposing approach: htvs-based ligand identification, molecular dynamics, pharmacokinetics, and in vitro anti-steatotic validation.","volume":"15","author":"Mandal","year":"2025","journal-title":"RSC Adv"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1111\/jgh.16929","article-title":"PPAR\u03b3\/\u03b2\/\u03b4 agonists can ameliorate dextran sodium sulfate-induced colitis and modulate gut microbiota.","volume":"40","author":"Li","year":"2025","journal-title":"J Gastroenterol Hepatol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"114616","DOI":"10.1016\/j.intimp.2025.114616","article-title":"Potentials of peroxisome proliferator-activated receptor (PPAR) \u03b1, \u03b2\/\u03b4, and \u03b3: an in-depth and comprehensive review of their molecular mechanisms, cellular Signalling, immune responses and therapeutic implications in multiple diseases.","volume":"155","author":"Singh","year":"2025","journal-title":"Int Immunopharmacol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2036","DOI":"10.3168\/jds.2024-25575","article-title":"Potential involvement of peroxisome proliferator-activated receptors in the inhibition of mammary lipid synthesis during diet-induced milk fat depression.","volume":"108","author":"Haile","year":"2025","journal-title":"J Dairy Sci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3390\/molecules30020419","article-title":"Phenolic and iridoid glycosides from Leonurus cardiaca L. and their effects on the \u03b1, \u03b4, and \u03b3 subtypes of the PPAR system-including the discovery of the novel phenylethanoid cardiaphenyloside A and the most active 7-chloro-6-desoxy-harpagide.","volume":"30","author":"Kuchta","year":"2025","journal-title":"Molecules"},{"key":"B43","doi-asserted-by":"crossref","first-page":"2497112","DOI":"10.1080\/07853890.2025.2497112","article-title":"PPAR-mediated reduction of lipid accumulation in hepatocytes involves the autophagy-lysosome-mitochondrion axis.","volume":"57","author":"Cetti","year":"2025","journal-title":"Ann Med."},{"key":"B44","doi-asserted-by":"crossref","first-page":"e70274","DOI":"10.1002\/jbt.70274","article-title":"Kallistatin improves lipid metabolism and alleviates cardiac hypertrophy via the SIRT1\/PPAR pathway: an experimental study.","volume":"39","author":"Li","year":"2025","journal-title":"J Biochem Mol Toxicol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"116830","DOI":"10.1016\/j.jpba.2025.116830","article-title":"Black rice bran improved lipid metabolism in hyperlipidemia mice via steroid hormone biosynthesis and PPAR signaling pathway.","volume":"262","author":"Li","year":"2025","journal-title":"J Pharm Biomed Anal."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.3390\/nu17101693","article-title":"A novel camel milk-derived peptide LLPK improves glucose-lipid metabolism in db\/ db mice via PPAR signaling pathway.","volume":"17","author":"Han","year":"2025","journal-title":"Nutrients"},{"key":"B47","doi-asserted-by":"publisher","first-page":"482","DOI":"10.3390\/antiox14040482","article-title":"Involvement of nuclear receptors PPAR-\u03b1, PPAR-\u03b3, and the transcription factor Nrf2 in cellular protection against oxidative stress regulated by HS and induced by hypoxia-reoxygenation and high glucose in primary cardiomyocyte cultures.","volume":"14","author":"Ibarra-Lara","year":"2025","journal-title":"Antioxidants."},{"key":"B48","doi-asserted-by":"publisher","first-page":"177186","DOI":"10.1016\/j.ejphar.2024.177186","article-title":"Protective effects of the PPAR agonist bezafibrate against disruption of redox and energy homeostasis, neuronal death, astroglial reactivity, and neuroinflammation induced in vivo by D-2-hydroxyglutaric acid in rat brain.","volume":"987","author":"Ribeiro","year":"2025","journal-title":"Eur J Pharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"26995","DOI":"10.1038\/s41598-025-12357-0","article-title":"In silico and in vitro investigations reveal pan-PPAR agonist activity and anti-NAFLD efficacy of polydatin by modulating hepatic lipid-energy metabolism.","volume":"15","author":"Mandal","year":"2025","journal-title":"Sci Rep"},{"key":"B50","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1111\/jgh.17033","article-title":"Modulation of lipid metabolism and keap1-Nrf2 pathway activation in macrophages by targeting PPAR\u03b3 Affects NAFLD progression.","volume":"40","author":"Chen","year":"2025","journal-title":"J Gastroenterol Hepatol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"125785","DOI":"10.1016\/j.envpol.2025.125785","article-title":"6-PPD triggered lipid metabolism disorder and inflammatory response in larval zebrafish (Danio rerio) by regulating PPAR\u03b3\/NF-\u03baB pathway.","volume":"368","author":"Qian","year":"2025","journal-title":"Environ Pollut"},{"key":"B52","doi-asserted-by":"publisher","first-page":"106631","DOI":"10.1016\/j.jsbmb.2024.106631","article-title":"Panax notoginseng saponins improves lipid metabolism and prevents atherosclerosis in mice with steroid-resistant lupus nephritis via the SIRT1\/PPAR\u03b3 signaling pathway.","volume":"245","author":"Xu","year":"2025","journal-title":"J Steroid Biochem Mol Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s12944-025-02490-0","article-title":"Arachidonic acid suppresses lung cancer cell growth and modulates lipid metabolism and the ERK\/PPAR\u03b3 signaling pathway.","volume":"24","author":"Wang","year":"2025","journal-title":"Lipids Health Dis."},{"key":"B54","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s12974-025-03495-3","article-title":"N-Lactoyl-Phenylalanine modulates lipid metabolism in microglia\/macrophage via the AMPK-PGC1\u03b1-PPAR\u03b3 pathway to promote recovery in mice with spinal cord injury.","volume":"22","author":"Ying","year":"2025","journal-title":"J Neuroinflammation"},{"key":"B55","doi-asserted-by":"publisher","first-page":"154194","DOI":"10.1016\/j.tox.2025.154194","article-title":"Nanoplastics disrupt hepatic lipid metabolism via the inhibition of PPAR\u03b3: a study based on digestive system exposure.","volume":"516","author":"Xu","year":"2025","journal-title":"Toxicology."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1681","DOI":"10.1007\/s00210-024-03301-6","article-title":"Protective effect of irbesartan against hepatic ischemia-reperfusion injury in rats: role of ERK, STAT3, and PPAR-\u03b3 inflammatory pathways in rats.","volume":"398","author":"El-Marasy","year":"2025","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"B57","doi-asserted-by":"crossref","first-page":"111688","DOI":"10.1016\/j.diabres.2024.111688","article-title":"MASLD\/MASH and type 2 diabetes: two sides of the same coin? From single PPAR to pan-PPAR agonists.","volume":"212","author":"Cooreman","year":"2024","journal-title":"Diabetes Res Clin Pract."},{"key":"B58","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/j.jare.2025.04.010","article-title":"ARHGEF3 coordinates adipocyte hypertrophy and differentiation through dual YAP-RhoA and PPAR\u03b3 activation.","volume":"79","author":"Khaliq","year":"2025","journal-title":"J Adv Res"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e0316417","DOI":"10.1371\/journal.pone.0316417","article-title":"Cnot4 heterozygosity attenuates high fat diet-induced obesity in mice and impairs PPAR\u03b3-mediated adipocyte differentiation.","volume":"20","author":"Yamaguchi","year":"2025","journal-title":"PLoS One."},{"key":"B60","first-page":"493","article-title":"[Research progress on the effect of miRNA-mediated PPAR\u03b3-related signaling pathways on lipid metabolism in steroid-induced osteonecrosis of femoral head].","volume":"77","author":"Gao","year":"2025","journal-title":"Sheng Li Xue Bao."},{"key":"B61","doi-asserted-by":"publisher","first-page":"103785","DOI":"10.1016\/j.numecd.2024.10.023","article-title":"Effect of dietary protein on serum hepcidin and iron in adults with obesity and insulin resistance: a randomized single blind clinical trial.","volume":"35","author":"Gonz\u00e1lez-Salazar","year":"2025","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"B62","doi-asserted-by":"publisher","first-page":"2449027","DOI":"10.1080\/21623945.2024.2449027","article-title":"Anti-inflammatory effect of Angiotensin 1-7 in white adipose tissue.","volume":"14","author":"Nishida","year":"2025","journal-title":"Adipocyte"},{"key":"B63","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1080\/08923973.2024.2430668","article-title":"BACE1 inhibition via miR-6838-5p overexpression inhibits insulin resistance and the immune response in HFD-induced obesity in mice model.","volume":"47","author":"Han","year":"2025","journal-title":"Immunopharmacol Immunotoxicol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"e60838","DOI":"10.2196\/60838","article-title":"Exploring molecular genetics research on obesity in Malaysia: protocol for a scoping review.","volume":"13","author":"Ahmad Zamri","year":"2024","journal-title":"JMIR Res Protoc"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.3390\/genes15101334","article-title":"Genetic variants of obesity in Malaysia: a scoping review.","volume":"15","author":"Hamzah","year":"2024","journal-title":"Genes."},{"key":"B66","doi-asserted-by":"publisher","first-page":"85","DOI":"10.24875\/GMM.M25000984","article-title":"Genetic influence on obesity: beyond bad habits in the Mexican population.","volume":"161","author":"Moreno-Celis","year":"2025","journal-title":"Gac Med Mex"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.3390\/genes15091137","article-title":"Comprehensive genetic analysis of associations between obesity-related parameters and physical activity: a scoping review.","volume":"15","author":"Leo\u00f1ska-Duniec","year":"2024","journal-title":"Genes."},{"key":"B68","first-page":"110","article-title":"High frequency of metabolic syndrome in non-obese Maya children from M\u00e9xico: implications of PPARG, KCNJ1, HHEX, HNF4A, ACE (I\/D), FTO and ABCA1 genetics variants.","volume":"161","author":"Pe\u00f1a-Espinoza","year":"2025","journal-title":"Gac Med Mex."},{"key":"B69","doi-asserted-by":"publisher","first-page":"13303","DOI":"10.1021\/acsomega.4c11128","article-title":"From apo to ligand-bound: unraveling PPAR\u03b3-LBD conformational shifts via advanced molecular dynamics.","volume":"10","author":"Falbo","year":"2025","journal-title":"ACS Omega"},{"key":"B70","doi-asserted-by":"publisher","first-page":"R99782","DOI":"10.7554\/eLife.99782","article-title":"Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR\u03b3.","volume":"13","author":"Shang","year":"2024","journal-title":"Elife"},{"key":"B71","doi-asserted-by":"publisher","first-page":"116908","DOI":"10.1016\/j.bcp.2025.116908","article-title":"Understanding the peroxisome proliferator-activated receptor gamma (PPAR-\u03b3) role in periodontitis and diabetes mellitus: a molecular perspective.","volume":"237","author":"Nicchio","year":"2025","journal-title":"Biochem Pharmacol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"19207","DOI":"10.1038\/s41598-025-03387-9","article-title":"Design and synthesis of a novel quinoline thiazolidinedione hybrid as a potential antidiabetic PPAR\u03b3 modulator.","volume":"15","author":"Ibrahim","year":"2025","journal-title":"Sci Rep"},{"key":"B73","doi-asserted-by":"publisher","first-page":"3940","DOI":"10.3390\/ijms24043940","article-title":"Structural biology inspired development of a series of human peroxisome proliferator-activated receptor gamma (PPAR\u03b3) ligands: from agonist to antagonist.","volume":"24","author":"Miyachi","year":"2023","journal-title":"Int J Mol Sci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1038\/s41419-023-06283-0","article-title":"Deciphering the interaction between Twist1 and PPAR\u03b3 during adipocyte differentiation.","volume":"14","author":"Sun","year":"2023","journal-title":"Cell Death Dis"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1716","DOI":"10.3390\/foods14101716","article-title":"Ginseng soluble dietary fiber reverses obesity via the PPAR\/AMPK signaling pathway and improves intestinal flora in mice.","volume":"14","author":"Zhang","year":"2025","journal-title":"Foods"},{"key":"B76","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1038\/s41430-024-01512-x","article-title":"Expression of PGC-1\u03b1, PPAR-\u03b1 and UCP1 genes, metabolic and anthropometric factors in response to sodium butyrate supplementation in patients with obesity: a triple-blind, randomized placebo-controlled clinical trial.","volume":"79","author":"Amiri","year":"2025","journal-title":"Eur J Clin Nutr"},{"key":"B77","doi-asserted-by":"publisher","first-page":"177306","DOI":"10.1016\/j.ejphar.2025.177306","article-title":"The PPAR-\u03b1 agonist oleoyethanolamide (OEA) ameliorates valproic acid-induced steatohepatitis in rats via suppressing Wnt3a\/\u03b2-catenin and activating PGC-1\u03b1: Involvement of network pharmacology and molecular docking.","volume":"991","author":"El Tabaa","year":"2025","journal-title":"Eur J Pharmacol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"2613","DOI":"10.3390\/ijms26062613","article-title":"HIF-3\u03b1\/PPAR-\u03b3 regulates hypoxia tolerance by altering glycolysis and lipid synthesis in blunt snout bream (Megalobrama amblycephala).","volume":"26","author":"Jiang","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B79","doi-asserted-by":"publisher","first-page":"115165","DOI":"10.1016\/j.celrep.2024.115165","article-title":"The adiponectin-PPAR\u03b3 axis in hepatic stellate cells regulates liver fibrosis.","volume":"44","author":"Zhao","year":"2025","journal-title":"Cell Rep"},{"key":"B80","doi-asserted-by":"publisher","first-page":"101287","DOI":"10.1016\/j.gendis.2024.101287","article-title":"MicroRNAs in adipose tissue fibrosis: mechanisms and therapeutic potential.","volume":"12","author":"Tian","year":"2025","journal-title":"Genes Dis"},{"key":"B81","first-page":"333","article-title":"[Pachymic acid promotes brown\/beige adipocyte differentiation and lipid metabolism in preadipocytes].","volume":"54","author":"Chen","year":"2025","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban."},{"key":"B82","doi-asserted-by":"publisher","first-page":"7957","DOI":"10.1038\/s41467-024-51938-x","article-title":"IL-1\u03b2 promotes adipogenesis by directly targeting adipocyte precursors.","volume":"15","author":"Hofwimmer","year":"2024","journal-title":"Nat Commun"},{"key":"B83","doi-asserted-by":"publisher","first-page":"e70122","DOI":"10.1111\/apha.70122","article-title":"Is Predisposition to T2D impacted by polymorphisms in genes involved in insulin signaling and cellular bioenergetics?","volume":"241","author":"Pati","year":"2025","journal-title":"Acta Physiol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"101699","DOI":"10.1016\/j.gendis.2025.101699","article-title":"CMTM3 promotes adipocyte differentiation by regulating PPAR\u03b3 in 3T3-L1 cells.","volume":"12","author":"Zhao","year":"2025","journal-title":"Genes Dis"},{"key":"B85","doi-asserted-by":"publisher","first-page":"140121","DOI":"10.1016\/j.ijbiomac.2025.140121","article-title":"Erucic acid promotes intramuscular fat deposition through the PPAR\u03b3-FABP4\/CD36 pathway.","volume":"298","author":"Yu","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"114945","DOI":"10.1016\/j.celrep.2024.114945","article-title":"PPAR\u03b3-dependent remodeling of translational machinery in adipose progenitors is impaired in obesity.","volume":"43","author":"De Siqueira","year":"2024","journal-title":"Cell Rep"},{"key":"B87","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.jhep.2024.12.045","article-title":"Pan-PPAR agonist lanifibranor improves insulin resistance and hepatic steatosis in patients with T2D and MASLD.","volume":"82","author":"Barb","year":"2025","journal-title":"J Hepatol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"4535","DOI":"10.1016\/j.apsb.2023.07.001","article-title":"Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS\/PPAR \u03b3\/FABP4 signaling in mice.","volume":"13","author":"Tang","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"B89","doi-asserted-by":"crossref","first-page":"28118","DOI":"10.1038\/s41598-024-73969-6","article-title":"Activation of the mTOR pathway enhances PPAR\u03b3\/SREBP-mediated lipid synthesis in human meibomian gland epithelial cells.","volume":"14","author":"Jun","year":"2024","journal-title":"Sci Rep."},{"key":"B90","doi-asserted-by":"publisher","first-page":"e70086","DOI":"10.1111\/jcmm.70086","article-title":"Tetracarpidium conophorum nuts (African walnuts) up-regulated adiponectin and PPAR-\u03b3 expressions with reciprocal suppression of TNF-\u03b1 gene in obesity.","volume":"28","author":"Umoru","year":"2024","journal-title":"J Cell Mol Med"},{"key":"B91","doi-asserted-by":"crossref","first-page":"159632","DOI":"10.1016\/j.bbalip.2025.159632","article-title":"Adiponectin receptor agonist AdipoRon regulates glucose and lipid metabolism via PPAR\u03b3 signaling pathway in hepatocytes of large yellow croaker (Larimichthys crocea).","volume":"1870","author":"Xu","year":"2025","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids."},{"key":"B92","doi-asserted-by":"publisher","first-page":"26991","DOI":"10.1038\/s41598-025-12547-w","article-title":"Regulatory effects of specialized metabolites from Dendrobium albosanguineum on lipid metabolism and adipocyte differentiation.","volume":"15","author":"Wuttiin","year":"2025","journal-title":"Sci Rep"},{"key":"B93","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s10695-017-0424-6","article-title":"Dietary docosahexaenoic acid decreased lipid accumulation via inducing adipocytes apoptosis of grass carp, Ctenopharygodon idella.","volume":"44","author":"Jin","year":"2018","journal-title":"Fish Physiol Biochem"},{"key":"B94","doi-asserted-by":"publisher","first-page":"102114","DOI":"10.1016\/j.molmet.2025.102114","article-title":"Adipocyte Septin-7 attenuates obesogenic adipogenesis and promotes lipolysis to prevent obesity.","volume":"95","author":"Xu","year":"2025","journal-title":"Mol Metab"},{"key":"B95","doi-asserted-by":"publisher","first-page":"106848","DOI":"10.1016\/j.domaniend.2024.106848","article-title":"Insulin interacts with PPAR\u03b3 agonists to promote bovine adipocyte differentiation.","volume":"88","author":"Guo","year":"2024","journal-title":"Domest Anim Endocrinol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3390\/ncrna10020024","article-title":"miRNAs as interconnectors between obesity and cancer.","volume":"10","author":"Gonz\u00e1lez-S\u00e1nchez","year":"2024","journal-title":"Noncoding RNA"},{"key":"B97","doi-asserted-by":"crossref","first-page":"156194","DOI":"10.1016\/j.metabol.2025.156194","article-title":"LINC00278 and BRG1: a key regulatory axis in male obesity and preadipocyte adipogenesis.","volume":"168","author":"Zhang","year":"2025","journal-title":"Metabolism."},{"key":"B98","doi-asserted-by":"publisher","first-page":"156111","DOI":"10.1016\/j.metabol.2024.156111","article-title":"NORAD exacerbates metabolic dysfunction-associated steatotic liver disease development via the miR-511-3p\/Rock2 axis and inhibits ubiquitin-mediated degradation of ROCK2.","volume":"164","author":"Zhang","year":"2025","journal-title":"Metabolism"},{"key":"B99","doi-asserted-by":"crossref","first-page":"2474114","DOI":"10.1080\/21623945.2025.2474114","article-title":"miR-6402 targets Bmpr2 and negatively regulates mouse adipogenesis.","volume":"14","author":"Elsheikh","year":"2025","journal-title":"Adipocyte."},{"key":"B100","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.semcancer.2025.06.005","article-title":"The converging roles of microRNAs and lipid metabolism in atherosclerotic cardiovascular disease and cancer.","volume":"114","author":"Vladimirov","year":"2025","journal-title":"Semin Cancer Biol"},{"key":"B101","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3390\/vetsci12040375","article-title":"Ssc-miR-130b enhances cell proliferation and represses adipogenesis of primary cultured intramuscular preadipocytes in pigs.","volume":"12","author":"Yang","year":"2025","journal-title":"Vet Sci."},{"key":"B102","doi-asserted-by":"publisher","first-page":"R96988","DOI":"10.7554\/eLife.96988","article-title":"LncRNA Snhg3 aggravates hepatic steatosis via PPAR\u03b3 signaling.","volume":"13","author":"Xie","year":"2024","journal-title":"Elife"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1529797","DOI":"10.3389\/fgene.2025.1529797","article-title":"LncRNA H19 promotes adipogenic differentiation disorder by sponging miR-130b-3p to upregulate PPAR\u03b3 in steroid-induced osteonecrosis of the femoral head.","volume":"16","author":"Lin","year":"2025","journal-title":"Front Genet."},{"key":"B104","doi-asserted-by":"publisher","first-page":"e2401939","DOI":"10.1002\/advs.202401939","article-title":"The long non-coding RNA Obesity-Related (Obr) contributes to lipid metabolism through epigenetic regulation.","volume":"11","author":"Kaimala","year":"2024","journal-title":"Adv Sci"},{"key":"B105","doi-asserted-by":"publisher","first-page":"1405588","DOI":"10.3389\/fgene.2024.1405588","article-title":"Long non-coding RNA (LncRNA) and epigenetic factors: their role in regulating the adipocytes in bovine.","volume":"15","author":"Jilo","year":"2024","journal-title":"Front Genet."},{"key":"B106","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1002\/prot.70022","article-title":"The SIRT1 N-terminal domain as a common binding interface for PPAR\u03b3 anchoring.","volume":"93","author":"Malospirito","year":"2025","journal-title":"Proteins"},{"key":"B107","doi-asserted-by":"publisher","first-page":"3476","DOI":"10.1038\/s41388-025-03492-z","article-title":"PPAR\u03b3 acetylation governs mammary adenocarcinoma tumor growth via acetylated residues that determine DNA sequence-specific binding.","volume":"44","author":"Tian","year":"2025","journal-title":"Oncogene."},{"key":"B108","doi-asserted-by":"publisher","first-page":"5239","DOI":"10.2147\/DDDT.S490772","article-title":"Fenofibrate as an Adjunct Therapy for Ulcerative Colitis: targeting Inflammation via SIRT1, NLRP3, and AMPK Pathways: a Randomized Controlled Pilot Study.","volume":"18","author":"Alarfaj","year":"2024","journal-title":"Drug Des Devel Ther"},{"key":"B109","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.clnesp.2023.10.013","article-title":"Effects of oleoylethanolamide supplementation on the expression of lipid metabolism-related genes and serum NRG4 levels in patients with non-alcoholic fatty liver disease: a randomized controlled trial.","volume":"58","author":"Tutunchi","year":"2023","journal-title":"Clin Nutr ESPEN"},{"key":"B110","doi-asserted-by":"crossref","first-page":"109851","DOI":"10.1016\/j.jnutbio.2025.109851","article-title":"Lactucin and lactucopicrin ameliorate obesity in high-fat diet fed mice by promoting white adipose tissue browning through the activation of the AMPK\/SIRT1\/PGC-1\u03b1 pathway.","volume":"139","author":"Zhong","year":"2025","journal-title":"J Nutr Biochem."},{"key":"B111","doi-asserted-by":"publisher","first-page":"156073","DOI":"10.1016\/j.prp.2025.156073","article-title":"Molecular epigenetics in the transition of white to brown fat.","volume":"272","author":"Chaturvedi","year":"2025","journal-title":"Pathol Res Pract."},{"key":"B112","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1007\/s11064-025-04469-w","article-title":"Palmitic acid induces dynamic time-dependent alterations in HDACs, neuronal chromatin acetylation, and gene expression.","volume":"50","author":"Rueda-D\u00edaz","year":"2025","journal-title":"Neurochem Res"},{"key":"B113","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1007\/s11427-024-2827-y","article-title":"A novel deacetylase inhibitor KLX suppresses liver fibrosis by deacetylating PPAR\u03b3 through promoting ubiquitination-mediated HDAC1 degradation.","volume":"68","author":"Zhang","year":"2025","journal-title":"Sci China Life Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1491160","DOI":"10.3389\/fvets.2024.1491160","article-title":"Profile of miRNAs induced during sheep fat tail development and roles of four key miRNAs in proliferation and differentiation of sheep preadipocytes.","volume":"11","author":"Zhang","year":"2024","journal-title":"Front Vet Sci."},{"key":"B115","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.12122\/j.issn.1673-4254.2024.09.13","article-title":"[Effects of chronic intermittent hypoxia and reoxygenation on insulin resistance and skeletal muscle miR-27a-3p\/PPAR\u03b3\/IRS1\/PI3K\/AKT expressions in rats].","volume":"44","author":"Zhou","year":"2024","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"B116","doi-asserted-by":"publisher","first-page":"103156","DOI":"10.1186\/s13148-015-0149-2","article-title":"MicroRNA-34a and promoter methylation contribute to peroxisome proliferator-activated receptor gamma gene expression in patients with type 2 diabetes.","volume":"18","author":"Moghadasi","year":"2024","journal-title":"Diabetes Metab Syndr."},{"key":"B117","doi-asserted-by":"publisher","first-page":"27779","DOI":"10.1038\/s41598-025-11324-z","article-title":"Dysregulation of adipocytokines via the hsa-miR-548ay-3p\/PPAR\u03b3 signaling pathway leads to cardiac fibrosis.","volume":"15","author":"Chen","year":"2025","journal-title":"Sci Rep"},{"key":"B118","doi-asserted-by":"publisher","first-page":"150447","DOI":"10.1016\/j.bbrc.2024.150447","article-title":"Exercise training-driven exosomal miRNA-323-5p activity suppresses adipogenic conversion of 3T3-L1 cells via the DUSP3\/ERK pathway.","volume":"734","author":"Osawa","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"B119","doi-asserted-by":"publisher","first-page":"148270","DOI":"10.1016\/j.ijbiomac.2025.148270","article-title":"Role of lncRNAs H19, KCNQ1OT1 and SRA in relation to peroxisome proliferator-activated receptor gamma in the occurrence and progression of non-alcoholic fatty pancreas disease in obese and non-obese Egyptian patients.","volume":"331","author":"Zayed","year":"2025","journal-title":"Int J Biol Macromol"},{"key":"B120","doi-asserted-by":"publisher","first-page":"e170072","DOI":"10.1172\/JCI170072","article-title":"A PPAR\u03b3\/long noncoding RNA axis regulates adipose thermoneutral remodeling in mice.","volume":"133","author":"Zhang","year":"2023","journal-title":"J Clin Invest"},{"key":"B121","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.bbrc.2022.02.069","article-title":"Transcriptome analysis of long non-coding RNAs reveals NR_015556 lncRNA is a novel regulator for adipocyte differentiation.","volume":"601","author":"Zuo","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1093\/mr\/roae015","article-title":"lncRNA OIP5-AS1 promotes mitophagy to alleviate osteoarthritis by upregulating PPAR-\u03b3 to activate the AMPK\/Akt\/mTOR pathway.","volume":"34","author":"Sun","year":"2024","journal-title":"Mod Rheumatol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"118942","DOI":"10.1016\/j.lfs.2020.118942","article-title":"LncRNA Blnc1 mediates the permeability and inflammatory response of cerebral hemorrhage by regulating the PPAR-\u03b3\/SIRT6\/FoxO3 pathway.","volume":"267","author":"Xie","year":"2021","journal-title":"Life Sci"},{"key":"B124","doi-asserted-by":"publisher","first-page":"110903","DOI":"10.1016\/j.cellsig.2023.110903","article-title":"Bioinformatic analysis and verification of a lipid metabolism-related long noncoding RNA prognostic signature for head and neck squamous cell carcinoma.","volume":"112","author":"Yuan","year":"2023","journal-title":"Cell Signal"},{"key":"B125","doi-asserted-by":"publisher","first-page":"108","DOI":"10.22088\/IJMCM.BUMS.12.2.108","article-title":"Mesenchymal stem cells therapy led to the improvement of spatial memory in rats with Alzheimer\u2019s disease through changing the expression of LncRNA TUSC7\/ miR-449a\/ PPAR\u03b3 and CD36 genes in the brain tissue.","volume":"12","author":"Pezeshki","year":"2023","journal-title":"Int J Mol Cell Med"},{"key":"B126","doi-asserted-by":"publisher","first-page":"2897","DOI":"10.1007\/s10068-025-01915-x","article-title":"Exploring the inhibitory effects of Brassica juncea extract and sinigrin on lipid accumulation in BPA-Induced 3T3-L1 cells via the glucocorticoid receptor and peroxisome proliferator-activated receptor-\u03b3 pathways.","volume":"34","author":"Im","year":"2025","journal-title":"Food Sci Biotechnol"},{"key":"B127","doi-asserted-by":"publisher","first-page":"177972","DOI":"10.1016\/j.scitotenv.2024.177972","article-title":"Black phosphorus quantum dots induce lipid accumulation through PPAR\u03b3 activation and mitochondrial dysfunction in adipocytes.","volume":"958","author":"Zhu","year":"2025","journal-title":"Sci Total Environ"},{"key":"B128","doi-asserted-by":"publisher","first-page":"109428","DOI":"10.1016\/j.envint.2025.109428","article-title":"Triphenyl phosphate induces lipid metabolism disorder and promotes obesity through PI3K\/AKT signaling pathway.","volume":"198","author":"Li","year":"2025","journal-title":"Environ Int"},{"key":"B129","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/s13578-025-01399-6","article-title":"Disrupting lipid homeostasis with CAV2 in OSCC triggers apoptosis, lipolysis, and mitochondrial dysfunction by transcriptional repression of PPAR\u03b3.","volume":"15","author":"Bai","year":"2025","journal-title":"Cell Biosci"},{"key":"B130","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.3390\/cells13171495","article-title":"The Tumor Suppressor Par-4 regulates adipogenesis by transcriptional repression of PPAR\u03b3.","volume":"13","author":"Sledziona","year":"2024","journal-title":"Cells"},{"key":"B131","doi-asserted-by":"publisher","first-page":"146449","DOI":"10.1016\/j.ijbiomac.2025.146449","article-title":"Okra polysaccharide activates PPAR-\u03b3 signaling to attenuate metabolic-associated fatty liver disease in mice.","volume":"321","author":"Cai","year":"2025","journal-title":"Int J Biol Macromol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s12951-025-03225-0","article-title":"Specific muscle targeted delivery of miR-130a loaded lipid nanoparticles: a novel approach to inhibit lipid accumulation in skeletal muscle and obesity.","volume":"23","author":"Wang","year":"2025","journal-title":"J Nanobiotechnology"},{"key":"B133","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.neuro.2025.07.003","article-title":"The role of nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-\u03b3) and Nrf2 signalling in methanol-induced on brain, eye, and pancreas toxicity in rats.","volume":"110","author":"Rezk","year":"2025","journal-title":"Neurotoxicology"},{"key":"B134","doi-asserted-by":"publisher","first-page":"1145467","DOI":"10.3389\/fendo.2023.1145467","article-title":"Osteocytes contribute via nuclear receptor PPAR-alpha to maintenance of bone and systemic energy metabolism.","volume":"14","author":"Chougule","year":"2023","journal-title":"Front Endocrinol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s11064-025-04422-x","article-title":"Protective effect of FABP5 against 6-OHDA induced Parkinson\u2019s Disease Via PPAR\u03b3\/SIRT1\/PGC-1\u03b1 signaling pathway.","volume":"50","author":"Ni","year":"2025","journal-title":"Neurochem Res"},{"key":"B136","doi-asserted-by":"publisher","first-page":"110103","DOI":"10.1016\/j.abb.2024.110103","article-title":"Protective effect of dimethyl fumarate against ethanol-provoked gastric ulcers in rats via regulation of HMGB1\/TLR4\/NF-\u03baB, and PPAR\u03b3\/SIRT1\/Nrf2 pathways: involvement of miR-34a-5p.","volume":"759","author":"Elbaz","year":"2024","journal-title":"Arch Biochem Biophys"},{"key":"B137","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1186\/s13046-024-03154-0","article-title":"Palmitoyltransferase ZDHHC6 promotes colon tumorigenesis by targeting PPAR\u03b3-driven lipid biosynthesis via regulating lipidome metabolic reprogramming.","volume":"43","author":"Shan","year":"2024","journal-title":"J Exp Clin Cancer Res."},{"key":"B138","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1093\/bbb\/zbae094","article-title":"Anti-inflammatory effect of covalent PPAR\u03b3 ligands that have a hybrid structure of GW9662 and a food-derived cinnamic acid derivative.","volume":"88","author":"Miyazawa","year":"2024","journal-title":"Biosci Biotechnol Biochem"},{"key":"B139","doi-asserted-by":"publisher","first-page":"2423843","DOI":"10.1080\/0886022X.2024.2423843","article-title":"Lycopene alleviates 5-fluorouracil-induced nephrotoxicity by modulating PPAR-\u03b3, Nrf2\/HO-1, and NF-\u03baB\/TNF-\u03b1\/IL-6 signals.","volume":"46","author":"Albadrani","year":"2024","journal-title":"Ren Fail."},{"key":"B140","doi-asserted-by":"publisher","first-page":"e41949","DOI":"10.1016\/j.heliyon.2025.e41949","article-title":"Modulation of adiposity and adipocyte inflammation by methanol extracts of Alpinia calcarata leaf in high-fat-diet induced-obese mice: involvement of COX-2 and PPAR-\u03b3.","volume":"11","author":"Ahmad","year":"2025","journal-title":"Heliyon"},{"key":"B141","doi-asserted-by":"publisher","first-page":"3804","DOI":"10.3390\/ijms26083804","article-title":"Luteolin relieves metabolic dysfunction-associated fatty liver disease caused by a high-fat diet in rats through modulating the AdipoR1\/AMPK\/PPAR\u03b3 signaling pathway.","volume":"26","author":"Taweesap","year":"2025","journal-title":"Int J Mol Sci."},{"key":"B142","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1089\/ars.2024.0670","article-title":"ALOX15 aggravates metabolic dysfunction-associated steatotic liver disease in mice with type 2 diabetes via activating the PPAR\u03b3\/CD36 axis.","volume":"43","author":"Yan","year":"2025","journal-title":"Antioxid Redox Signal"},{"key":"B143","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3390\/biomedicines13010010","article-title":"Metabolic activity in human intermuscular adipose tissue directs the response of resident PPAR\u03b3(+) macrophages to fatty acids.","volume":"13","author":"Chen","year":"2024","journal-title":"Biomedicines."},{"key":"B144","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s10822-025-00625-0","article-title":"Therapeutic potency of a developed optimized polyherbal formulation in ameliorating obesity induced inflammation and oxidative stress in Swiss albino mice by targeting PPAR\u03b3, insulin receptor and AMPK signalling pathway.","volume":"39","author":"Das","year":"2025","journal-title":"J Comput Aided Mol Des"},{"key":"B145","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1007\/978-3-031-63657-8_17","article-title":"Endothelial dysfunction in obesity and therapeutic targets.","volume":"1460","author":"Engin","year":"2024","journal-title":"Adv Exp Med Biol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1159\/000536093","article-title":"Helpful to live healthier? intermittent hypoxic\/ischemic training benefits vascular homeostasis and lipid metabolism with activating sirt1 pathways in overweight\/obese individuals.","volume":"17","author":"Jiao","year":"2024","journal-title":"Obes Facts"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1101\/2024.03.04.583402","article-title":"Cell-state dependent regulation of PPAR (\u03b3) signaling by ZBTB9 in adipocytes.","author":"Xu","year":"2024","journal-title":"bioRxiv"},{"key":"B148","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1186\/s12882-024-03859-6","article-title":"The impact of PPAR\u03b3 and ApoE gene polymorphisms on susceptibility to diabetic kidney disease in type 2 diabetes mellitus: a meta-analysis.","volume":"25","author":"Taurbekova","year":"2024","journal-title":"BMC Nephrol"},{"key":"B149","doi-asserted-by":"publisher","first-page":"2391511","DOI":"10.1080\/21623945.2024.2391511","article-title":"Decoding temporal thermogenesis: coregulator selectivity and transcriptional control in brown and beige adipocytes.","volume":"13","author":"Jeon","year":"2024","journal-title":"Adipocyte."},{"key":"B150","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1038\/s41467-024-45270-7","article-title":"Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates.","volume":"15","author":"Jeon","year":"2024","journal-title":"Nat Commun"},{"key":"B151","doi-asserted-by":"publisher","first-page":"102054","DOI":"10.1016\/j.molmet.2024.102054","article-title":"TGF-\u03b2 antagonism synergizes with PPAR\u03b3 agonism to reduce fibrosis and enhance beige adipogenesis.","volume":"90","author":"Bahn","year":"2024","journal-title":"Mol Metab"},{"key":"B152","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1111\/liv.15005","article-title":"PPAR-\u03b3-induced changes in visceral fat and adiponectin levels are associated with improvement of steatohepatitis in patients with NASH.","volume":"41","author":"Gastaldelli","year":"2021","journal-title":"Liver Int."},{"key":"B153","article-title":"Gut-derived PPAR-\u03b3 signaling and risk of bacterial enteric infection: insight from thiazolidinedione users in a US population-based study.","author":"Birabaharan","year":"2024","journal-title":"medRxiv"},{"key":"B154","doi-asserted-by":"crossref","first-page":"107765","DOI":"10.1016\/j.jbc.2024.107765","article-title":"PPAR\u03b3 and C\/EBP\u03b1 enable adipocyte differentiation upon inhibition of histone methyltransferase PRC2 in malignant tumors.","volume":"300","author":"Zhao","year":"2024","journal-title":"J Biol Chem."},{"key":"B155","doi-asserted-by":"publisher","first-page":"3305","DOI":"10.1007\/s11030-025-11118-5","article-title":"PPAR\u03b3 modulator predictor (PGMP_v1): chemical space exploration and computational insights for enhanced type 2 diabetes mellitus management.","volume":"29","author":"Amin","year":"2025","journal-title":"Mol Divers"},{"key":"B156","doi-asserted-by":"publisher","first-page":"156357","DOI":"10.1016\/j.metabol.2025.156357","article-title":"Lactiplantibacillus plantarum strain 84-3-derived l-glutamine ameliorates glucose homeostasis via AMPK\/PPAR\u03b3 signaling pathway activation in type 2 diabetes.","volume":"172","author":"Liang","year":"2025","journal-title":"Metabolism."},{"key":"B157","doi-asserted-by":"publisher","first-page":"157003","DOI":"10.1016\/j.phymed.2025.157003","article-title":"Selective PPAR\u03b3 modulator alpinetin restores insulin sensitivity and protects from bone loss in type 2 diabetes.","volume":"145","author":"Zhao","year":"2025","journal-title":"Phytomedicine"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.3724\/abbs.2025153","article-title":"Mitochondrial dysfunction in adipocyte differentiation: implications for obesity and metabolic syndrome intervention.","author":"Xu","year":"2025","journal-title":"Acta Biochim Biophys Sin."},{"key":"B159","doi-asserted-by":"publisher","first-page":"100772","DOI":"10.1016\/j.jlr.2025.100772","article-title":"SDCCAG3 inhibits adipocyte hypertrophy and improves obesity-related metabolic disorders via SDCCAG3\/SMURF1\/PPAR\u03b3 axis.","volume":"66","author":"Huo","year":"2025","journal-title":"J Lipid Res"},{"key":"B160","doi-asserted-by":"publisher","first-page":"112735","DOI":"10.1016\/j.nut.2025.112735","article-title":"Probiotic Lactiplantibacillus plantarum Lb41 alleviates high-fat diet-induced nonalcoholic fatty liver disease in mice.","volume":"134","author":"Lee","year":"2025","journal-title":"Nutrition."},{"key":"B161","doi-asserted-by":"publisher","first-page":"110018","DOI":"10.1016\/j.jnutbio.2025.110018","article-title":"Calycosin-7-O-\u03b2-D-glucoside alleviates nonalcoholic fatty liver disease by regulating short-chain fatty acids metabolism and metabolic regulators.","volume":"145","author":"Zeng","year":"2025","journal-title":"J Nutr Biochem"},{"key":"B162","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ajpath.2024.10.006","article-title":"Peroxisome proliferator-activated receptor \u03b1\/\u03b3 and cannabinoid receptor 2 agonist attenuated nonalcoholic steatohepatitis exosome-related abnormalities in mice.","volume":"195","author":"Huang","year":"2025","journal-title":"Am J Pathol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/s11658-025-00822-7","article-title":"CDK5 regulates PPAR\u03b3\/NF-\u03baB signaling to exacerbate obesity-related osteoarthritis via modulating macrophage polarization and chondrocyte apoptosis.","volume":"30","author":"Li","year":"2025","journal-title":"Cell Mol Biol Lett"},{"key":"B164","doi-asserted-by":"publisher","first-page":"1579445","DOI":"10.3389\/fchem.2025.1579445","article-title":"Discovery of a novel binding pocket in PPAR\u03b3 for partial agonists: structure-based virtual screening identifies ginsenoside Rg5 as a partial agonist promoting beige adipogenesis.","volume":"13","author":"Wang","year":"2025","journal-title":"Front Chem."},{"key":"B165","doi-asserted-by":"publisher","first-page":"4709","DOI":"10.1111\/dom.16508","article-title":"Indirect comparative efficacy and safety of tirzepatide 10 and 15 mg versus semaglutide 2.4 mg for the management of obesity and overweight in patients with type 2 diabetes.","volume":"27","author":"Ciudin","year":"2025","journal-title":"Diabetes Obes Metab"},{"key":"B166","doi-asserted-by":"publisher","first-page":"4268","DOI":"10.1111\/dom.16463","article-title":"Tirzepatide and health-related quality of life in adults with obesity or overweight: results from the SURMOUNT-3 phase 3 randomized trial.","volume":"27","author":"Gibble","year":"2025","journal-title":"Diabetes Obes Metab."},{"key":"B167","doi-asserted-by":"publisher","first-page":"24103","DOI":"10.1038\/s41598-025-09807-0","article-title":"Efficacy and safety of GLP-1 agonists in the treatment of T2DM: a systematic review and network meta-analysis.","volume":"15","author":"Ren","year":"2025","journal-title":"Sci Rep"},{"key":"B168","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1038\/s44321-025-00216-4","article-title":"Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity.","volume":"17","author":"Chang","year":"2025","journal-title":"EMBO Mol Med"},{"key":"B169","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1080\/19390211.2025.2480582","article-title":"Damiana (Turnera diffusa) Reduces Adipocyte Cell Differentiation and Ameliorates Myocyte Glucose Uptake.","volume":"22","author":"Chae","year":"2025","journal-title":"J Diet Suppl"},{"key":"B170","doi-asserted-by":"publisher","first-page":"853","DOI":"10.3390\/ijms26020853","article-title":"Aspirin Inhibits the In Vitro Adipogenic Differentiation of Human Adipose Tissue-Derived Stem Cells in a Dose-Dependent Manner.","volume":"26","author":"Funke","year":"2025","journal-title":"Int J Mol Sci"},{"key":"B171","doi-asserted-by":"publisher","first-page":"118615","DOI":"10.1016\/j.biopha.2025.118615","article-title":"Structure-based discovery of a novel nuclear receptor PPAR\u03b3 inhibitor: implications for obesity and metabolic disease intervention.","volume":"192","author":"Tachachartvanich","year":"2025","journal-title":"Biomed Pharmacother"},{"key":"B172","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1097\/MCA.0000000000001554","article-title":"Sophoricoside enhances reparative macrophage polarization to promote cardiac repair postmyocardial infarction through PPAR-\u03b3.","volume":"37","author":"Xu","year":"2026","journal-title":"Coron Artery Dis"},{"key":"B173","doi-asserted-by":"publisher","first-page":"115165","DOI":"10.1016\/j.intimp.2025.115165","article-title":"Component characterization of Zanthoxylum nitidum extract and its anti-colitis effect through regulating PPAR\u03b3\/NF-\u03baB\/iNOS signaling pathway and gut microbiota.","volume":"162","author":"Lu","year":"2025","journal-title":"Int Immunopharmacol"},{"key":"B174","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1080\/07391102.2023.2283161","article-title":"Rational design of thiazolidine-4-one-gallic acid hybrid derivatives as selective partial PPAR\u03b3 modulators: an in-silico approach for type 2 diabetes treatment.","volume":"43","author":"Aryan, Babu","year":"2025","journal-title":"J Biomol Struct Dyn."},{"key":"B175","doi-asserted-by":"publisher","first-page":"123327","DOI":"10.1016\/j.lfs.2024.123327","article-title":"The ameliorating effect of intermittent fasting on intestinal glucagon-like peptide 1 in rats fed a high-fat diet via the Farnesoid X receptor and the Melanocortin-4 receptor.","volume":"361","author":"Eraky","year":"2025","journal-title":"Life Sci."},{"key":"B176","doi-asserted-by":"publisher","first-page":"177272","DOI":"10.1016\/j.ejphar.2025.177272","article-title":"Role of 11\u03b2-hydroxysteroid dehydrogenase type 1 inhibition in the antiobesity effect of J2H-1702 on adipocytes and a high-fat diet-induced NASH model.","volume":"989","author":"Lee","year":"2025","journal-title":"Eur J Pharmacol"},{"key":"B177","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.3390\/antiox12081523","article-title":"Functional and structural insights into the human PPAR\u03b1\/\u03b4\/\u03b3 targeting preferences of anti-NASH investigational drugs, lanifibranor, seladelpar, and elafibranor.","volume":"12","author":"Kamata","year":"2023","journal-title":"Antioxidants."},{"key":"B178","doi-asserted-by":"publisher","first-page":"e13484","DOI":"10.1111\/1753-0407.13484","article-title":"Impact of chiglitazar on glycemic control in type 2 diabetic patients with metabolic syndrome and insulin resistance: a pooled data analysis from two phase III trials.","volume":"16","author":"Ning","year":"2024","journal-title":"J Diabetes"},{"key":"B179","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.3390\/biom13081264","article-title":"Current clinical trial status and future prospects of PPAR-targeted drugs for treating nonalcoholic fatty liver disease.","volume":"13","author":"Kamata","year":"2023","journal-title":"Biomolecules."},{"key":"B180","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.2147\/DDDT.S302215","article-title":"No relevant pharmacokinetic drug-drug interaction between the sodium-glucose co-transporter-2 inhibitor empagliflozin and lobeglitazone, a peroxisome proliferator-activated receptor-\u03b3 agonist, in healthy subjects.","volume":"15","author":"Kim","year":"2021","journal-title":"Drug Des Devel Ther."},{"key":"B181","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1016\/j.jhep.2023.02.004","article-title":"Evaluation of PXL065 - deuterium-stabilized (R)-pioglitazone in patients with NASH: a phase II randomized placebo-controlled trial (DESTINY-1).","volume":"78","author":"Harrison","year":"2023","journal-title":"J Hepatol"},{"key":"B182","doi-asserted-by":"publisher","first-page":"1695785","DOI":"10.3389\/fphar.2025.1695785","article-title":"EGCG alleviates PM2.5-induced lung injury via activation of PPAR-\u03b3 to suppress inflammation and oxidative stress.","volume":"16","author":"Liu","year":"2025","journal-title":"Front Pharmacol."},{"key":"B183","doi-asserted-by":"publisher","first-page":"11164","DOI":"10.1007\/s12035-025-04899-1","article-title":"Silencing Hmox1 attenuates cerebral ischemia\/reperfusion injury and inhibits inflammation and ferroptosis Via the PPAR-\u03b3\/FABP4 signaling pathway.","volume":"62","author":"Li","year":"2025","journal-title":"Mol Neurobiol"},{"key":"B184","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1080\/08923973.2025.2517634","article-title":"Anti-inflammatory and immunomodulatory effects of valproate and carbamazepine involve distinct signaling in human peripheral blood mononuclear cells.","volume":"47","author":"Popovi\u0107","year":"2025","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"B185","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1021\/acs.jmedchem.2c02002","article-title":"Correction to \u201cdiscovery and structure-based design of potent covalent PPAR\u03b3 inverse-agonists BAY-4931 and BAY-0069\u201d.","volume":"66","author":"Orsi","year":"2023","journal-title":"J Med Chem."},{"key":"B186","doi-asserted-by":"publisher","first-page":"17587","DOI":"10.1021\/acs.jmedchem.5c01252","article-title":"Structural Basis of PPAR\u03b3-mediated transcriptional repression by the covalent inverse agonist FX-909.","volume":"68","author":"Laughlin","year":"2025","journal-title":"J Med Chem"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1101\/2025.05.04.651770","article-title":"Structural basis of PPAR\u03b3-mediated transcriptional repression by the covalent inverse agonist FX-909.","author":"Laughlin","year":"2025","journal-title":"bioRxiv"},{"key":"B188","doi-asserted-by":"publisher","first-page":"149998","DOI":"10.1016\/j.bbrc.2024.149998","article-title":"Deletion of Impdh2 in adipocyte precursors limits the expansion of white adipose tissue and enhances metabolic health with overnutrition.","volume":"716","author":"Hu","year":"2024","journal-title":"Biochem Biophys Res Commun"},{"key":"B189","doi-asserted-by":"publisher","first-page":"e70061","DOI":"10.1002\/edm2.70061","article-title":"Efficacy and safety of pioglitazone add-on in patients with type 2 diabetes mellitus inadequately controlled with metformin and dapagliflozin: a systematic review and meta-analysis of randomised controlled trials.","volume":"8","author":"Khan","year":"2025","journal-title":"Endocrinol Diabetes Metab."},{"key":"B190","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1186\/s13098-025-01823-4","article-title":"Seagrass Enhalus acoroides extract mitigates obesity and diabetes via GLP-1, PPAR\u03b3, SREBP-1c modulation and gut microbiome restoration in diabetic zebrafish.","volume":"17","author":"Kadharusman","year":"2025","journal-title":"Diabetol Metab Syndr"},{"key":"B191","doi-asserted-by":"publisher","first-page":"e0330683","DOI":"10.1371\/journal.pone.0330683","article-title":"Effects of boysenberry on postprandial energy metabolism in healthy adults: a randomized controlled crossover trial.","volume":"20","author":"Furuuchi","year":"2025","journal-title":"PLoS One."},{"key":"B192","doi-asserted-by":"publisher","first-page":"177651","DOI":"10.1016\/j.ejphar.2025.177651","article-title":"Rethinking fat Browning: uncovering new molecular insights into the synergistic roles of fasting, exercise, and cold exposure.","volume":"998","author":"Asghari Alashti","year":"2025","journal-title":"Eur J Pharmacol"},{"key":"B193","doi-asserted-by":"publisher","first-page":"123463","DOI":"10.1016\/j.biomaterials.2025.123463","article-title":"In vivo brown adipogenic reprogramming induced by a small molecule cocktail.","volume":"324","author":"Kannappan","year":"2026","journal-title":"Biomaterials"},{"key":"B194","doi-asserted-by":"publisher","first-page":"e70035","DOI":"10.1002\/biof.70035","article-title":"Fucosterol promotes browning in mouse 3T3-L1 adipocytes through HO-1\/Nrf2 and AMPK pathways.","volume":"51","author":"Suryaningtyas","year":"2025","journal-title":"Biofactors"},{"key":"B195","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1007\/s13105-025-01117-3","article-title":"The multifaceted regulation of white adipose tissue browning and their therapeutic potential.","volume":"81","author":"Satheesan","year":"2025","journal-title":"J Physiol Biochem"},{"key":"B196","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/jocd.16002","article-title":"Innovation of the protocol for the application of cryolipolysis: effects and mechanisms of action.","volume":"23","author":"Palauro","year":"2024","journal-title":"J Cosmet Dermatol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1002\/lsm.23839","article-title":"Effects of cryolipolysis on the conversion of white adipose tissue: pilot study.","volume":"57","author":"Palauro","year":"2025","journal-title":"Lasers Surg Med."},{"key":"B198","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1007\/s10616-025-00790-y","article-title":"Falcarindiol promotes beige adipocyte-related gene expression and mitochondrial respiration in human preadipocyte-derived adipocytes.","volume":"77","author":"Takahashi","year":"2025","journal-title":"Cytotechnology"},{"key":"B199","doi-asserted-by":"publisher","first-page":"553","DOI":"10.13702\/j.1000-0607.20240755","article-title":"[Electroacupuncture activates PKA \/ CREB signaling pathway to promote browning of white fat in obese rats].","volume":"50","author":"Liao","year":"2025","journal-title":"Zhen Ci Yan Jiu."},{"key":"B200","doi-asserted-by":"publisher","first-page":"116757","DOI":"10.1016\/j.bcp.2025.116757","article-title":"Enhanced thermogenesis in PAS Kinase-deficient male mice.","volume":"233","author":"Hurtado-Carneiro","year":"2025","journal-title":"Biochem Pharmacol"},{"key":"B201","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.clnu.2025.05.005","article-title":"Effects of multi-strain probiotics supplementation on body adiposity and metabolic profile in individuals with hypertension and overweight following an energy-restricted diet: a randomized clinical trial.","volume":"50","author":"Pontes","year":"2025","journal-title":"Clin Nutr."},{"key":"B202","doi-asserted-by":"publisher","first-page":"CD015875","DOI":"10.1002\/14651858.CD015875","article-title":"Gut microbiome-based interventions for the management of obesity in children and adolescents aged up to 19 years.","volume":"7","author":"Fahim","year":"2025","journal-title":"Cochrane Database Syst Rev"},{"key":"B203","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1163\/18762891-bja00080","article-title":"Synergistic effects of human-origin novel postbiotic Bacteroides & Phocaeicola on obesity and thermogenesis in high-fat diet-induced metabolic dysfunction.","volume":"17","author":"Wu","year":"2025","journal-title":"Benef Microbes."},{"key":"B204","doi-asserted-by":"publisher","first-page":"867","DOI":"10.3390\/foods14050867","article-title":"Lactobacillus fermentum 166, derived from yak yogurt from tibetan areas of sichuan, improves high-fat-diet-induced hyperlipidemia by modulating gut microbiota and liver- and gut-related pathways.","volume":"14","author":"Zhang","year":"2025","journal-title":"Foods"},{"key":"B205","doi-asserted-by":"publisher","first-page":"109708","DOI":"10.1016\/j.jnutbio.2024.109708","article-title":"The attenuation of gut microbiota-derived short-chain fatty acids elevates lipid transportation through suppression of the intestinal HDAC3-H3K27ac-PPAR-\u03b3 axis in gestational diabetes mellitus.","volume":"133","author":"Chen","year":"2024","journal-title":"J Nutr Biochem."},{"key":"B206","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1007\/s00394-024-03520-w","article-title":"The probiotic Lactobacillus plantarum alleviates colitis by modulating gut microflora to activate PPAR\u03b3 and inhibit MAPKs\/NF-\u03baB.","volume":"64","author":"Zang","year":"2024","journal-title":"Eur J Nutr"},{"key":"B207","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.clnesp.2025.03.049","article-title":"The role of micro-ribonucleic acid and small interfering-ribonucleic acid in precision nutrition for obesity management.","volume":"67","author":"Humayrah","year":"2025","journal-title":"Clin Nutr ESPEN."},{"key":"B208","doi-asserted-by":"publisher","first-page":"123417","DOI":"10.1016\/j.lfs.2025.123417","article-title":"Hyperoside mitigates PCOS-associated adipogenesis and insulin resistance by regulating NCOA2-mediated PPAR-\u03b3 ubiquitination and degradation.","volume":"364","author":"Zhou","year":"2025","journal-title":"Life Sci"},{"key":"B209","doi-asserted-by":"publisher","first-page":"156097","DOI":"10.1016\/j.metabol.2024.156097","article-title":"Recent advances and therapeutic applications of PPAR\u03b3-targeted ligands based on the inhibition mechanism of Ser273 phosphorylation.","volume":"163","author":"Chen","year":"2025","journal-title":"Metabolism."},{"key":"B210","doi-asserted-by":"publisher","first-page":"1805447","DOI":"10.3389\/fpsyt.2026.1805447","article-title":"Correction: gender differences in gut microbiome composition between schizophrenia patients with normal body weight and central obesity.","volume":"17","author":"Tsai","year":"2026","journal-title":"Front Psychiatry"},{"key":"B211","doi-asserted-by":"publisher","first-page":"L267","DOI":"10.1152\/ajplung.00400.2025","article-title":"Ovarian hormones and obesity drive Th17-mediated airway inflammation through estrogen receptor-\u03b1 signaling.","volume":"330","author":"Henriquez Pilier","year":"2026","journal-title":"Am J Physiol Lung Cell Mol Physiol."}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1820776\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T06:18:00Z","timestamp":1779949080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1820776\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":211,"alternative-id":["10.3389\/fnut.2026.1820776"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1820776","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]},"article-number":"1820776"}}