{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T05:11:48Z","timestamp":1778735508013,"version":"3.51.4"},"reference-count":63,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:00:00Z","timestamp":1778716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Female distance runners are at elevated risk for impaired bone remodeling due to high mechanical loading, potential low energy availability, and sustained inflammatory stress. Collagen peptide (CP) supplementation has been proposed as a nutritional strategy to support type I collagen synthesis and modulate osteoimmune signaling; however, evidence in premenopausal endurance athletes is limited. This pilot randomized, double-blind, placebo-controlled trial examined the effects of four weeks of high-dose CP supplementation on markers of bone metabolism and inflammatory activity in endurance-trained premenopausal women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty-two participants (18\u201335 years; \u226535 miles\/week [&amp;gt;56km\/week]) were randomized to CP (INT; 20 g\/day) or isocaloric maltodextrin (CON). Pre- and post-intervention assessments, conducted in the early follicular phase, included serum procollagen type I N-terminal propeptide (P1NP), plasma C-terminal telopeptide of type I collagen (CTX-1), serum soluble receptor activator of nuclear factor-\u03baB ligand (sRANKL), osteoprotegerin (OPG), the sRANKL\/OPG ratio, and interleukin-6 (IL-6). Repeated-measures ANCOVAs were performed, adjusting for accumulated running distance and vitamin D status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A significant group \u00d7 time interaction was observed for P1NP (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.04), with increases in INT and no change in CON. No significant interaction was observed for CTX-1 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.13). Significant interactions were also observed for sRANKL (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.046) and IL-6 (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). No significant interaction effects were detected for sRANKL, OPG, or the sRANKL\/OPG ratio.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Short-term CP supplementation increased a marker of bone formation, altered osteoclast-related signaling, and reduced IL-6 in endurance-trained premenopausal women. These findings support the potential for CP-mediated modulation of bone turnover and inflammatory activity and warrant further investigation in larger, adequately powered trials incorporating structural bone outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1825906","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:30:17Z","timestamp":1778733017000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of collagen peptide supplementation on bone turnover, cytokine, and inflammatory markers in female distance runners: a randomized pilot study"],"prefix":"10.3389","volume":"13","author":[{"given":"Nicholas M.","family":"Kuhlman","sequence":"first","affiliation":[{"name":"Exercise and Sport Science Department, Fitchburg State University","place":["Fitchburg, MA, United States"]},{"name":"Department of Nutritional Sciences, University of Connecticut","place":["Storrs, CT, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew R.","family":"Jagim","sequence":"additional","affiliation":[{"name":"Sports Medicine Department, Mayo Clinic Health System","place":["La Crosse, WI, United States"]},{"name":"Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University","place":["Fairfax, VA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher N.","family":"Blesso","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut","place":["Storrs, CT, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Puglisi","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut","place":["Storrs, CT, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ock K.","family":"Chun","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut","place":["Storrs, CT, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret T.","family":"Jones","sequence":"additional","affiliation":[{"name":"Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University","place":["Fairfax, VA, United States"]},{"name":"Sport, Recreation, and Tourism Management, George Mason University","place":["Fairfax, VA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer B.","family":"Fields","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences, University of Connecticut","place":["Storrs, CT, United States"]},{"name":"Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University","place":["Fairfax, VA, United 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