{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T03:31:59Z","timestamp":1793417519708,"version":"4.5.0"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background and aims<\/jats:title>\n                    <jats:p>This pilot randomized controlled-feeding trial compared the effect of Specific Carbohydrate Diet (SCD) and Mediterranean diet (MeD) in mild to moderate ulcerative colitis (UC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Seventeen adults were randomized to a 6-week SCD (\n                      <jats:italic>n<\/jats:italic>\n                      =\u202f8) or MeD (\n                      <jats:italic>n<\/jats:italic>\n                      =\u202f9) intervention. Primary outcome was change in partial Mayo Clinic score (pMCS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study was discontinued early due to significant dropout (\n                      <jats:italic>n<\/jats:italic>\n                      =\u202f9, 52.9%). There was no significant between-group differences observed for pMCS change (SCD, \u22120.8; MeD, \u22121.3;\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.499) or secondary outcomes. Exploratory metagenomic analysis revealed enrichment of\n                      <jats:italic>Parasutterella excrementihominis<\/jats:italic>\n                      in SCD at week 10.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this pilot trial, SCD and MeD showed no difference in therapeutic effects for patients with mild to moderate UC. However, the study was limited by a significant drop out in both arms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>ClinicalTrials.gov<\/jats:ext-link>\n                      , identifier NCT04398550.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1838160","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T04:25:54Z","timestamp":1783657554000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Specific carbohydrate diet versus Mediterranean diet in adult patients with mild to moderate ulcerative colitis: a randomized controlled-feeding trial"],"prefix":"10.3389","volume":"13","author":[{"given":"Albert Sheng-Yin","family":"Chen","sequence":"first","affiliation":[{"name":"Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School","place":["Boston, MA, United States"]},{"name":"Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long H.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School","place":["Boston, MA, United States"]},{"name":"Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna","family":"Gray","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Centers, Massachusetts General Hospital","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Williams","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Gurung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Canha","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School","place":["Boston, MA, United States"]},{"name":"Sidney Kimmel Medical College, Thomas Jefferson University","place":["Philadelphia, PA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"McGoldrick","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Hubbard","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Centers, Massachusetts General Hospital","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Khalili","sequence":"additional","affiliation":[{"name":"Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School","place":["Boston, MA, United States"]},{"name":"Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School","place":["Boston, MA, United States"]},{"name":"Broad Institute of MIT and 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