{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T15:00:32Z","timestamp":1785510032074,"version":"3.56.0"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the efficacy and safety of an \u201coral simulated tube feeding method\u201d compared to nasogastric feeding in patients with moderately severe acute pancreatitis (MSAP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this randomized controlled non-inferiority trial, 60 MSAP patients were assigned to either the oral simulated tube feeding group (STREAM,\n                      <jats:italic>n<\/jats:italic>\n                      = 31) or the nasogastric group (NG,\n                      <jats:italic>n<\/jats:italic>\n                      = 29). The primary outcome was the 24-h enteral nutrition (EN) tolerance rate.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The 24-h tolerance rate in the STREAM group was non-inferior to the NG group (96.8% vs. 69.0%,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). Secondary outcomes showed the STREAM group had lower 24-h tolerance scores (1.94 \u00b1 0.26 vs. 3.59 \u00b1 0.34,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001) and fewer occurrences of abdominal distension (\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001) and nausea (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.025). Additionally, the STREAM group had significantly lower hospitalization costs (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.011), with only 12.9% of patients exceeding 10,000 \u00a5 compared to 48.3% in the NG group. No significant difference was observed in the length of hospital stay.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The oral simulated tube feeding method is a non-inferior, safe, and cost-effective alternative to nasogastric feeding for MSAP patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1838503","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:10:21Z","timestamp":1785507021000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Application of the \u201coral simulated tube feeding method\u201d in enteral nutrition for patients with moderately severe acute pancreatitis: a randomized controlled non-inferiority trial comparing the nasogastric feeding 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