{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:50:28Z","timestamp":1782301828452,"version":"3.54.5"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:00:00Z","timestamp":1782259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>With the acceleration of global population aging, maintaining healthy longevity in an aging society become an important concern. This study examined whether D-WP influences key factors of a healthy lifespan, such as \u03b1-Klotho, fibroblast growth factor-23 (FGF-23), and sirtuin 1 (SIRT1), in mice. Mice who received oral D-WP for 8\u202fdays exhibited significantly increased plasma \u03b1-Klotho concentrations. On the other hand, plasma concentrations of FGF-23 and SIRT1 were not changed by oral intake of D-WP. Moreover, kidney \u03b1-Klotho protein concentrations were also significantly increased by oral intake of D-WP for 8\u202fdays. Oral intake of intact whey protein did not induce the same effects as D-WP. These findings suggest that D-WP may have a potency to increase plasma Klotho levels.<\/jats:p>","DOI":"10.3389\/fnut.2026.1839336","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:07:07Z","timestamp":1782299227000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Degalactosylated whey protein increases \u03b1-Klotho concentrations in the plasma and kidney in mice"],"prefix":"10.3389","volume":"13","author":[{"given":"Toshio","family":"Inui","sequence":"first","affiliation":[{"name":"Saisei Pharma","place":["Moriguchi, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namiko","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences","place":["Kagoshima, Japan"]},{"name":"Department of Medicine and Bioregulatory Science, Graduate 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