{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:46:51Z","timestamp":1785732411424,"version":"3.56.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T00:00:00Z","timestamp":1785715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Young Elite Scientist Sponsorship Program by Cast","award":["YESS20220687"],"award-info":[{"award-number":["YESS20220687"]}]},{"name":"18th batch of Special Funding from the China Postdoctoral Science Foundation","award":["2025T180639"],"award-info":[{"award-number":["2025T180639"]}]},{"name":"Youth Science Foundation Project of Guangxi Medical University","award":["GXMUYSF202548"],"award-info":[{"award-number":["GXMUYSF202548"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aimed to investigate the association of baseline Nutritional-C-reactive Protein Ratio (NCR) with overall survival (OS), severe malnutrition, and cachexia in patients with gastric cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Baseline NCR was calculated as BMI (kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      )\u202f\u00d7\u202falbumin (g\/L) \/ C-reactive protein (mg\/L) using measurements obtained at study enrollment and original continuous CRP values. The ROC-derived cutoff was used to classify patients into low- and high-NCR groups. Kaplan\u2013Meier curves and log-rank tests were used to compare OS. Cox proportional hazards models assessed the association between NCR and OS, while logistic regression evaluated associations with severe malnutrition and cachexia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1,058 patients with pathologically confirmed gastric cancer were included. The exploratory ROC-derived cutoff value for NCR was 178. Patients with high NCR had significantly better OS than those with low NCR (65.3% vs. 48.4%, log-rank\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). In multivariable Cox regression, high NCR was independently associated with better OS (HR\u202f=\u202f0.598, 95% CI: 0.478\u20130.747,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), with a significant dose\u2013response relationship across NCR quartiles (p for trend &amp;lt; 0.001). Logistic regression showed that high NCR was associated with lower odds of severe malnutrition (OR\u202f=\u202f0.390, 95% CI: 0.300\u20130.505,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001) and cachexia (OR\u202f=\u202f0.182, 95% CI: 0.137\u20130.242,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Baseline NCR is a simple and clinically accessible composite biomarker integrating nutritional and inflammatory status. It may serve as a complementary marker for risk stratification in patients with gastric cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1840225","type":"journal-article","created":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T04:27:41Z","timestamp":1785731261000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Nutritional-C-reactive protein ratio as a prognostic marker in gastric cancer: a multicenter study"],"prefix":"10.3389","volume":"13","author":[{"given":"Yibo","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuquan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanping","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailun","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Gland Surgery, The First Affiliated Hospital, Guangxi Medical University","place":["Nanning, Guangxi, China"]},{"name":"Guangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer","place":["Nanning, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3322\/caac.21820","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/cac2.12025","article-title":"Cancer burden of major cancers in China: a need for sustainable actions","volume":"40","author":"Cao","year":"2020","journal-title":"Cancer 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