{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:00:13Z","timestamp":1780981213057,"version":"3.54.1"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The high burden of functional and chronic disability in older adults due to osteoporotic vertebral compression fractures (OVCFs) reflects both fracture characteristics and patient-related factors influencing recovery. The underlying conditions that define frailty and sarcopenia, or the inability of osteoporotic patients to maintain muscle mass, may have an important role in functional recovery after OVCF.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this retrospective cohort study, 120 patients aged \u226560 years who were diagnosed with radiologically confirmed OVCFs and underwent treatment in a tertiary care center from January 2020 to December 2023 were included. Patients were stratified based on sarcopenia and frailty. The primary outcome of interest was functional recovery, as measured by the Barthel Index at discharge; secondary outcomes included length of hospital stay, complications, VAS pain score, and hospital-based complications. Multivariable linear regression of functional recovery on the independent variables was then calculated. The primary endpoint reflects early in-hospital functional recovery and does not capture long-term outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared to non-frail patients, frail individuals had lower Barthel Index scores (65.3 \u00b1 12.4 vs. 82.5 \u00b1 10.2,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001), higher pain (5.1 \u00b1 1.5 vs. 3.8 \u00b1 1.2,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.02), longer length of stay (12.4 \u00b1 4.1 vs. 8.5 \u00b1 3.2 days,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.01), and higher complication rates (27.7% vs. 10.9%,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.03). Similar patterns were observed among patients with sarcopenia. Multivariable regression models showed that frailty (\u03b2 = \u221212.45,\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt; 0.001) and sarcopenia (\u03b2 = \u22128.32,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.004) were independently associated with reduced early functional recovery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Frailty and sarcopenia were independently associated with reduced early functional recovery in older adults with osteoporotic vertebral compression fractures. These findings highlight the potential importance of incorporating geriatric and muscle health assessments into clinical evaluation; however, further prospective studies are required to confirm these associations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1841245","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:34:23Z","timestamp":1780979663000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Frailty and sarcopenia as independent predictors of early functional recovery in older adults with osteoporotic vertebral compression fractures: a retrospective cohort study"],"prefix":"10.3389","volume":"13","author":[{"given":"Jinxian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital","place":["Taiyuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1007\/s11657-025-01588-3","article-title":"The 2024 UK clinical guideline for the prevention and treatment of osteoporosis","volume":"20","author":"Gregson","year":"2025","journal-title":"Arch Osteoporos"},{"key":"B2","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1001\/jama.2025.6003","article-title":"Osteoporosis: a review","volume":"334","author":"Morin","year":"2025","journal-title":"JAMA."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1007\/s00198-021-05900-y","article-title":"The clinician's guide to prevention and treatment of osteoporosis","volume":"33","author":"LeBoff","year":"2022","journal-title":"Osteoporos Int."},{"key":"B4","doi-asserted-by":"publisher","first-page":"934","DOI":"10.31616\/asj.2022.0441","article-title":"Management of osteoporotic vertebral fracture: review update 2022","volume":"16","author":"Jang","year":"2022","journal-title":"Asian Spine J."},{"key":"B5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1051\/sicotj\/2025035","article-title":"Osteoporotic vertebral fractures: an update","volume":"11","author":"Daskalakis","year":"2025","journal-title":"SICOT J."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1670","DOI":"10.1016\/j.spinee.2025.01.016","article-title":"3rd, Annaswamy TM, et al. Guideline summary review: an evidence-based clinical guideline for the diagnosis and treatment of adults with osteoporotic vertebral compression fractures","volume":"25","author":"Cho","year":"2025","journal-title":"Spine J"},{"key":"B7","doi-asserted-by":"publisher","first-page":"101851","DOI":"10.1016\/j.bonr.2025.101851","article-title":"East meets west action group of the european calcified tissue society. The prevention of osteoporotic vertebral fractures in eastern and in western countries","volume":"25","author":"Koromani","year":"2025","journal-title":"Bone Rep."},{"key":"B8","doi-asserted-by":"publisher","first-page":"101582","DOI":"10.1016\/j.regg.2024.101582","article-title":"Efficacy and safety of osteoporosis treatment in older adults. Approach for the secondary prevention of fractures in older populations. a proposal by SEFRAOS","volume":"60","author":"Cuadra-Llopart","year":"2025","journal-title":"Rev Esp Geriatr Gerontol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1007\/s00198-024-07052-1","article-title":"Effectiveness of fracture liaison service in reducing the risk of secondary fragility fractures in adults aged 50 and older: a systematic review and meta-analysis","volume":"35","author":"Danazumi","year":"2024","journal-title":"Osteoporos Int."},{"key":"B10","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s11657-025-01612-6","article-title":"Real-life effectiveness of a Fracture Liaison Service in reducing short-term mortality and second fractures after hip fracture: a five-year prospective study","volume":"20","author":"Gonz\u00e1lez-Quevedo","year":"2025","journal-title":"Arch Osteoporos."},{"key":"B11","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1007\/s11657-025-01521-8","article-title":"Primary care follow-up of patients after attending a fracture liaison service: an integrative review","volume":"20","author":"Bennett","year":"2025","journal-title":"Arch Osteoporos."},{"key":"B12","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.ecl.2024.08.008","article-title":"Postmenopausal osteoporosis: a review of latest guidelines","volume":"53","author":"Subarajan","year":"2024","journal-title":"Endocrinol Metab Clin North Am."},{"key":"B13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1093\/ejendo\/lvae080","article-title":"Predicting fragility fractures based on frailty and bone mineral density among rural community-dwelling older adults","volume":"191","author":"Lee","year":"2024","journal-title":"Eur J Endocrinol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"ziaf009","DOI":"10.1093\/jbmrpl\/ziaf009","article-title":"Frailty and osteoporotic fractures represent mutual risks for each other with common physiological backgrounds","volume":"9","author":"Urano","year":"2025","journal-title":"JBMR Plus"},{"key":"B15","doi-asserted-by":"publisher","first-page":"408","DOI":"10.52312\/jdrs.2025.2202","article-title":"Frailty as a predictor of vertebral fractures in osteoporosis: a clinical perspective","volume":"36","author":"Sahiner","year":"2025","journal-title":"Jt Dis Relat Surg."},{"key":"B16","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s11657-025-01633-1","article-title":"Sarcopenia in Patients with Osteoporotic Vertebral Fractures is associated with higher risk of multiple vertebral fractures","volume":"21","author":"Bekele","year":"2025","journal-title":"Arch Osteoporos."},{"key":"B17","doi-asserted-by":"publisher","first-page":"476","DOI":"10.31616\/asj.2024.0467","article-title":"Impact of sarcopenia on outcomes following vertebral augmentation for osteoporotic vertebral compression fracture: a systematic review and meta-analysis","volume":"19","author":"Nguyen","year":"2025","journal-title":"Asian Spine J."},{"key":"B18","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.2147\/CIA.S532935","article-title":"The relation of osteoporotic vertebral fractures and sarcopenic characteristics on the occurrence of complications: a systematic review","volume":"20","author":"Roschke","year":"2025","journal-title":"Clin Interv Aging."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000546501","article-title":"Sarcopenia and osteoporosis","volume":"19","author":"Mocini","year":"2025","journal-title":"Gerontology."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1577758","DOI":"10.3389\/fendo.2025.1577758","article-title":"Osteosarcopenia: epidemiology, molecular mechanisms, and management","volume":"16","author":"Yi","year":"2025","journal-title":"Front Endocrinol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s40520-025-03229-8","article-title":"Osteosarcopenia as a risk factor for fractures and mortality - 19-year follow-up of a population-based sample","volume":"37","author":"Blomqvist","year":"2025","journal-title":"Aging Clin Exp Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1097\/MCO.0000000000001118","article-title":"The potential of creatine monohydrate supplementation in the management of osteosarcopenia","volume":"28","author":"Candow","year":"2025","journal-title":"Curr Opin Clin Nutr Metab Care."},{"key":"B23","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1007\/s11657-025-01573-w","article-title":"Association of sarcopenic obesity and osteoporosis in postmenopausal women: risk factors and protective effects of hormonal therapy and nutritional status","volume":"20","author":"Chucherd","year":"2025","journal-title":"Arch Osteoporos."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1111\/jgs.19292","article-title":"A scoping review of hospital-based geriatric-centered interventions on trauma surgery services","volume":"73","author":"Dhanani","year":"2025","journal-title":"J Am Geriatr Soc."},{"key":"B25","doi-asserted-by":"publisher","first-page":"afac104","DOI":"10.1093\/ageing\/afac104","article-title":"Comprehensive geriatric assessment in older people: an umbrella review of health outcomes","volume":"51","author":"Veronese","year":"2022","journal-title":"Age Ageing"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1186\/s12877-025-06667-1","article-title":"Exploring the experience and needs of postoperative rehabilitation management for elderly patients with osteoporotic vertebral compression fractures after percutaneous vertebroplasty: a qualitative study","volume":"25","author":"Kang","year":"2025","journal-title":"BMC Geriatr."},{"key":"B27","doi-asserted-by":"publisher","first-page":"101430","DOI":"10.1016\/j.physio.2024.101430","article-title":"Development and implementation of a physiotherapy exercise intervention with tailored support for exercise adherence for people with vertebral fragility fractures (OPTIN trial)","volume":"126","author":"Newman","year":"2025","journal-title":"Physiotherapy."},{"key":"B28","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s40814-025-01665-x","article-title":"Virtual Intervention for Vertebral frActures (VIVA): protocol for a feasibility study of a multicentre randomized controlled trial","volume":"11","author":"Sevinc","year":"2025","journal-title":"Pilot Feasibility Stud."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1532355","DOI":"10.3389\/fendo.2025.1532355","article-title":"Association between thoracolumbar fascia injury and residual back pain following percutaneous vertebral augmentation: a systematic review and meta-analysis","volume":"16","author":"Ahmed Mohamed","year":"2025","journal-title":"Front Endocrinol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"5126","DOI":"10.1007\/s00586-025-09111-5","article-title":"Risk factors for adjacent vertebral fracture after kyphoplasty or percutaneous vertebroplasty in osteoporotic vertebral systematic review and meta-analysis compression fractures","volume":"34","author":"He","year":"2025","journal-title":"Eur Spine J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1186\/s12891-025-08731-8","article-title":"Prevalence and risk factors for residual back pain after percutaneous vertebral augmentation in osteoporotic vertebral compression fracture patients: a systematic review and meta-analysis","volume":"26","author":"Chen","year":"2025","journal-title":"BMC Musculoskelet Disord."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1186\/s13018-025-06424-5","article-title":"Risk factors for new vertebral compression fracture following percutaneous vertebral augmentation: a systematic review and meta-analysis based on multivariate logistic regression analysis","volume":"20","author":"Liu","year":"2025","journal-title":"J Orthop Surg Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1007\/s00198-025-07609-8","article-title":"Incidence and predictors of residual back pain after percutaneous vertebral augmentation in osteoporotic vertebral compression fracture: a systematic review and meta analysis","volume":"36","author":"Lyu","year":"2025","journal-title":"Osteoporos Int."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3109","DOI":"10.3390\/jcm14093109","article-title":"Paraspinal muscle fat infiltration as a key predictor of symptomatic intravertebral vacuum cleft: a machine learning approach","volume":"14","author":"Ahn","year":"2025","journal-title":"J Clin Med."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1595231","DOI":"10.3389\/fsurg.2025.1595231","article-title":"Safety and efficacy of robot-assisted percutaneous kyphoplasty under local anesthesia in a day-surgery setting for osteoporotic vertebral compression fractures","volume":"12","author":"Wu","year":"2025","journal-title":"Front Surg."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1594217","DOI":"10.3389\/fsurg.2025.1594217","article-title":"Incidence of new osteoporotic adjacent vertebral body fractures. A comparison between conservative treatment and vertebral body augmentation (vertebroplasty, kyphoplasty): a systematic review and meta-analysis","volume":"12","author":"Korovessis","year":"2025","journal-title":"Front Surg"},{"key":"B37","doi-asserted-by":"publisher","first-page":"100576","DOI":"10.1016\/j.xnsj.2024.100576","article-title":"The effect of time to balloon kyphoplasty on osteoporotic vertebral compression fractures: a systematic review with meta-analysis","volume":"21","author":"Khan","year":"2024","journal-title":"N Am Spine Soc J."},{"key":"B38","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1186\/s13018-025-05868-z","article-title":"Bone cement distribution patterns in vertebral augmentation for osteoporotic vertebral compression fractures: a systematic review","volume":"20","author":"Yang","year":"2025","journal-title":"J Orthop Surg Res."}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1841245\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T04:34:45Z","timestamp":1780979685000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1841245\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,9]]},"references-count":38,"alternative-id":["10.3389\/fnut.2026.1841245"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1841245","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,9]]},"article-number":"1841245"}}