{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:09:49Z","timestamp":1779170989263,"version":"3.51.4"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Childhood asthma is a major public health concern. Current evidence regarding vitamin D supplementation in childhood asthma remains inconsistent, particularly with respect to pulmonary function. This study comprehensively evaluates the role of vitamin D supplementation in childhood asthma, with a particular focus on lung function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>PubMed, EMBASE, Web of Science, and the Cochrane Library were searched through October 31, 2025 for RCTs. Data were extracted and analyzed using FEV1 (%) as the primary outcome measure, and FVC (%), FEV1\/FVC, PEF, FeNO, cACT, and IgE as secondary outcome measures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twelve RCTs (\n                      <jats:italic>n<\/jats:italic>\n                      = 1239) were included. We did not find evidence that vitamin D supplementation improves lung function [FEV1 (%): SMD: 0.39, 95% CI: \u20130.13 to 0.92; FVC (%): SMD: 0.13, 95% CI: \u20130.73 to 0.98; FEV1\/FVC: MD: 0.56, 95% CI: \u20137.24 to 8.35; PEF: MD: -3.69, 95% CI: \u20139.71 to 2.34] or cACT scores (MD: 0.16, 95% CI: \u20130.55 to 0.88), nor does it reduce FeNO or IgE levels (SMD: \u20130.14, 95% CI: \u20130.61 to 0.33) in children with asthma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vitamin D supplementation showed no overall benefit for lung function, IgE levels, FeNO, or cACT scores in children with asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:ext-link>\n                      , identifier CRD420251270660.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1842895","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T05:42:25Z","timestamp":1779169345000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The efficacy of vitamin D supplementation in the management of childhood asthma: a systematic review and meta-analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Runze","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaiyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shengjing Hospital of China 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