{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:30:31Z","timestamp":1789648231729,"version":"4.0.0"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Intestinal dysbiosis is a disorder of the gut microbiome, characterized by a loss of equilibrium between the microorganisms found in the gastrointestinal tract and their hosts. It leads to metabolic changes in both the gut and in the body\u2019s inflammatory response, and adversely affects the epithelial cells that line the intestines. This article aimed to study the mechanisms whereby three metabolites, produced from\n                      <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                      , including 2,4-decadienal, (Z)-ethyl heptadec-9-enoate, and octadecanoic acid, may alter protein activity associated with diseases of the gut.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using a variety of in-silico methods, including ADMET modeling and prediction, docking of two target proteins, Fatty Acid\u2013Binding Protein 4 (FABP4) and B-Raf Proto-Oncogene, Serine\/Threonine Kinase (BRAF), and molecular normal mode analysis and network pharmacology, we investigated the potential interaction of these compounds. Dynamics simulation was performed using GROMACS (2019.2) and GROMOS96 (43a1) force fields.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results and discussion<\/jats:title>\n                    <jats:p>\n                      ADMET indicates good oral absorption, moderate ability to dissolve in your intestinal tract (lipophilicity), and low toxicity when consumed. Additionally, molecular docking techniques indicated that metabolite-protein binding is stable via primarily hydrophobic bonds, hydrogen bonds, and all have similar binding energies in the range of \u22125.1 to \u22126.2 kcal\/mol. Normal mode analysis and dynamic simulation confirmed that the metabolite-protein complexes were stable. Network pharmacology studies suggest that the use of\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      -derived metabolites as BRAF and FABP4 regulators of dysbiosis in the gut may result in therapeutic targets to restore homeostasis in the epithelial lining of the intestines and reduce inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This work demonstrates the protective potential against intestinal dysbiosis of primary metabolites of\n                      <jats:italic>L. plantarum<\/jats:italic>\n                      . However, future experiments are essential to verify the predictions made from the in silico studies and optimize various types of metabolite-based treatments.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1844467","type":"journal-article","created":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T09:57:56Z","timestamp":1781258276000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluating the anti-gut dysbiotic potential of bioactive primary metabolites derivatives from Lactaplantibacillus plantarum 12\u20133. An integrated ADMET, network pharmacology, molecular docking and normal mode analysis approaches"],"prefix":"10.3389","volume":"13","author":[{"given":"Tariq","family":"Aziz","sequence":"first","affiliation":[{"name":"State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering, Shenzhen University","place":["Shenzhen, China"]},{"name":"School of Biomedical Engineering Shenzhen University","place":["Shenzhen, Guangdong, China"]},{"name":"Key Laboratory of Geriatric Nutrition and Health of Ministry of Education, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel Pascal","family":"Owona","sequence":"additional","affiliation":[{"name":"Department of Animal Biology and Physiology, Laboratory of Animal Physiology, Faculty of Science, University of Yaound\u00e9 1","place":["Yaound\u00e9, Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u00e8ge Th\u00e9r\u00e8se Amougou","family":"Okoa","sequence":"additional","affiliation":[{"name":"Department of Animal Biology and Physiology, Laboratory of Environment and Hydrobiology, Faculty of Science, University of Yaound\u00e9 1","place":["Yaound\u00e9, Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengue Ngadena Yolande","family":"Sandrine","sequence":"additional","affiliation":[{"name":"Department of Animal Biology and Physiology, Laboratory of Animal Physiology, Faculty of Science, University of Yaound\u00e9 1","place":["Yaound\u00e9, Cameroon"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inam Ur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Fuli Institute of Food Science, College of Biosystems Engineering and Food Science, Zhejiang University Hangzhou","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abid","family":"Sarwar","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health of Ministry of Education, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Intelligent Construction and Healthy Operation and Maintenance of Deep Underground Engineering, Shenzhen University","place":["Shenzhen, China"]},{"name":"School of Biomedical Engineering Shenzhen University","place":["Shenzhen, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhennai","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Geriatric Nutrition and Health of Ministry of Education, Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metab","family":"Alharbi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University Riyadh","place":["Riyadh, Saudi Arabia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah F.","family":"Alasmari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University Riyadh","place":["Riyadh, Saudi 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