{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T05:20:56Z","timestamp":1787721656399,"version":"build-2784847793"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the association between PNI and GNRI with in-hospital MACE after PCI in patients with ACS, and to compare the predictive value of these two nutritional assessment tools. The optimal cutoff values of PNI and GNRI were determined by calculating the maximum Youden\u2019s index based on ROC curve analysis in the training cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicenter retrospective cohort study included ACS patients who underwent PCI at three hospitals between January 2021 and December 2024. The training cohort consisted of 638 patients from Anhui Provincial Hospital, while the validation cohort included 212 patients from Hefei Second People\u2019s Hospital and 238 patients from Ma\u2019anshan People\u2019s Hospital. PNI was calculated based on serum albumin and lymphocyte count at admission, while GNRI was calculated using serum albumin and body mass index. The primary endpoint was in-hospital MACE, including all-cause mortality, myocardial infarction, stroke, and target vessel revascularization. Multivariate logistic regression analysis was used to assess the association of PNI and GNRI with in-hospital MACE, and the predictive abilities of the two indices were compared using ROC curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the training cohort, 63 patients (9.9%) experienced in-hospital MACE. Multivariate analysis showed that low PNI (&amp;lt;45.2) and low GNRI (&amp;lt;98.0) were both independent predictors of in-hospital MACE (PNI: adjusted OR\u202f=\u202f2.37, 95%CI: 1.42\u20133.96,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.001; GNRI: adjusted OR\u202f=\u202f2.18, 95%CI: 1.31\u20133.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.003). ROC analysis revealed that PNI (AUC\u202f=\u202f0.721, 95%CI: 0.653\u20130.789) and GNRI (AUC\u202f=\u202f0.703, 95%CI: 0.632\u20130.774) had similar predictive values (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.247). Similar results were observed in the validation cohort, and DeLong test confirmed no significant difference in AUC values of the two indices between training and validation cohorts, confirming the reliability of these findings. The combination of both nutritional indices (AUC\u202f=\u202f0.753, 95%CI: 0.687\u20130.819) showed superior predictive ability compared to either index alone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Both PNI and GNRI serve as effective predictive tools for in-hospital MACE after PCI in ACS patients. The two nutritional assessment tools have similar predictive capabilities, and their combination may provide more accurate risk assessment. Routine nutritional status evaluation in ACS patients helps identify high-risk individuals, providing a basis for early intervention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1848510","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T04:49:03Z","timestamp":1787719743000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic nutritional index and geriatric nutritional risk index as predictors of in-hospital major adverse cardiovascular events after percutaneous coronary intervention in acute coronary syndrome patients: a multicenter retrospective cohort study"],"prefix":"10.3389","volume":"13","author":[{"given":"Jun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, Chongming Hospital Affiliated to Shanghai University of Medicine and Health Sciences","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fachao","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Maanshan People's Hospital","place":["Maanshan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caoyang","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Emergency, First Affiliated Hospital of University of Science and Technology of China, Anhui Provincial Hospital","place":["Hefei, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart disease and stroke statistics-2019 update: a report from the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jacc.2017.04.052","article-title":"Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990\u20132015","volume":"70","author":"Roth","year":"2017","journal-title":"J Am Coll Cardiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.11909\/j.issn.1671-5411.2017.01.012","article-title":"China cardiovascular diseases report 2015: a summary","volume":"14","author":"Chen","year":"2017","journal-title":"J Geriatr Cardiol JGC"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"828","DOI":"10.1016\/j.jacc.2020.06.058","article-title":"Prevalence and prognostic significance of malnutrition in patients with acute coronary syndrome","volume":"76","author":"Raposeiras Roub\u00edn","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"829","DOI":"10.3390\/nu9080829","article-title":"Evaluation of blood biomarkers associated with risk of malnutrition in older adults: a systematic review and meta-analysis","volume":"9","author":"Zhang","year":"2017","journal-title":"Nutrients"},{"key":"ref6","first-page":"1001","article-title":"Prognostic nutritional index in gastrointestinal surgery of malnourished cancer patients","volume":"85","author":"Onodera","year":"1984","journal-title":"Nihon Geka Gakkai Zasshi"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1093\/ajcn\/82.4.777","article-title":"Geriatric nutritional risk index: a new index for evaluating at-risk elderly medical patients","volume":"82","author":"Bouillanne","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"e015649","DOI":"10.1136\/bmjopen-2016-015649","article-title":"Controlling Nutritional Status (CONUT) score as a predictor of all-cause mortality in elderly hypertensive patients: a prospective follow-up study","volume":"7","author":"Sun","year":"2017","journal-title":"BMJ Open"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"e004876","DOI":"10.1161\/JAHA.116.004876","article-title":"Prognostic nutritional index and the risk of mortality in patients with acute heart failure","volume":"6","author":"Cheng","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1253\/circj.CJ-12-1091","article-title":"Geriatric nutritional risk index predicts functional dependency and mortality in patients with heart failure with preserved ejection fraction","volume":"77","author":"Kinugasa","year":"2013","journal-title":"Circ J"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.numecd.2017.01.005","article-title":"A novel and useful predictive indicator of prognosis in ST-segment elevation myocardial infarction, the prognostic nutritional index","volume":"27","author":"Keskin","year":"2017","journal-title":"Nutr Metab Cardiovasc Dis NMCD"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ahj.2018.04.021","article-title":"Importance of geriatric nutritional risk index assessment in patients undergoing transcatheter aortic valve replacement","volume":"202","author":"Shibata","year":"2018","journal-title":"Am Heart J"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1007\/s00380-018-1201-x","article-title":"Combined effect of nutritional status on long-term outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention","volume":"33","author":"Wada","year":"2018","journal-title":"Heart Vessel"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3747\/pdi.2012.00018","article-title":"Geriatric nutritional risk index as a prognostic factor in peritoneal dialysis patients","volume":"33","author":"Kang","year":"2013","journal-title":"Perit Dial Int"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3348\/kjr.2018.0479","article-title":"Recent issues on body composition imaging for sarcopenia evaluation","volume":"20","author":"Lee","year":"2019","journal-title":"Korean J Radiol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"e38","DOI":"10.1161\/CIR.0000000000000350","article-title":"Heart disease and stroke statistics-2016 update: a report from the American Heart Association","volume":"133","author":"Mozaffarian","year":"2016","journal-title":"Circulation"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1111\/j.0894-0959.2004.17603.x","article-title":"Serum albumin: relationship to inflammation and nutrition","volume":"17","author":"Don","year":"2004","journal-title":"Semin Dial"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1161\/CIRCHEARTFAILURE.112.970525","article-title":"Predictive value of low relative lymphocyte count in patients hospitalized for heart failure with reduced ejection fraction: insights from the EVEREST trial","volume":"5","author":"Vaduganathan","year":"2012","journal-title":"Circ Heart Fail"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e079954","DOI":"10.1136\/bmjopen-2023-079954","article-title":"Association between extremely high prognostic nutritional index and all-cause mortality in patients with coronary artery disease: secondary analysis of a prospective cohort study in China","volume":"14","author":"Wu","year":"2024","journal-title":"BMJ Open"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.ijcard.2017.01.008","article-title":"Impact of nutritional assessment and body mass index on cardiovascular outcomes in patients with stable coronary artery disease","volume":"230","author":"Kunimura","year":"2017","journal-title":"Int J Cardiol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.ijcard.2016.12.064","article-title":"Prognostic value of malnutrition assessed by controlling nutritional status score for long-term mortality in patients with acute heart failure","volume":"230","author":"Iwakami","year":"2017","journal-title":"Int J Cardiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.jacc.2018.08.1038","article-title":"Fourth Universal Definition of Myocardial Infarction","volume":"72","author":"Thygesen","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"ESC Scientific Document Group. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC)","volume":"9","author":"Ib\u00e1nez","year":"2018","journal-title":"Eur Heart J"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.1038\/s41598-024-53540-z","article-title":"Prognostic value of geriatric nutritional risk index and systemic immune-inflammatory index in elderly patients with acute coronary syndromes","volume":"14","author":"Zhu","year":"2024","journal-title":"Sci 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