{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T06:18:26Z","timestamp":1787811506246,"version":"build-2784847793"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Insulin resistance (IR) is a key factor in cardiometabolic diseases, but there are few practical ways to measure it in adolescents. The insulin sensitivity\u2019s surrogate measure, the eGDR, has not been well validated in young populations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>eGDR was determined by the use of waist circumference (WC), HbA1c levels, and hypertension status in this cross-sectional study of Chinese adolescents. Restricted cubic spline models and multivariate logistic regression were utilized to estimate associations between eGDR and cardiometabolic risk factors (CMRFs), such as dyslipidemia, hyperuricemia, and high fasting plasma glucose (FPG). The eGDR\u2019s discriminative performance was compared with traditional IR indices, such as HOMA-IR, TyG, AIP, TyG-BMI, and QUIKI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After confounders\u2019 adjustment, each SD raise in eGDR was linked with reduced odds of dyslipidemia (OR\u202f=\u202f0.781, 95% CI: 0.703\u20130.866,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001) and hyperuricemia (OR\u202f=\u202f0.884, 95% CI: 0.800\u20130.977,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.016). eGDR showed negative correlations with atherogenic lipid subfractions, such as LDL-C, non-HDL-C, and triglycerides (TG), but not with total cholesterol (TC) or FPG. Subgroup analyses showed that the protective effect against dyslipidemia was stronger in participants with BMI in the \u2265 85th percentile, and sex-specific differences in the associations with TG and FPG. eGDR was found to be better than traditional IR indices in discriminating clustered CMRFs. Sex-specific cut-offs for IR were determined: eGDR &amp;lt;8.06\u202fmg\/kg\/min and &amp;lt;8.46\u202fmg\/kg\/min for males and females, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>eGDR is a strong, non-invasive cardiometabolic risk indicator in adolescents, especially dyslipidemia and hyperuricemia. It can offer a feasible instrument of early risk stratification in this group.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1853266","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T05:35:10Z","timestamp":1787808910000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Insulin resistance evaluated by estimated glucose disposal rate and its association with cardiometabolic risk factors among adolescents in Northeast China"],"prefix":"10.3389","volume":"13","author":[{"given":"Yiwen","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Jinghua Hospital","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runyu","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12933-020-01052-1","article-title":"Cardiovascular morbidity, diabetes and cancer risk among children and adolescents with severe obesity","volume":"19","author":"Bendor","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13114176","article-title":"Obesity and cardiometabolic risk factors: from childhood to adulthood","volume":"13","author":"Drozdz","year":"2021","journal-title":"Nutrients"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12933-018-0762-4","article-title":"Association between insulin resistance and the development of cardiovascular disease","volume":"17","author":"Ormazabal","year":"2018","journal-title":"Cardiovasc Diabetol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"154766","DOI":"10.1016\/j.metabol.2021.154766","article-title":"Insulin resistance, cardiovascular stiffening and cardiovascular disease","volume":"119","author":"Hill","year":"2021","journal-title":"Metabolism"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41574-025-01114-y","article-title":"Insulin resistance in type 2 diabetes mellitus","volume":"21","author":"Accili","year":"2025","journal-title":"Nat Rev Endocrinol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.4093\/dmj.2021.0280","article-title":"Insulin resistance: from mechanisms to therapeutic strategies","volume":"46","author":"Lee","year":"2022","journal-title":"Diabetes Metab J"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1458742","DOI":"10.3389\/fendo.2024.1458742","article-title":"Editorial: cardiovascular diseases related to diabetes and obesity - 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