{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:48:01Z","timestamp":1782366481126,"version":"3.54.5"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>\n                    Mucositis is a common debilitating complication of chemotherapy in cancer patients that limits enteral nutrition, causes diarrhea, dehydration and electrolyte wasting. 2\u2019-fucosyllactose (2\u2019-FL), a non-digestible oligosaccharide initially isolated from human milk, is critical in the development of gastrointestinal function and microbiome maturation in the newborn. Here, we demonstrate, that supplementation of 2\u2019-FL in a medical food with magnesium (Humolyte\u00ae), protects Wistar rats from gastrointestinal mucosal injury from chemotherapeutic drugs doxorubicin, irinotecan, 5-flurouracil, and cisplatin. Supplementation with Humolyte\u00ae reduced weight loss and the severity of diarrhea from chemotherapy. Histopathology of ileal and colonic tissue showed preservation of overall mucosal anatomy including goblet cells and a markedly lesser inflammation. Humolyte\u00ae reduced hypertrophy and edema of oral mucosa caused by chemotherapy.\n                    <jats:italic>In vitro<\/jats:italic>\n                    , Humolyte\u00ae improved goblet cell survival and mucin secretion while reducing monolayer permeability. Thus, Humolyte\u00ae can be a useful adjunctive therapy for patients with cancer suffering from chemotherapy-induced mucositis.\n                  <\/jats:p>","DOI":"10.3389\/fnut.2026.1859479","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:31:27Z","timestamp":1782365487000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Supplementation with 2\u2032-fucosyllactose, a prebiotic human milk oligosaccharide (HMO), in a magnesium-containing medical food reduces chemotherapy-induced mucositis in Wistar rats"],"prefix":"10.3389","volume":"13","author":[{"given":"Sourabh","family":"Kharait","sequence":"first","affiliation":[{"name":"IGH Naturals, Inc.","place":["Rocklin, CA, United States"]},{"name":"Department of Medicine, Columbia University Medical Center","place":["New York, NY, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Wilcox","sequence":"additional","affiliation":[{"name":"Aelius Biotechnology","place":["Newcastle upon Tyne, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Stockdale-Stanforth","sequence":"additional","affiliation":[{"name":"Aelius Biotechnology","place":["Newcastle upon Tyne, United Kingdom"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishnu","family":"Thakare","sequence":"additional","affiliation":[{"name":"Scitesla Research Private Limited","place":["Navi Mumbai, India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s11912-015-0474-9","article-title":"Management of Mucositis during Chemotherapy: from pathophysiology to pragmatic 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