{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:16:57Z","timestamp":1788239817894,"version":"build-2803163510"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"\n Objective<\/jats:title>\n To investigate body composition changes in patients with stable chronic obstructive pulmonary disease (COPD) and their correlation with disease severity, and to assess the value of body composition indices for early identification of concomitant sarcopenia.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Patients with stable COPD were stratified according to the comprehensive disease severity assessment method in the Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, changes in body mass index (BMI), skeletal muscle index (SMI), body fat mass index (BFMI), and fat-free mass index (FFMI) were observed across groups. Factors associated with concomitant sarcopenia in COPD were analyzed, and Receiver Operating Characteristic (ROC) curves were plotted to evaluate the predictive value of the body composition indices for early screening of concomitant sarcopenia in patients with stable COPD.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A total of 237 patients with stable COPD (including 40 with concomitant sarcopenia) and 270 healthy controls were enrolled. In the stable COPD group, BMI, SMI, and FFMI were all positively correlated with FEV\u2081%pred and FEV\u2081\/FVC (all\n p<\/jats:italic>\n \u202f&lt;\u202f0.05), with correlation coefficients ranging from 0.142 to 0.194, and negatively correlated with modified Medical Research Council (mMRC) dyspnea score, COPD Assessment Test (CAT) score, and number of acute exacerbations in the past 1\u202fyear (\n r<\/jats:italic>\n \u202f=\u202f\u22120.405, \u22120.405, \u22120.174,\n p<\/jats:italic>\n \u202f&lt;\u202f0.01;\n r<\/jats:italic>\n \u202f=\u202f\u22120.336, \u22120.298, \u22120.208,\n p<\/jats:italic>\n \u202f&lt;\u202f0.01). SMI and FEV\u2081%pred were independent predictors of concomitant sarcopenia (OR\u202f=\u202f0.011, 0.868;\n p<\/jats:italic>\n \u202f&lt;\u202f0.05). The combined SMI and FEV\u2081%pred showed superior diagnostic performance (AUC\u202f=\u202f0.990, 95%CI: 0.981\u20130.998).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Body composition alterations occur during the stable phase of COPD, especially a reduction in skeletal muscle mass. Changes in skeletal muscle indices in patients with stable COPD are significantly correlated with disease severity. Body composition analysis has potential clinical value for early identification of skeletal muscle impairment and disease assessment in stable COPD patients, and may be considered as a supplementary component of routine follow-up.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fnut.2026.1862289","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:26:58Z","timestamp":1788236818000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Body composition in stable COPD: associations with disease severity and early sarcopenia prediction"],"prefix":"10.3389","volume":"13","author":[{"given":"Huifang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First People\u2019s Hospital of Yinchuan, The Second Clinical Medical College of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenkai","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, General Hospital of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanxia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First People\u2019s Hospital of Yinchuan, The Second Clinical Medical College of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First People\u2019s Hospital of Yinchuan, The Second Clinical Medical College of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhe","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First People\u2019s Hospital of Yinchuan, The Second Clinical Medical College of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First People\u2019s Hospital of Yinchuan, The Second Clinical Medical College of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First People\u2019s Hospital of Yinchuan, The Second Clinical Medical College of Ningxia Medical University","place":["Yinchuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"108635","DOI":"10.1016\/j.pharmthera.2024.108635","article-title":"Musculoskeletal crosstalk in chronic obstructive pulmonary disease and comorbidities: emerging roles and therapeutic potentials","volume":"257","author":"Mou","year":"2024","journal-title":"Pharmacol Ther"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1016\/S0140-6736(18)30841-9","article-title":"Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China pulmonary health [CPH] study): a national cross-sectional study","volume":"391","author":"Wang","year":"2018","journal-title":"Lancet"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"101065","DOI":"10.1016\/j.lanwpc.2024.101065","article-title":"Cost-effectiveness of population-based screening for chronic obstructive pulmonary disease in China: a simulation modeling study","volume":"46","author":"Chen","year":"2024","journal-title":"Lancet Reg Health West Pac"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"102597","DOI":"10.1016\/j.eclinm.2024.102597","article-title":"The care cascade of chronic obstructive pulmonary disease in China: a cross-sectional study of individual-level data at enrolment into the national 'happy breathing' Programme","volume":"74","author":"Wang","year":"2024","journal-title":"EClinicalMedicine"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"100619","DOI":"10.1016\/j.lanepe.2023.100619","article-title":"Identification of key opportunities for optimising the management of high-risk COPD patients in the UK using the CONQUEST quality standards: an observational longitudinal study","volume":"29","author":"Halpin","year":"2023","journal-title":"Lancet Reg Health Eur"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1001\/jama.2025.7358","article-title":"A multidimensional diagnostic approach for chronic obstructive pulmonary disease","volume":"333","author":"Bhatt","year":"2025","journal-title":"JAMA"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"6454","DOI":"10.3390\/ijms24076454","article-title":"Main pathogenic mechanisms and recent advances in COPD peripheral skeletal muscle wasting","volume":"24","author":"Henrot","year":"2023","journal-title":"Int J Mol Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"17534666231208633","DOI":"10.1177\/17534666231208633","article-title":"Role of Nrf2 and exercise in alleviating COPD-induced skeletal muscle dysfunction","volume":"17","author":"Jiang","year":"2023","journal-title":"Ther Adv Respir Dis"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1183\/09031936.00070914","article-title":"Nutritional assessment and therapy in COPD: a European Respiratory Society statement","volume":"44","author":"Schols","year":"2014","journal-title":"Eur Respir J"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"358","DOI":"10.62347\/OGUT1532","article-title":"Correlation of lung function and sarcopenia in elderly patients with chronic obstructive pulmonary disease and analysis of factors influencing sarcopenia","volume":"17","author":"Yang","year":"2025","journal-title":"Am J Transl Res"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.2147\/COPD.S396728","article-title":"Impaired skeletal muscle in patients with stable chronic obstructive pulmonary disease (COPD) compared with non-COPD patients","volume":"18","author":"Wu","year":"2023","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"100879","DOI":"10.1016\/j.rh.2024.100879","article-title":"The challenge of applying the F-A-C-S pathway from EWGSOP2 for sarcopenia diagnosis in patients with chronic obstructive pulmonary disease: a diagnostic accuracy study","volume":"59","author":"Hoz-San Bartolom\u00e9","year":"2025","journal-title":"Rehabil"},{"key":"ref13","year":"2023"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"272","DOI":"10.4046\/trd.2023.0008","article-title":"Low skeletal muscle mass and clinical outcomes in chronic obstructive pulmonary disease","volume":"86","author":"Choi","year":"2023","journal-title":"Tuberc Respir Dis (Seoul)"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1097\/CM9.0000000000003131","article-title":"Reflections on COPD comorbidities","volume":"137","author":"He","year":"2024","journal-title":"Chin Med J"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1404615","DOI":"10.3389\/fimmu.2024.1404615","article-title":"Inflammation mechanism and research progress of COPD","volume":"15","author":"Xu","year":"2024","journal-title":"Front Immunol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"133741","DOI":"10.1016\/j.ijbiomac.2024.133741","article-title":"Predictive and therapeutic value of lipoprotein-associated phospholipaseA2 in sarcopenia in chronic obstructive pulmonary disease","volume":"275","author":"Liao","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"115664","DOI":"10.1016\/j.bcp.2023.115664","article-title":"Oxidative stress: roles in skeletal muscle atrophy","volume":"214","author":"Zhang","year":"2023","journal-title":"Biochem Pharmacol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"3291","DOI":"10.14336\/AD.2024.1129","article-title":"Mitochondrial quality control: a new perspective in skeletal muscle dysfunction of chronic obstructive pulmonary disease","volume":"16","author":"Song","year":"2024","journal-title":"Aging Dis"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1002\/jcsm.13198","article-title":"Gene polymorphisms associated with heterogeneity and senescence characteristics of sarcopenia in chronic obstructive pulmonary disease","volume":"14","author":"Attaway","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"190049","DOI":"10.1183\/16000617.0049-2019","article-title":"Sarcopenia in COPD: a systematic review and meta-analysis","volume":"28","author":"Benz","year":"2019","journal-title":"Eur Respir Rev"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/s12890-024-03034-5","article-title":"Prevalence and clinical characteristics of sarcopenia in older adult patients with stable chronic obstructive pulmonary disease: a cross-sectional and follow-up study","volume":"24","author":"Kim","year":"2024","journal-title":"BMC Pulm Med"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"101587","DOI":"10.1016\/j.rehab.2021.101587","article-title":"Quadriceps weakness associated with mortality in individuals with chronic obstructive pulmonary disease","volume":"65","author":"Spositon","year":"2022","journal-title":"Ann Phys Rehabil Med"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s12877-023-03784-7","article-title":"Sarcopenia index as a predictor of clinical outcomes among older adult patients with acute exacerbation of chronic obstructive pulmonary disease: a cross-sectional study","volume":"23","author":"Zhao","year":"2023","journal-title":"BMC Geriatr"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.jamda.2019.12.012","article-title":"Asian working Group for Sarcopenia: 2019 consensus update on sarcopenia diagnosis and treatment","volume":"21","author":"Chen","year":"2020","journal-title":"J Am Med Dir Assoc"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.clnu.2016.09.004","article-title":"ESPEN guidelines on definitions and terminology of clinical nutrition","volume":"36","author":"Cederholm","year":"2017","journal-title":"Clin Nutr"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1183\/09031936.00197314","article-title":"Antagonistic implications of sarcopenia and abdominal obesity on physical performance in COPD","volume":"46","author":"Van de Bool","year":"2015","journal-title":"Eur Respir J"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"107346","DOI":"10.1016\/j.rmed.2023.107346","article-title":"Differential impacts between fat mass index and fat-free mass index on patients with COPD","volume":"217","author":"Shimada","year":"2023","journal-title":"Respir Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1449189","DOI":"10.3389\/fnut.2024.1449189","article-title":"Body compositions phenotypes of older adults with COPD","volume":"11","author":"Kalu\u017aniak-Szymanowska","year":"2024","journal-title":"Front Nutr"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"33","DOI":"10.14336\/AD.2022.0603","article-title":"Skeletal muscle mitochondrial dysfunction in chronic obstructive pulmonary disease: underlying mechanisms and physical therapy perspectives","volume":"14","author":"Wang","year":"2023","journal-title":"Aging Dis"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1304384","DOI":"10.3389\/fmed.2024.1304384","article-title":"Correlation between body composition and disease severity in patients with chronic obstructive pulmonary disease","volume":"11","author":"Jin","year":"2024","journal-title":"Front Med (Lausanne)"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1016\/S0140-6736(24)01210-8","article-title":"Obesity in adults","volume":"404","author":"Lingvay","year":"2024","journal-title":"Lancet"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1862289\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:26:59Z","timestamp":1788236819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1862289\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":32,"alternative-id":["10.3389\/fnut.2026.1862289"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1862289","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"article-number":"1862289"}}