{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:53:36Z","timestamp":1791212016478,"version":"4.1.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Evidence regarding the association between fasting serum uric acid (FSUA) and Alzheimer's disease (AD) is limited and inconsistent. This study investigated the association between FSUA levels and AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this cross-sectional study, 852 participants from a hospital specializing in geriatric care were enrolled. Multivariable logistic regression analysis, restricted cubic spline curves, and subgroup analyses were employed to analyze the association between FSUA and AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The average age of eligible participants was 81.0 \u00b1 8.8 years; 23% were patients with AD and 33.7% were male. Multivariate logistic regression analysis revealed an inverse relationship between FSUA levels and AD. Specifically, a 10 \u03bcmol\/L increase in FSUA was associated with a 5% decrease in AD odds (OR, 0.95; 95% confidence interval [CI], 0.93\u20130.97). When FSUA levels were divided into quartiles, the higher quartiles showed progressively lower odds of developing AD than those in the lowest quartiles (\n                      <jats:italic>p<\/jats:italic>\n                      for trend &amp;lt; 0.001). No interactions were observed between FSUA and AD. Restricted cubic spline regression model demonstrated a linear inverse association between the odds of AD and FSUA levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We observed a negative association between FSUA levels and AD. Further prospective studies are required to confirm this causal relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1878852","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:16:12Z","timestamp":1786025772000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between fasting serum uric acid levels and Alzheimer's disease in nursing home residents: a cross-sectional study"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaoyu","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neurology, Guangzhou Geriatric Hospital, Guangzhou","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Child and Adolescent Psychological and Behavioral Medicine, Shandong Mental Health Center, Shandong University, Jinan","place":["Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchi","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Guangzhou Geriatric Hospital, Guangzhou","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Guangzhou Geriatric Hospital, Guangzhou","place":["Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2333721420962669","DOI":"10.1177\/2333721420962669","article-title":"Maintaining resident social connections during COVID-19: considerations for long-term care","volume":"6","author":"Ickert","year":"2020","journal-title":"Gerontol Geriatr 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