{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:18:40Z","timestamp":1787635120683,"version":"build-2736575974"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Large-scale data on vitamin D status in early-pregnant women in high-risk Northern China are scarce. This study evaluated the decadal trends (2016\u20132025) and associated factors of serum 25(OH)D levels in this population in Shanxi Province.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort included 20,693 early-pregnant women (&amp;lt;14\u202fweeks). Serum 25(OH)D was measured. Logistic regression assessed associations with of season, age, conception mode, and the COVID-19 period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median 25(OH)D was 36.12\u202fnmol\/L, indicating a concerning status. Season was the strongest associated factor. The pandemic period (2020\u20132022) saw a significant rise in severe deficiency (&amp;lt;30\u202fnmol\/L) to 35.6%. Advanced maternal age (\u226535) and ART conception were linked to higher levels. Summer and autumn were protective factors for sufficiency, while natural conception was an associated factor for deficiency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Severe vitamin D deficiency is widespread. Findings advocate for routine perinatal vitamin D screening and supplementation, with tailored strategies for winter and specific subgroups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1881959","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:23:02Z","timestamp":1787631782000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A decade-long assessment reveals persistent vitamin D deficiency and its associated factors in early-pregnant women from northern China (2016\u20132025)"],"prefix":"10.3389","volume":"13","author":[{"given":"Haizhen","family":"Chen","sequence":"first","affiliation":[{"name":"Laboratory Department, Shanxi Provincial Children\u2019s Hospital","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Yun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shanxi Medical University","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xitian","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shanxi Medical University","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunli","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Intensive Care Unit, Shanxi Provincial Children\u2019s Hospital","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shanxi Medical University","place":["Taiyuan, Shanxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1080\/10408363.2022.2070595","article-title":"Vitamin D: sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites","volume":"59","author":"Janou\u0161ek","year":"2022","journal-title":"Crit Rev Clin Lab Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"S116","DOI":"10.1111\/j.1753-4887.2008.00094.x","article-title":"Vitamin D\u2019s role in cell proliferation and differentiation","volume":"66","author":"Samuel","year":"2008","journal-title":"Nutr Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"100032","DOI":"10.1016\/j.pharmr.2024.100032","article-title":"Vitamin D and its analogs in immune system regulation","volume":"77","author":"Artusa","year":"2025","journal-title":"Pharmacol Rev"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"767","DOI":"10.3390\/nu15030767","article-title":"Genomic or non-genomic? 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