{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:21:09Z","timestamp":1792027269191,"version":"4.4.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T00:00:00Z","timestamp":1780876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Low magnesium status has been linked to cerebrovascular conditions that overlap with pathways implicated in dementia, yet prior studies have relied on single magnesium measurements obtained in earlier population-based cohorts. Whether repeatedly documented low magnesium status is associated with incident dementia in real-world clinical populations is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective propensity score-matched cohort study used data from the TriNetX Global Collaborative Network (2016\u20132023). Adults aged \u226550\u202fyears with two serum magnesium values &amp;lt;1.7\u202fmg\/dL within a 1-year window were compared with matched controls with two normal values (1.70\u20132.20\u202fmg\/dL). A 1-year landmark period was applied before the outcome ascertainment. The primary outcome was incident all-cause dementia. The secondary outcomes included dementia subtypes, stroke, and mortality. Prespecified positive and negative control outcomes, subgroup and sensitivity analyses, sequential multivariable Cox regression, and an exploratory analysis of high magnesium status were conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      After propensity score matching, 162,936 patients were included in each group. Low magnesium status was associated with incident all-cause dementia (HR 1.33; 95% CI, 1.26\u20131.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), with the strongest association observed for vascular dementia (HR 1.63; 95% CI, 1.42\u20131.88,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). Associations were also observed for stroke (HR 1.37,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001) and mortality (HR 1.52,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001). The results remained consistent across the sensitivity and multivariable analyses. High magnesium status was associated with all-cause dementia (HR 1.25,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001) and vascular dementia (HR 1.40,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), but not Alzheimer\u2019s disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Repeatedly documented low magnesium status was associated with an increased risk of incident all-cause dementia, particularly vascular dementia, suggesting a potential role of magnesium homeostasis in long-term cognitive function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1886820","type":"journal-article","created":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T04:22:48Z","timestamp":1780892568000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between low magnesium status and new-onset dementia in the general population: a propensity score-matched cohort study"],"prefix":"10.3389","volume":"13","author":[{"given":"Ying-Jen","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Chi Mei Medical Center","place":["Tainan City, Taiwan"]},{"name":"Department of Recreation and Health-Care Management, College of Recreation and Health Management, Chia Nan University of Pharmacy and Science","place":["Tainan City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Li","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, E-Da Hospital, I-Shou University","place":["Kaohsiung City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Mao","family":"Lan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Chi Mei Hospital, Liouying","place":["Tainan City, Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e074787","DOI":"10.1136\/bmj-2023-074787","article-title":"Promoting activity, independence, and stability in early dementia and mild cognitive impairment (PrAISED): randomised controlled trial","volume":"382","author":"Harwood","year":"2023","journal-title":"BMJ"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1614962","DOI":"10.3389\/fnagi.2025.1614962","article-title":"Biological determinants of blood-based biomarker levels in Alzheimer\u2019s disease: role of nutrition, inflammation, and metabolic 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Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1886820\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T04:22:49Z","timestamp":1780892569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1886820\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":38,"alternative-id":["10.3389\/fnut.2026.1886820"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1886820","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"article-number":"1886820"}}