{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T06:28:14Z","timestamp":1787120894632,"version":"build-2736575974"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of malnutrition is relatively high among patients with chronic obstructive pulmonary disease (COPD). The main objective of this study was to explore and compare the discriminative ability of phase angle (PhA) and geriatric nutritional risk index (GNRI) tools for assessing malnutrition among hospitalized patients with COPD who underwent BIA assessment and had available serum albumin data based on the GLIM criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center retrospective study included 121 patients with hospitalized COPD with BIA measurement and valid serum albumin. All patients underwent body composition analysis and biochemical measurements. Based on the global leadership initiative on malnutrition (GLIM) criteria, patients were categorized into COPD patients with malnutrition and COPD patients without malnutrition. Bootstrap resampling with 1,000 iterations and Hosmer-Lemeshow test evaluate the stability and reliability of the two tools and malnutrition in COPD. More importantly, the exploratory diagnostic efficacies and net clinical benefit of PhA and GNRI tools were assessed for identifying COPD patients with malnutrition using ROC, DeLong test, Decision-curve analysis (DCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Using the GLIM malnutrition criteria as the reference, a diagnostic efficacy analysis was conducted using the preset cutoff values of PhA\u202f=\u202f4.25\u00b0 and GNRI\u202f=\u202f98. The sensitivity of PhA was 0.691, the specificity was 0.625, the accuracy was 0.669, and the K value was 0.298. The sensitivity, specificity, accuracy and K value were 0.753, 0.700, 0.736 and 0.431 for GNRI. The ROC results showed that the AUC of PhA and GNRI were 0.656 (95% CI: 0.543\u202f~\u202f0.769) and 0.785 (95% CI: 0.699\u202f~\u202f0.870), respectively. The DeLong test indicated that there was a statistically significant difference in the AUC between the two tools (\n                      <jats:italic>p<\/jats:italic>\n                      =\u202f0.035). DCA showed that net clinical benefits of the two tools were similar at low thresholds. As the threshold increased, the net clinical benefit of PhA decreased rapidly and turned negative, while GNRI maintained a positive net clinical benefit in a wider threshold range.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GNRI and PhA showed differing discriminative profiles for GLIM-defined malnutrition. The valid threshold range differed between the two tools. GNRI yielded net clinical benefit over a wider threshold span, while positive net clinical benefit for PhA was restricted to low-risk thresholds.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1887430","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T05:49:05Z","timestamp":1787118545000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic value of geriatric nutritional risk index and phase angle for malnutrition in patients with COPD: a retrospective cohort study"],"prefix":"10.3389","volume":"13","author":[{"given":"Xinxin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, The First Affiliated Hospital of Henan University","place":["Kaifeng, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaying","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, The First Affiliated Hospital of Henan University","place":["Kaifeng, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Henan University","place":["Kaifeng, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuangjian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, The First Affiliated Hospital of Henan University","place":["Kaifeng, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyue","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Public Health, Hebi City Center for Disease Control and Prevention","place":["Hebi, Henan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1404615","DOI":"10.3389\/fimmu.2024.1404615","article-title":"Inflammation mechanism and research progress of COPD","volume":"15","author":"Xu","year":"2024","journal-title":"Front Immunol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"434","DOI":"10.3238\/arztebl.m2023.027","article-title":"The diagnosis and treatment of COPD and its comorbidities","volume":"120","author":"Kahnert","year":"2023","journal-title":"Dtsch Arztebl Int"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/s2213-2600(17)30293-x","article-title":"Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990-2015: a systematic analysis for the global burden of disease study 2015","volume":"5","year":"1990","journal-title":"Lancet Respir Med"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1002\/ncp.10306","article-title":"Nutrition status and chronic obstructive pulmonary disease: can we move beyond the body mass index?","volume":"34","author":"Raad","year":"2019","journal-title":"Nutr Clin Pract"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s12020-018-1533-4","article-title":"Body composition and sarcopenia in patients with chronic obstructive pulmonary disease","volume":"60","author":"Munhoz da Rocha Lemos Costa","year":"2018","journal-title":"Endocrine"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1002\/jpen.2390","article-title":"Association of reduced BMI, length of hospital stay, mortality, and malnutrition diagnosis in patients with acute exacerbation COPD: a secondary analysis of a cohort study","volume":"47","author":"Bernardes","year":"2023","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"e001518","DOI":"10.3390\/nu14224746","article-title":"Validation of Asian body mass index cutoff values for the classification of malnutrition severity according to the global leadership initiative on malnutrition criteria in patients with chronic obstructive pulmonary disease exacerbations","volume":"14","author":"Shirai","year":"2022","journal-title":"Nutrients"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1775","DOI":"10.1002\/jcsm.13256","article-title":"Low muscle mass, malnutrition, sarcopenia, and associations with survival in adults with cancer in the UK biobank cohort","volume":"14","author":"Kiss","year":"2023","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1007\/s11845-020-02403-3","article-title":"How reliable is BMI? 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