{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:25:55Z","timestamp":1786123555655,"version":"build-2736575974"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Numerous epidemiological studies have suggested a potential association between the antioxidant capacity of the diet and the risk of breast cancer. Yet, these studies have yielded inconclusive results. We therefore conducted a systematic review and dose-response meta-analysis of observational studies to ascertain the association between dietary total antioxidant capacity (TAC) and breast cancer risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We systematically searched PubMed, Embase, Scopus, ISI Web of Science and China National Knowledge Infrastructure (CNKI) from database inception to May 2026, using predefined keywords to identify the relevant articles. Random-effects or fixed-effects models were used to pool relative risks (RRs) with corresponding 95% confidence intervals (CIs), as appropriate. Heterogeneity across studies was estimated using Cochran's Q test and the I\n                      <jats:sup>2<\/jats:sup>\n                      statistics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine observational studies (seven case-control and two cohort studies), encompassing 33,981 participants, were included in the meta-analysis. Higher dietary TAC intake was significantly associated with a lower risk of breast cancer (RR = 0.86; 95%CI: 0.76\u20130.98;\n                      <jats:italic>P<\/jats:italic>\n                      = 0.022). Conversely, each standard deviation increment in dietary TAC intake was not associated with the risk of breast cancer (RR = 0.98; 95%CI: 0.94\u20131.02,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.295). Also, the dose-response analysis showed a linear inverse association between dietary TAC and risk of breast cancer (RR = 0.988; 95%CI: 0.981\u20130.995,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>dose<\/jats:italic>\n                        \u2212\n                        <jats:italic>response<\/jats:italic>\n                      <\/jats:sub>\n                      =0.001,\n                      <jats:italic>P<\/jats:italic>\n                      <jats:sub>\n                        <jats:italic>nonlinearity<\/jats:italic>\n                      <\/jats:sub>\n                      = 0.546). The results of subgroup analyses showed a significant inverse association between dietary TAC and breast cancer in cohort studies, with low heterogeneity (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.174;\n                      <jats:italic>I<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      = 18.9%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study indicates that higher dietary TAC intake is associated with a reduced risk of breast cancer. Further well-designed longitudinal studies are warranted to confirm these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1890538","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:21:20Z","timestamp":1786116080000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dietary total antioxidant capacity and risk of breast cancer: a systematic review and dose-response meta-analysis of observational studies"],"prefix":"10.3389","volume":"13","author":[{"given":"Jianying","family":"Zhou","sequence":"first","affiliation":[{"name":"Healthcare Center, Zhejiang Hospital","place":["Hangzhou, Zhejiang Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Jin","sequence":"additional","affiliation":[{"name":"Healthcare Center, Zhejiang Hospital","place":["Hangzhou, Zhejiang Province, 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