{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:49:48Z","timestamp":1793213388040,"version":"4.5.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinical Trials from the Affiliated Drum Tower Hospital, Medical School of Nanjing University","award":["2022-LCYJ-ZX-09"],"award-info":[{"award-number":["2022-LCYJ-ZX-09"]}]},{"name":"Research Fund of Nanjing Drum Tower Hospital","award":["2022-LCYJ-PY-25"],"award-info":[{"award-number":["2022-LCYJ-PY-25"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Gastric and colorectal cancers have high postoperative recurrence despite curative surgery. Current preoperative nutritional assessments often do not fully integrate immune integration and objectivity. The primary objective was to explore preoperative HALP\u2014a composite metric of hemoglobin, albumin, lymphocyte, and platelet values\u2014and postoperative prognosis within the observed follow-up period in gastric and colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study enrolled patients with gastric or colorectal cancer (aged \u226518\u202fyears, stage I-III, without neoadjuvant therapy) between May 2021 and June 2022. Preoperative laboratory data within 24\u202fh of admission were collected, and HALP scores were calculated and dichotomized into low and high groups using the established cutoff of 16.81. Patients underwent quarterly postoperative follow-up until May 2025, with overall survival (OS) and progression-free survival (PFS) as endpoints, and statistical analyses included Kaplan\u2013Meier survival curves and Cox regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study cohort (median age 65\u202fyears; 66.8% male) included 75 gastric cancer patients (40.1%) and 112 colorectal cancer patients (59.9%), with 31 patients (16.6%) categorized in the low-HALP group. In both gastric and colorectal cancers, low-HALP patients had significantly inferior OS (log-rank\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0056 and 0.0117, respectively), with a non-significant trend toward worse PFS in both subgroups. Multivariable Cox regression confirmed HALP as an independent predictor of OS\/PFS (OS HR\u202f=\u202f0.138,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.000; PFS HR\u202f=\u202f0.415,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.009) in gastric and colorectal cancers. Critically, after TNM stage adjustment, Low-HALP remained associated with worse survival specifically in Stage III patients (both log-rank\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low preoperative HALP independently predicted poor prognosis in gastric and colorectal cancers during follow-up, particularly in Stage III disease, supporting its use as a complementary marker reflecting the synergistic cascade of malnutrition, inflammation, and immunosuppression linked to tumor aggressiveness.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1892588","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T04:16:18Z","timestamp":1787199378000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["The preoperative hemoglobin, albumin, lymphocyte, and platelet score as a prognostic Indicator for survival in gastric and colorectal cancer patients"],"prefix":"10.3389","volume":"13","author":[{"given":"Beijia","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxuan","family":"Chen","sequence":"additional","affiliation":[{"name":"The Affiliated Drum Tower Hospital Clinical College of Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Deng","sequence":"additional","affiliation":[{"name":"The Affiliated Drum Tower Hospital Clinical College of Xuzhou Medical University","place":["Xuzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School","place":["Nanjing, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,8,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J 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