{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:59:57Z","timestamp":1785214797590,"version":"3.55.0"},"reference-count":108,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>The Mediterranean diet (MedDiet) is widely recognized for its role in preventing chronic and age-related diseases, largely attributed to its richness in plant-based foods and bioactive compounds. To explore the underlying molecular mechanisms, two systematic literature searches were conducted using PubMed and Web of Science. The first assessed the evidence on the health effects of key MedDiet components and the second focused on plasma biomarkers of inflammation and oxidative stress. Protein-protein interaction network analysis revealed a tightly connected metabolic network integrating inflammatory mediators and metabolic regulators. Central nodes included key inflammatory markers such as interleukin-6, tumor necrosis factor and C-reactive protein (CRP), alongside proteins involved in lipid metabolism and metabolic homeostasis. Enrichment analysis highlighted pathways related to acute inflammatory response, lipid localization and storage and plasma lipoprotein particle clearance, supporting a role in regulation of immune and metabolic processes. An additional network integrating cardiovascular aging biomarkers suggested a partial separation between systemic inflammatory pathways and markers of myocardial stress and injury, with CRP emerging as a potential link between these processes. Overall, these findings indicate that the MedDiet may exert its health benefits through systems-level modulation of interconnected metabolic pathways, contributing to the regulation of inflammation, lipid metabolism and cardiovascular function.<\/jats:p>","DOI":"10.3389\/fnut.2026.1904329","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:25:33Z","timestamp":1785212733000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mediterranean diet impact on plasma proteins: biomarker networks linking nutrition to the modulation of inflammation and oxidative stress"],"prefix":"10.3389","volume":"13","author":[{"given":"F\u00e1tima","family":"Cardoso","sequence":"first","affiliation":[{"name":"UCIBIO Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa","place":["Caparica, Portugal"]},{"name":"Associate Laboratory i4HB Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa","place":["Caparica, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Costa-Camilo","sequence":"additional","affiliation":[{"name":"UCIBIO Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa","place":["Caparica, Portugal"]},{"name":"Associate Laboratory i4HB Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa","place":["Caparica, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Duarte","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Investiga\u00e7\u00e3o Agr\u00e1ria e Veterin\u00e1ria (INIAV)","place":["Elvas, Portugal"]},{"name":"GeoBioTec, NOVA School of Science and Technology (NOVA FCT), Universidade NOVA de Lisboa","place":["Caparica, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gra\u00e7a P.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Bioscience School of Elvas, Portalegre Polytechnic University","place":["Elvas, Portugal"]},{"name":"Research Center for Endogenous Resource Valorization (VALORIZA)","place":["Portalegre, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita G.","family":"Sobral","sequence":"additional","affiliation":[{"name":"UCIBIO Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa","place":["Caparica, Portugal"]},{"name":"Associate Laboratory i4HB Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa","place":["Caparica, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o M. G. C. F. de","family":"Almeida","sequence":"additional","affiliation":[{"name":"UCIBIO Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa","place":["Caparica, Portugal"]},{"name":"Associate Laboratory i4HB Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa","place":["Caparica, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"UCIBIO Applied Molecular Biosciences Unit, Department of Life Sciences, NOVA School of Science and Technology, Universidade NOVA de Lisboa","place":["Caparica, Portugal"]},{"name":"Associate Laboratory i4HB Institute for Health and Bioeconomy, NOVA School of Science and Technology, Universidade NOVA de Lisboa","place":["Caparica, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.3390\/molecules26123483","article-title":"Polyphenols of the Mediterranean diet and their metabolites in the prevention of colorectal cancer","volume":"26","author":"Yammine","year":"2021","journal-title":"Molecules"},{"key":"B2","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.pcad.2015.04.003","article-title":"Benefits of the Mediterranean diet: insights from the PREDIMED study","volume":"58","author":"Mart\u00ednez-Gonz\u00e1lez","year":"2015","journal-title":"Progr Cardiovascul Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"6723931","DOI":"10.1155\/2017\/6723931","article-title":"Dietary polyphenols, Mediterranean diet, prediabetes, and type 2 diabetes: a narrative review of the evidence","volume":"2017","author":"Guasch-Ferr\u00e9","year":"2017","journal-title":"Oxid Med Cell Longev."},{"key":"B4","doi-asserted-by":"publisher","first-page":"5807","DOI":"10.1002\/jcp.27506","article-title":"Metabolic syndrome, Mediterranean diet, and polyphenols: evidence and perspectives","volume":"234","author":"Finicelli","year":"2019","journal-title":"J Cell Physiol."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5297.218","article-title":"Cancer chemopreventive activity of resveratrol, a natural product derived from grapes","author":"Jang","year":"1997","journal-title":"Science"},{"key":"B6","doi-asserted-by":"publisher","first-page":"4716","DOI":"10.3390\/ijms20194716","article-title":"Metabolic and vascular effect of the Mediterranean diet","volume":"20","author":"Tuttolomondo","year":"2019","journal-title":"Internat J Mol Sci"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/61.6.1402S","article-title":"Mediterranean diet pyramid: a cultural model for healthy eating","author":"Willett","year":"1995","journal-title":"Am J Clin Nutr."},{"key":"B8","unstructured":"Paris\n          UNESCO\n          The Mediterranean Diet. Intangible Heritage.\n          \n          2010"},{"key":"B9","doi-asserted-by":"publisher","first-page":"e73087","DOI":"10.1371\/journal.pone.0073087","article-title":"Plasma proteome profiles associated with diet-induced metabolic syndrome and the early onset of metabolic syndrome in a pig model","volume":"8","author":"Pas","year":"2013","journal-title":"PLoS ONE."},{"key":"B10","unstructured":"FIM rationale and proposed guidelines for the Nutraceutical Research and Education Act\u2013NREA"},{"key":"B11","article-title":"Vegetables as a potential source of nutraceuticals and phytochemicals: a review","author":"Singh","year":"2015","journal-title":"Int J Med Pharm Sci."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.024261","article-title":"Plasma ceramides, Mediterranean diet, and incident cardiovascular disease in the PREDIMED trial (Prevenci\u00f3n con Dieta Mediterr\u00e1nea)","author":"Wang","year":"2017","journal-title":"Circulation"},{"key":"B13","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1161\/CIRCULATIONAHA.113.006921","article-title":"Extra-virgin olive oil consumption reduces risk of atrial fibrillation: the PREDIMED (Prevenci\u00f3n con Dieta Mediterr\u00e1nea) trial","volume":"130","author":"Mart\u00ednez-Gonz\u00e1lez","year":"2014","journal-title":"Circulation."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980007668499","article-title":"Evaluating associations between Mediterranean diet adherence indexes and biomarkers of diet and disease","author":"Bach-Faig","year":"2006","journal-title":"Public Health Nutr."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-103640","article-title":"Physical inactivity and non-communicable disease burden in low-income, middle-income and high-income countries","author":"Katzmarzyk","year":"2022","journal-title":"British J Sport Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.trstmh.2005.07.021","article-title":"The double burden of communicable and non-communicable diseases in developing countries","volume":"100","author":"Boutayeb","year":"2006","journal-title":"Trans R Soc Trop Med Hyg."},{"key":"B17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/978-3-030-10616-4_4","article-title":"Early life nutrition and non-communicable disease","author":"Heidari-Beni","year":"2019","journal-title":"Primordial Prevention of Non-Communicable Disease"},{"key":"B18","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s41649-020-00112-8","article-title":"Why have non-communicable diseases been left behind?","volume":"12","author":"Luna","year":"2020","journal-title":"Asian Bioethic Rev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1659","DOI":"10.1016\/S0140-6736(16)31679-8","article-title":"Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990\u20132015: a systematic analysis for the global burden of disease study 2015","volume":"388","author":"GBD","year":"2016","journal-title":"Lancet"},{"key":"B21","unstructured":"European\n              Commission\n            \n          \n          Non-Communicable Diseases"},{"key":"B22","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1186\/s12939-023-01958-8","article-title":"Inequalities in the burden of non-communicable diseases across European countries: a systematic analysis of the Global Burden of Disease 2019 study","volume":"22","author":"Andrade","year":"2023","journal-title":"Int J Equity Health"},{"key":"B23","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1093\/eurpub\/ckab218","article-title":"Burden of non-communicable disease studies in Europe: a systematic review of data sources and methodological choices","volume":"32","author":"Charalampous","year":"2022","journal-title":"Eur J Public Health"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1017\/S000711452000344X","article-title":"Consumption of ultra-processed foods and non-communicable disease-related nutrient profile in Portuguese adults and elderly (2015\u20132016): the UPPER project","volume":"125","author":"Miranda","year":"2021","journal-title":"British J Nutr."},{"key":"B25","doi-asserted-by":"publisher","first-page":"17","DOI":"10.3390\/gastronomy3040017","article-title":"Mediterranean Diet as a nutraceutical and sustainable model for health and environmental wellbeing","volume":"3","author":"Costa-Camilo","year":"2025","journal-title":"Gastronomy."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3037","DOI":"10.1182\/blood-2013-12-541672","article-title":"Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Molisani study","volume":"123","author":"Bonaccio","year":"2014","journal-title":"Blood, J Am Soc Hematol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3945\/ajcn.2008.26094","article-title":"Inhibition of circulating immune cell activation: a molecular anti: inflammatory effect of the Mediterranean diet","volume":"89","author":"Mena","year":"2009","journal-title":"Am J Clin Nutr"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1038\/s41396-018-0068-2","article-title":"Elevated circulating levels of succinate in human obesity are linked to specific gut microbiota","volume":"12","author":"Serena","year":"2018","journal-title":"ISME J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1089\/jwh.2012.3707","article-title":"A comparison of Mediterranean: style and MyPyramid diets on weight loss and inflammatory biomarkers in postpartum breastfeeding women","volume":"22","author":"Stendell-Hollis","year":"2013","journal-title":"J Women's Health"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1093\/ajcn\/nqy207","article-title":"A Mediterranean diet supplemented with dairy foods improves markers of cardiovascular risk: results from the MedDairy randomized controlled trial","volume":"108","author":"Wade","year":"2018","journal-title":"Am J Clin Nutr."},{"key":"B31","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.nutres.2009.03.001","article-title":"A Mediterranean dietary intervention in healthy American women changes plasma carotenoids and fatty acids in distinct clusters","volume":"29","author":"Djuric","year":"2009","journal-title":"Nutr Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1882","DOI":"10.3390\/medicina59101882","article-title":"A Mediterranean-style diet improves the parameters for the management and prevention of type 2 diabetes mellitus","volume":"59","author":"Derrick","year":"2023","journal-title":"Medicina"},{"key":"B33","doi-asserted-by":"publisher","first-page":"995","DOI":"10.3390\/antiox13080995","article-title":"A randomised, double-blind, placebo-controlled, cross-over clinical trial to evaluate the biological effects and safety of a polyphenol supplement on healthy ageing","volume":"13","author":"Chong","year":"2024","journal-title":"Antioxidants"},{"key":"B34","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/j.jadohealth.2017.09.012","article-title":"Ability of nontraditional risk factors and inflammatory biomarkers for cardiovascular disease to identify high cardiometabolic risk in adolescents: results from the LabMed physical activity study","volume":"62","author":"Agostinis-Sobrinho","year":"2018","journal-title":"J Adol Health"},{"key":"B35","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.numecd.2006.08.009","article-title":"Adherence to a healthful life attenuates lipid parameters among a healthy Italian population","volume":"17","author":"Sofi","year":"2007","journal-title":"Nutr Metabol Cardiovascul Dis."},{"key":"B36","doi-asserted-by":"publisher","first-page":"2014","DOI":"10.1016\/j.numecd.2021.04.006","article-title":"Adherence to a Mediterranean diet, dyslipidemia and inflammation in familial hypercholesterolemia","volume":"31","author":"Antoniazzi","year":"2021","journal-title":"Nutr Metabol Cardiovascul Dis"},{"key":"B37","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1186\/s12916-021-02154-7","article-title":"Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study","volume":"19","author":"Hidalgo-Liberona","year":"2021","journal-title":"BMC Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jacc.2004.03.039","article-title":"Adherence to the Mediterranean diet attenuates inflammation and coagulation process in healthy adults: the ATTICA study","volume":"44","author":"Chrysohoou","year":"2004","journal-title":"J Am Coll Cardiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"117L169","DOI":"10.1161\/CIRCULATIONAHA.107.710699","article-title":"Adherence to the Mediterranean diet is inversely associated with circulating interleukin: 6 among middle-aged men: a twin study","author":"Dai","year":"2008","journal-title":"Circulation"},{"key":"B40","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1159\/000371570","article-title":"Anti-inflammatory effect of white wine in CKD patients and healthy volunteers","volume":"41","author":"Migliori","year":"2015","journal-title":"Am J Nephrol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"3674390","DOI":"10.1155\/2017\/3674390","article-title":"Anti-inflammatory effects of the Mediterranean diet in the early and late stages of atheroma plaque development","volume":"2017","author":"Casas","year":"2017","journal-title":"Mediat Infla"},{"key":"B42","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3390\/metabo9100201","article-title":"Application of 1H-NMR metabolomics for the discovery of blood plasma biomarkers of a Mediterranean diet","volume":"9","author":"Macias","year":"2019","journal-title":"Metabolites."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.3390\/nu11092250","article-title":"Assessing validity of self-reported dietary intake within a Mediterranean diet cluster randomized controlled trial among US firefighters","volume":"11","author":"Sotos-Prieto","year":"2019","journal-title":"Nutrients."},{"key":"B44","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1475-2840-12-7","article-title":"Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk","volume":"12","author":"Juanola-Falgarona","year":"2013","journal-title":"Cardiovasc Diabetol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/j.numecd.2010.03.005","article-title":"Can the Mediterranean diet lower HbA1c in type 2 diabetes? Results from a randomized cross-over study","volume":"21","author":"Itsiopoulos","year":"2010","journal-title":"Nutr Metabol Cardiovascul Dis."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1017\/S0007114516003056","article-title":"Carotenoids as biomarkers of fruit and vegetable intake in men and women","volume":"116","author":"Couillard","year":"2016","journal-title":"British J Nutr."},{"key":"B47","doi-asserted-by":"publisher","first-page":"129","DOI":"10.30802\/AALAS-CM-17-000099","article-title":"Changes in plasma protein expression indicative of early diet-induced metabolic disease in male pigs (Sus scrofa)","volume":"68","author":"Pas","year":"2018","journal-title":"Comparativ Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"113028","DOI":"10.1016\/j.biopha.2022.113028","article-title":"Changes in plasma total saturated fatty acids and palmitic acids are related to pro: inflammatory molecule IL:6 concentrations after nutritional intervention for one year","volume":"150","author":"Dom\u00ednguez-L\u00f3pez","year":"2022","journal-title":"Biomed Pharmacother."},{"key":"B49","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1017\/S0007114508888708","article-title":"Chronic effects of a high-fat diet enriched with virgin olive oil and a low-fat diet enriched with \u03b1-linolenic acid on postprandial endothelial function in healthy men","volume":"100","author":"Fuentes","year":"2008","journal-title":"British J Nutr"},{"key":"B50","doi-asserted-by":"publisher","first-page":"967967","DOI":"10.3389\/fnut.2022.967967","article-title":"Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk","volume":"9","author":"Marhuend-Mu\u00f1oz","year":"2022","journal-title":"Front Nutr."},{"key":"B51","doi-asserted-by":"publisher","first-page":"S66","DOI":"10.1038\/sj.ejcn.1601819","article-title":"Changes in the immune system are conditioned by nutrition","volume":"57","author":"Marcos","year":"2003","journal-title":"Eur J Clin Nutr."},{"key":"B52","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.foodres.2015.10.017","article-title":"The role of polyphenols on bone metabolism in osteoporosis","volume":"77","author":"\u00d0*udari\u0107","year":"2015","journal-title":"Food Res Int."},{"key":"B53","doi-asserted-by":"publisher","first-page":"794","DOI":"10.5114\/aoms.2012.31614","article-title":"Impact of physical activity on inflammation: effects on cardiovascular disease risk and other inflammatory conditions","volume":"8","author":"Ertek","year":"2012","journal-title":"Arch Med Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1016\/j.numecd.2010.12.006","article-title":"Crossover study of diets enriched with virgin olive oil, walnuts or almonds: effects on lipids and other cardiovascular risk markers","volume":"21","author":"Damasceno","year":"2011","journal-title":"Nutr Metabol Cardiovascul Dis."},{"key":"B55","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1017\/S1368980009990231","article-title":"Diet quality of a population sample from coastal north-east Spain evaluated by a Mediterranean adaptation of the diet quality index (DQI)","volume":"13","author":"Bondia-Pons","year":"2010","journal-title":"Public Health Nutr."},{"key":"B56","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1177\/0003319707300014","article-title":"Diet, exercise, and C-reactive protein levels in people with abdominal obesity: the ATTICA epidemiological study","volume":"58","author":"Pitsavos","year":"2007","journal-title":"Angiology."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1209787","DOI":"10.3389\/fnut.2023.1209787","article-title":"Dietary biomarkers and food records indicate compliance to study diets in the ADIRA (anti-inflammatory diet in rheumatoid arthritis) trial","volume":"10","author":"Wadell","year":"2023","journal-title":"Front Nutr."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1038\/ejcn.2013.196","article-title":"Dietary factors associated with subclinical inflammation among girls","volume":"67","author":"Bibiloni","year":"2013","journal-title":"Eur J Clin Nutr."},{"key":"B59","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.numecd.2011.09.009","article-title":"Dietary glycemic index\/load and peripheral adipokines and inflammatory markers in elderly subjects at high cardiovascular risk","volume":"23","author":"Bull\u00f3","year":"2013","journal-title":"Nutr Metabol Cardiovascul Dis."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102932","article-title":"Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: an IMI DIRECT study","author":"Eriksen","year":"2020","journal-title":"EBioMedicine"},{"key":"B61","doi-asserted-by":"publisher","first-page":"689","DOI":"10.3390\/nu12030689","article-title":"Dietary polyphenol intake is associated with HDL-cholesterol and a better profile of other components of the metabolic syndrome: a PREDIMED: plus sub-study","volume":"12","author":"Castro-Barquero","year":"2020","journal-title":"Nutrients."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1038\/s41380-023-01975-7","article-title":"Plasma proteins related to inflammatory diet predict future cognitive impairment","volume":"28","author":"Duggan","year":"2023","journal-title":"Molecul Psychiatr."},{"key":"B63","doi-asserted-by":"publisher","first-page":"833","DOI":"10.3390\/antiox12040833","article-title":"Mediterranean diet improves plasma biomarkers related to oxidative stress and inflammatory process in patients with non-alcoholic fatty liver disease","volume":"12","author":"Quetglas-Llabr\u00e9s","year":"2023","journal-title":"Antioxidants."},{"key":"B64","doi-asserted-by":"publisher","first-page":"901","DOI":"10.3390\/antiox11050901","article-title":"Inflammatory and oxidative stress markers related to adherence to the Mediterranean diet in patients with metabolic syndrome","volume":"11","author":"Quetglas-Llabr\u00e9s","year":"2022","journal-title":"Antioxidants."},{"key":"B65","article-title":"Evaluation of the human plasma antioxidant capacity influenced by the Mediterranean diet","author":"Rocha","year":"2026","journal-title":"Experiment Finding."},{"key":"B66","doi-asserted-by":"publisher","first-page":"754","DOI":"10.3390\/antiox13070754","article-title":"Effects of a two-year lifestyle intervention on intrahepatic fat reduction and renal health: mitigation of inflammation and oxidative stress, a randomized trial","volume":"13","author":"Quetglas-Llabr\u00e9s","year":"2024","journal-title":"Antioxidants."},{"key":"B67","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1108\/NFS-07-2023-0140","article-title":"Mediterranean diet and telomere length: aspects from obesity","volume":"54","author":"Arslan","year":"2024","journal-title":"Nutr Food Sci"},{"key":"B68","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.advnut.2024.100219","article-title":"Diet, food, nutritional exposures and inflammatory bowel disease or progression of disease: an umbrella review","volume":"15","author":"Christensen","year":"2024","journal-title":"Adv Nutr."},{"key":"B69","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1080\/09637486.2023.2276033","article-title":"Greater fruit and vegetables consumption, and adherence to a Mediterranean type of diet reduces the risk for asthma in children: a systematic review and meta-analysis","volume":"75","author":"Antonogeorgos","year":"2024","journal-title":"Int J Food Sci Nutr"},{"key":"B70","doi-asserted-by":"publisher","first-page":"1383040","DOI":"10.3389\/fnut.2024.1383040","article-title":"Unraveling the intricate dance of the Mediterranean diet and gut microbiota in autoimmune resilience","volume":"11","author":"Tsigalou","year":"2024","journal-title":"Front Nutr."},{"key":"B71","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"B72","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0021-9150(03)00243-0","article-title":"Effect of a nutritional intervention promoting the Mediterranean food pattern on plasma lipids, lipoproteins and body weight in healthy French-Canadian women","volume":"170","author":"Goulet","year":"2003","journal-title":"Atherosclerosis."},{"key":"B73","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.cardiores.2004.12.027","article-title":"Endothelial aging","volume":"66","author":"Brandes","year":"2005","journal-title":"Cardiovasc Res."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7326\/0003-4819-145-1-200607040-00004","article-title":"Effects of a Mediterranean-style diet on cardiovascular risk factors: a randomized trial","volume":"145","author":"Estruch","year":"2006","journal-title":"Annal Int Med"},{"key":"B75","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/app14104203","article-title":"Narrative review of metabolomic insights into olive oil's nutritional value","author":"Gon\u00e7alves","year":"2024","journal-title":"Appl Sci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3390\/biom14060722","article-title":"Comprehensive review of Olea europaea: a holistic exploration into its botanical marvels, phytochemical riches, therapeutic potentials, and safety profile","author":"Elhrech","year":"2024","journal-title":"Biomolecules."},{"key":"B77","doi-asserted-by":"publisher","first-page":"108595","DOI":"10.1016\/j.pharmthera.2024.108595","article-title":"Olea europaea L-derived secoiridoids: beneficial health effects and potential therapeutic approaches","volume":"254","author":"Filardo","year":"2024","journal-title":"Pharmacol Ther."},{"key":"B78","doi-asserted-by":"publisher","first-page":"4942","DOI":"10.3390\/ijms25094942","article-title":"The Mediterranean diet, its microbiome connections, and cardiovascular health: a narrative review","volume":"25","author":"Abrignani","year":"2024","journal-title":"Int J Mol Sci."},{"key":"B79","doi-asserted-by":"publisher","first-page":"8117","DOI":"10.3390\/ijms25158117","article-title":"Extra virgin olive oil and metabolic diseases","volume":"25","author":"Tsimihodimos","year":"2024","journal-title":"Int J Mol Sci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.3390\/foods13162619","article-title":"Health outcomes associated with olive oil intake: an umbrella review of meta-analyses","volume":"13","author":"Chiavarini","year":"2024","journal-title":"Foods."},{"key":"B81","doi-asserted-by":"publisher","first-page":"4258","DOI":"10.3390\/nu16244258","article-title":"Resveratrol and extra virgin olive oil: protective agents against age-related disease","volume":"16","author":"Morkovin","year":"2024","journal-title":"Nutrients."},{"key":"B82","doi-asserted-by":"publisher","first-page":"452","DOI":"10.20452\/pamw.16708","article-title":"Alcohol, health loss, and mortality: can wine really save the good name of moderate alcohol consumption?","volume":"134","author":"Surma","year":"2024","journal-title":"Polish Arch Int Med."},{"key":"B83","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1080\/10408398.2023.2248506","article-title":"Endothelial progenitor cells as an emerging cardiovascular risk factor in the field of food and nutrition research: advances and challenges","volume":"64","author":"Xia XJ Li","year":"2024","journal-title":"Crit Rev Food Sci Nutr."},{"key":"B84","doi-asserted-by":"publisher","first-page":"3431","DOI":"10.3390\/nu16203431","article-title":"The potential effects of red wine and its components on neurocognitive disorders: a narrative review","volume":"16","author":"Boccardi","year":"2024","journal-title":"Nutrients."},{"key":"B85","doi-asserted-by":"publisher","first-page":"9796","DOI":"10.3390\/ijms25189796","article-title":"Wine, polyphenols, and the matrix effect: is alcohol always the same?","volume":"25","author":"Miraldi","year":"2024","journal-title":"Int J Mol Sci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"756","DOI":"10.3390\/nu16060756","article-title":"Effect of aromatic herbs and spices present in the Mediterranean diet on the glycemic profile in type 2 diabetes subjects: a systematic review and meta-analysis","volume":"16","author":"Garza","year":"2024","journal-title":"Nutrients."},{"key":"B87","first-page":"1093","article-title":"Overview of anti-inflammatory diets and their promising effects on non-communicable diseases","volume":"131","author":"Yu","year":"2024","journal-title":"British J Nutr."},{"key":"B88","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1186\/s12967-024-05095-w","article-title":"Underrated aspects of a true Mediterranean diet: understanding traditional features for worldwide application of a \u201cPlaneterranean\u201d diet","volume":"22","author":"Godos","year":"2024","journal-title":"J Transl Med."},{"key":"B89","doi-asserted-by":"publisher","first-page":"2693","DOI":"10.1002\/jsf2.9610.1002\/jsf2.96","article-title":"Mediterranean herbs, spices, and medicinal plants: natural remedies and rich sources of bioactive compounds","volume":"103","author":"Trajkovska-Broach","year":"2023","journal-title":"J Sci Food Agricul"},{"key":"B90","doi-asserted-by":"publisher","first-page":"e61045","DOI":"10.7759\/cureus.61045","article-title":"A narrative review of the significance of popular diets in diabetes mellitus management","volume":"16","author":"Bayram","year":"2024","journal-title":"Cureus"},{"key":"B91","doi-asserted-by":"publisher","first-page":"e436","DOI":"10.1002\/edm2.436","article-title":"Human gut microbiome: therapeutic opportunities for metabolic syndrome-Hype or hope?","volume":"7","author":"Horvath","year":"2024","journal-title":"Endocrinol Diabet Metabol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1111\/nbu.12707","article-title":"Mediterranean diet for the management of metabolic dysfunction-associated steatotic liver disease in non-Mediterranean, Western countries: what's known and what's needed?","volume":"49","author":"Sualeheen","year":"2024","journal-title":"Nutr Bulletin"},{"key":"B93","doi-asserted-by":"publisher","first-page":"413","DOI":"10.3136\/fstr.FSTR-D-24-00024","article-title":"The potential effects of whole grain-enriched diet on preventing osteoporosis","volume":"30","author":"Zhang","year":"2024","journal-title":"Food Sci Technol Res"},{"key":"B94","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3390\/nu16010098","article-title":"Legumes: a vehicle for transition to sustainability","volume":"16","author":"Yanni","year":"2024","journal-title":"Nutrients."},{"key":"B95","doi-asserted-by":"publisher","first-page":"3081","DOI":"10.3390\/su16073081","article-title":"The role of legumes in the sustainable Mediterranean diet: analysis of the consumption of legumes in the Mediterranean population over the last ten years-A PRISMA statement methodology","volume":"16","author":"Carlini","year":"2024","journal-title":"Sustainability."},{"key":"B96","doi-asserted-by":"publisher","first-page":"4201","DOI":"10.3390\/nu16234201","article-title":"The key nutrients in the Mediterranean diet and their effects in inflammatory bowel disease: a narrative review","volume":"16","author":"Deleu","year":"2024","journal-title":"Nutrients"},{"key":"B97","doi-asserted-by":"publisher","first-page":"2683","DOI":"10.3390\/nu16162683","article-title":"From garden to pillow: understanding the relationship between plant-based nutrition and quality of sleep","volume":"16","author":"Arslan","year":"2024","journal-title":"Nutrients"},{"key":"B98","doi-asserted-by":"publisher","first-page":"34","DOI":"10.3390\/women4040034","article-title":"The importance of diet in the treatment of endometriosis","volume":"4","author":"Szczepanik","year":"2024","journal-title":"Women"},{"key":"B99","doi-asserted-by":"publisher","first-page":"2646","DOI":"10.3390\/nu16162646","article-title":"An anti-inflammatory diet and its potential benefit for individuals with mental disorders and neurodegenerative diseases-a narrative review","volume":"16","author":"van Zonneveld","year":"2024","journal-title":"Nutrients."},{"key":"B100","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.2174\/0118715303280097240130072031","article-title":"The recommendation of the Mediterranean-styled Japanese diet for healthy longevity","volume":"30","author":"Santa","year":"2024","journal-title":"Curr Pharm Des."},{"key":"B101","doi-asserted-by":"publisher","first-page":"632","DOI":"10.23736\/S0025-7826.23.04256-4","article-title":"Phytonutrients and weight control: the role of polyphenols","volume":"114","author":"Parisi","year":"2023","journal-title":"Minerva Med."},{"key":"B102","doi-asserted-by":"publisher","first-page":"4249","DOI":"10.1080\/10408398.2021.2025036","article-title":"Dietary determinants of healthy\/unhealthy metabolic phenotype in individuals with normal weight or overweight\/obesity: a systematic review","volume":"63","author":"Abiri","year":"2023","journal-title":"Crit Rev Food Sci Nutr."},{"key":"B103","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1080\/1028415X.2022.2073107","article-title":"The role of nutrition on Parkinson's disease: a systematic review","volume":"26","author":"Bianchi","year":"2023","journal-title":"Nutr Neurosci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1080\/10408398.2022.2158780","article-title":"Can habitual tea drinking be an effective approach against age-related neurodegenerative cognitive disorders? A systematic review and meta-analysis of epidemiological evidence","volume":"64","author":"Quan","year":"2024","journal-title":"Crit Rev Food Sci Nutr."},{"key":"B105","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.3390\/nu16152525","article-title":"The impact of the Mediterranean diet on telomere biology: implications for disease management\u2014a narrative review","volume":"16","author":"Baliou","year":"2024","journal-title":"Nutrients."},{"key":"B106","doi-asserted-by":"publisher","first-page":"10751","DOI":"10.3390\/ijms241310751","article-title":"Molecular aspects of a diet as a new pathway in the prevention and treatment of Alzheimer's disease","volume":"24","author":"Doroszkiewicz","year":"2023","journal-title":"Int J Mol Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1093\/nutrit\/nuad013","article-title":"Dietary pattern, food, and nutritional supplement effects on cognitive outcomes in mild cognitive impairment: a systematic review of previous reviews","volume":"81","author":"Andrews","year":"2023","journal-title":"Nutr Rev."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2023.2298098","article-title":"Potential of dietary polyphenols for protection from age: related decline and neurodegeneration: a role for gut microbiota?","author":"Ross","year":"2024","journal-title":"Nutr Neurosci"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1904329\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:25:36Z","timestamp":1785212736000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1904329\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":108,"alternative-id":["10.3389\/fnut.2026.1904329"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1904329","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]},"article-number":"1904329"}}