{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:02:01Z","timestamp":1784869321616,"version":"3.55.0"},"reference-count":101,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Maternal high-fat diet (mHFD) is a growing global nutritional concern during pregnancy. It induces maternal systemic low-grade inflammation and oxidative stress, reshaping the intrauterine milieu via the placenta and causing selective developmental impairments in offspring midbrain dopaminergic (DA) neurons\u2014including aberrant precursor proliferation\/differentiation, simplified synapses, and nigrostriatal circuit deficits\u2014which may increase adulthood Parkinson's disease (PD) susceptibility. Mechanistically, mHFD acts through two synergistic pathways: persistent activation of the insulin resistant\u2013NF-\u03baB inflammatory axis and suppression of PINK1\/Parkin-mediated mitophagy, mutually reinforcing and compromising DA neuron resilience. This article reviews the pathological process of mHFD-mediated remodeling of the intrauterine microenvironment to increase the susceptibility of offspring PD and its two core mechanism pathways: the continuous activation of the IR-NF-\u03baB inflammatory pathway and the functional inhibition of the PINK1\/Parkin-mediated mitophagy pathway. On this basis, multi-dimensional early warning markers based on inflammatory factors, mitophagy-related molecules, epigenetic markers and nutritional exposure indicators, as well as potential intervention strategies such as nutritional supplementation, anti-inflammatory and pro-mitophagy targeting the above pathways were summarized, in order to provide a theoretical reference for the primary prevention of PD.<\/jats:p>","DOI":"10.3389\/fnut.2026.1907443","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:22:50Z","timestamp":1784866970000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Research progress on the association of maternal high-fat diet with offspring neurodevelopment and susceptibility to Parkinson's disease"],"prefix":"10.3389","volume":"13","author":[{"given":"Qi","family":"Li","sequence":"first","affiliation":[{"name":"School of Basic Medical Sciences, Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Jia","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Inner Mongolia Medical University","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musi","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Palliative Care, Hohhot Hospital of Traditional Chinese Medicine and Mongolian Medicine","place":["Hohhot, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayaer","family":"Nashun","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Inner Mongolia Medical University","place":["Hohhot, 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