{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:16:57Z","timestamp":1788239817467,"version":"build-2803163510"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Continuous energy restriction may be associated with poor adherence and a risk of muscle mass loss in pediatric obesity management. This study evaluated the effects of a structured \u201c5\u202f+\u202f2\u201d dietary management model\u2014cycling 5 weekdays of calorie-restricted diet with 2 weekend days of high-protein diet\u2014supported by standardized supplements and professional supervision.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this prospective, non-randomized controlled trial conducted in Shenzhen, China, 84 children with persistent obesity (median age 11.1\u202fyears) were enrolled. The intervention group (\n                      <jats:italic>N<\/jats:italic>\n                      \u202f=\u202f31) followed an 8-week \u201c5\u202f+\u202f2\u201d protocol with dietitian-led behavioral guidance and satiety-enhancing supplements, followed by a 12-week follow-up period. Controls (\n                      <jats:italic>N<\/jats:italic>\n                      \u202f=\u202f53) received conventional weight-loss advice. Propensity score matching was employed to balance baseline cohorts (\n                      <jats:italic>N<\/jats:italic>\n                      \u202f=\u202f74; 30 intervention, 44 control). Changes in weight, body composition, metabolic parameters, and behavior were assessed at weeks 8 and 20.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At week 8, the intervention group achieved significantly greater weight loss (\u22121.42\u202f\u00b1\u202f1.73\u202fkg vs. \u22120.44\u202f\u00b1\u202f1.54\u202fkg,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.015) and body mass index (BMI) standard deviation score (SDS) reduction (\u22120.21\u202f\u00b1\u202f0.14 vs. -0.11\u202f\u00b1\u202f0.14,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.005) compared to controls. The median behavior score in the intervention group improved significantly from 66.0 to 82.0 (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), with marked increases in self-weighing frequency and physical activity. At the 20-week follow-up (post-summer break), the intervention group maintained greater reductions in body fat mass (\u22121.42\u202f\u00b1\u202f3.41 vs. +1.84\u202f\u00b1\u202f3.67\u202fkg,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001) and greater skeletal muscle gain (3.90\u202f\u00b1\u202f3.46 vs. 2.21\u202f\u00b1\u202f2.36\u202fkg,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.031) than the control group, with significantly lower fat mass index (FMI)\n                      <jats:italic>Z<\/jats:italic>\n                      -scores and higher muscle mass index (MMI)\n                      <jats:italic>Z<\/jats:italic>\n                      -scores. Linear regression identified boys (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.758,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.015), older children (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.240,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.003) and children with higher baseline adherence (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u202f=\u202f\u22120.356,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.004) as key predictors for BMI SDS reduction.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The \u201c5\u202f+\u202f2\u201d dietary management model was associated with favorable changes in body composition and health-related behaviors in children with obesity and may represent a practical dietary management strategy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1907795","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:26:55Z","timestamp":1788236815000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of a \u201c5\u202f+\u202f2\u201d dietary management model on body composition and behavioral modification in Chinese children with obesity: a prospective, non-randomized controlled trial"],"prefix":"10.3389","volume":"13","author":[{"given":"Huiping","family":"Su","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Shenzhen Children\u2019s Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shenzhen Children\u2019s Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfei","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shenzhen Children\u2019s Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chushan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shenzhen Children\u2019s Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shenzhen Children\u2019s Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shenzhen Children\u2019s Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Chronic Disease Prevention and Control, Shenzhen Center for Chronic Disease Control","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minlu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Child and Adolescent Chronic Disease Prevention and Control, Longgang District Chronic Disease Prevention and Control Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Shenzhen Children\u2019s Hospital","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"ref1","year":""},{"key":"ref2","doi-asserted-by":"publisher","first-page":"e035365","DOI":"10.1161\/JAHA.124.035365","article-title":"Childhood adiposity and risk of major clinical heart diseases in adulthood: a Mendelian randomization study","volume":"13","author":"Xiong","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e16825","DOI":"10.1097\/MD.0000000000016825","article-title":"Childhood obesity leads to adult type 2 diabetes and coronary artery diseases: a 2-sample Mendelian randomization study","volume":"98","author":"Fang","year":"2019","journal-title":"Medicine"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1038\/s41366-020-0523-9","article-title":"Birthweight, childhood overweight, height and growth and adult cancer risks: a review of studies using the Copenhagen school health records register","volume":"44","author":"Aarestrup","year":"2020","journal-title":"Int J Obes"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"e140065","DOI":"10.1172\/JCI140065","article-title":"Dietary interventions for obesity: clinical and mechanistic findings","volume":"131","author":"Chao","year":"2021","journal-title":"J Clin Invest"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"e13132","DOI":"10.1111\/obr.13132","article-title":"Dietetic management of obesity and severe obesity in children and adolescents: a scoping review of guidelines","volume":"22","author":"Alman","year":"2021","journal-title":"Obes Rev"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"450","DOI":"10.6133\/apjcn.202209_31(3).0013","article-title":"Guidelines for medical nutrition treatment of overweight\/obesity in China (2021)","volume":"31","year":"2021","journal-title":"Asia Pac J Clin Nutr"},{"key":"ref8","first-page":"90","article-title":"Chinese guidelines for the clinical management of obesity (2024 edition)","volume-title":"Med J PUMCH","year":"2025"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.3390\/nu16183125","article-title":"Efficacy, safety and acceptability of a very-low-energy diet in adolescents with obesity: a fast track to health sub-study","volume":"16","author":"Gow","year":"2024","journal-title":"Nutrients"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e12370","DOI":"10.1111\/cob.12370","article-title":"Low-carbohydrate interventions for adolescent obesity: nutritional adequacy and guidance for clinical practice","volume":"10","author":"Jebeile","year":"2020","journal-title":"Clin Obes"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"e12798","DOI":"10.1111\/ijpo.12798","article-title":"Novel dietary interventions for adolescents with obesity: a narrative review","volume":"16","author":"Hoare","year":"2021","journal-title":"Pediatr Obes"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1017\/S0954422416000238","article-title":"Nutrition, infection and stunting: the roles of deficiencies of individual nutrients and foods, and of inflammation, as determinants of reduced linear growth of children","volume":"30","author":"Millward","year":"2017","journal-title":"Nutr Res Rev"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1007\/s00394-024-03420-z","article-title":"Effect of a higher protein diet and lifestyle camp intervention on childhood obesity (the COPE study): results from a nonrandomized controlled trail with 52-weeks follow-up","volume":"63","author":"Jakobsen","year":"2024","journal-title":"Eur J Nutr"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"426","DOI":"10.3760\/cma.j.cn112140-20220124-00080","article-title":"Effects of high protein diet on anthropometric indices and blood lipid in overweight and obese children: a meta-analysis","volume":"60","author":"Jiang","year":"2022","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e13864","DOI":"10.1111\/obr.13864","article-title":"Umbrella review of systematic reviews to inform the development and translation of community-based childhood obesity prevention interventions","volume":"26","author":"Jacobs","year":"2025","journal-title":"Obes Rev"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"CD001871","DOI":"10.1002\/14651858.CD001871.pub4","article-title":"Interventions for preventing obesity in children","volume":"7","author":"Brown","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"24","DOI":"10.21037\/tp-2025-593","article-title":"The family-school-healthcare collaborative plan for childhood obesity: protocol for a cluster-sampled interventional study (the DREAM framework)","volume":"15","author":"Zhao","year":"2026","journal-title":"Transl Pediatr"},{"key":"ref18","volume-title":"Screening for Overweight and Obesity among School-age Children and Adolescents","year":"2018"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1186\/s12887-022-03618-2","article-title":"Association between dietary knowledge and overweight\/obesity in Chinese children and adolescents aged 8\u201318 years: a cross-sectional study","volume":"22","author":"Wang","year":"2022","journal-title":"BMC Pediatr"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1186\/s12889-021-10240-x","article-title":"Dietary patterns and their associations with overweight\/obesity among preschool children in Dongcheng District of Beijing: a cross-sectional study","volume":"21","author":"Min","year":"2021","journal-title":"BMC Public Health"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3760\/cma.j.issn.0578-1310.2009.07.003","article-title":"Height and weight standardized growth charts for Chinese children and adolescents aged 0 to 18 years","volume":"47","author":"Li","year":"2009","journal-title":"Zhonghua Er Ke Za Zhi [Chin. J. Pediatrics]"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"493","DOI":"10.3760\/cma.j.issn.0578-1310.2009.07.004","article-title":"Body mass index growth curves for Chinese children and adolescents aged 0 to 18 years","volume":"47","author":"Li","year":"2009","journal-title":"Zhonghua Er Ke Za Zhi [Chinese Journal of Pediatrics]"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"e214375","DOI":"10.1001\/jamapediatrics.2021.4375","article-title":"Effectiveness of a multifaceted intervention for prevention of obesity in primary school children in China: a cluster randomized clinical trial","volume":"176","author":"Liu","year":"2022","journal-title":"JAMA Pediatr"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1007\/s11154-020-09576-3","article-title":"The role of dietary protein in obesity","volume":"21","author":"Magkos","year":"2020","journal-title":"Rev Endocr Metab Disord"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3560","DOI":"10.3390\/nu16203560","article-title":"Proteins and peptides from food sources with effect on satiety and their role as anti-obesity agents: a narrative review","volume":"16","author":"Ignot-Guti\u00e9rrez","year":"2024","journal-title":"Nutrients"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.3945\/ajcn.112.044321","article-title":"Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials","volume":"96","author":"Wycherley","year":"2012","journal-title":"Am J Clin Nutr"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.3390\/nu13072473","article-title":"Weight loss strategies and the risk of skeletal muscle mass loss","volume":"13","author":"McCarthy","year":"2021","journal-title":"Nutrients"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"20220449","DOI":"10.1098\/rstb.2022.0449","article-title":"Diet composition and energy intake in humans","volume":"378","author":"Stubbs","year":"2023","journal-title":"Philos Trans R Soc Lond Ser B Biol Sci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"161","DOI":"10.7570\/jomes22031","article-title":"Nutrient-based appetite regulation","volume":"31","author":"Moris","year":"2022","journal-title":"J Obes Metab Syndr"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"95","DOI":"10.15171\/jcvtr.2018.15","article-title":"High protein diets do not affect anthropometric indexes and cardiometabolic risk factors among children with excess weight: a randomized controlled trial","volume":"103","author":"Izadi","year":"2018","journal-title":"J Cardiovasc Thorac Res"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3945\/ajcn.112.042630","article-title":"Effects of a low glycemic load or a low-fat dietary intervention on body weight in obese Hispanic American children and adolescents: a randomized controlled trial","volume":"97","author":"Mirza","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"e0151787","DOI":"10.1371\/journal.pone.0151787","article-title":"A randomized controlled trial of two different macronutrient profiles on weight, body composition and metabolic parameters in obese adolescents seeking weight loss","volume":"11","author":"Truby","year":"2016","journal-title":"PLoS One"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1001\/jamapediatrics.2024.2869","article-title":"Intermittent energy restriction for adolescents with obesity: the fast track to health randomized clinical trial","volume":"178","author":"Lister","year":"2024","journal-title":"JAMA Pediatr"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1093\/jn\/nxz049","article-title":"Intermittent energy restriction is a feasible, effective, and acceptable intervention to treat adolescents with obesity","volume":"149","author":"Jebeile","year":"2019","journal-title":"J Nutr"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.ejim.2021.01.019","article-title":"Patient motivation to lose weight: importance of healthcare professional support, goals and self-efficacy","volume":"91","author":"Dicker","year":"2021","journal-title":"Eur J Intern Med"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.3390\/nu13041200","article-title":"Management of childhood obesity \u2013 time to shift from generalized to personalized intervention strategies","volume":"13","author":"Motevalli","year":"2021","journal-title":"Nutrients"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1093\/jpepsy\/jsu023","article-title":"Systematic review and meta-analysis of comprehensive behavioral family lifestyle interventions addressing pediatric obesity","volume":"39","author":"Janicke","year":"2014","journal-title":"J Pediatr Psychol"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1907795\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T04:26:59Z","timestamp":1788236819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1907795\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":37,"alternative-id":["10.3389\/fnut.2026.1907795"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1907795","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"article-number":"1907795"}}