{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T06:13:33Z","timestamp":1788416013482,"version":"build-2803163510"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This single-center retrospective cohort study included 2,221 patients with TBI admitted between March 29, 2018, and September 23, 2024. PANI was calculated as serum prealbumin (mg\/L) multiplied by albumin (g\/L) and was divided by 1,000 for analysis. The first available laboratory measurements after admission were used. The primary and secondary outcomes were all-cause in-hospital mortality and 7-day in-hospital mortality, respectively. Associations were assessed using Cox proportional hazards models. Discrimination was evaluated using receiver operating characteristic curves and pairwise comparisons of areas under the curve (AUCs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 2,221 patients, 78 (3.5%) died during hospitalization and 47 (2.1%) died in hospital within 7\u202fdays of admission. In the primary adjusted model (Model 3), each 1-unit increase in PANI\/1,000 was associated with lower hazards of in-hospital mortality (HR, 0.613; 95% CI, 0.560\u20130.671) and 7-day in-hospital mortality (HR, 0.640; 95% CI, 0.574\u20130.714). Corresponding HRs in the supplementary extended baseline model (Model 4) were 0.653 (95% CI, 0.593\u20130.720) and 0.690 (95% CI, 0.616\u20130.773), respectively. In the complete-case sensitivity analysis additionally incorporating body mass index and systolic blood pressure, the corresponding HRs were 0.562 (95% CI, 0.466\u20130.678) and 0.677 (95% CI, 0.528\u20130.870). PANI alone yielded AUCs of 0.856 (95% CI, 0.810\u20130.902) and 0.837 (95% CI, 0.774\u20130.901), respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Lower PANI was associated with higher in-hospital and 7-day in-hospital mortality in patients with TBI. However, the single-center design, potential selection bias, residual confounding, and absence of key neurological and imaging severity variables preclude conclusions regarding its clinical utility. The potential clinical value of PANI can only be evaluated after validation in multicenter prospective studies incorporating complete neurological and imaging assessments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1910413","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T05:22:47Z","timestamp":1788412967000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of the prealbumin\u2013albumin nutritional index with short-term mortality in hospitalized patients with traumatic brain injury"],"prefix":"10.3389","volume":"13","author":[{"given":"Hong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Affiliated Kunshan Hospital of Jiangsu University","place":["Kunshan, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaorong","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Affiliated Kunshan Hospital of Jiangsu University","place":["Kunshan, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Affiliated Kunshan Hospital of Jiangsu University","place":["Kunshan, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Affiliated Kunshan Hospital of Jiangsu University","place":["Kunshan, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyuan","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of Soochow University","place":["Suzhou, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3892\/etm.2025.12834","article-title":"Incidence and mortality related risk factors in patients with severe traumatic brain injury: a meta-analysis","volume":"29","author":"Liu","year":"2025","journal-title":"Exp Ther Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1016\/s1474-4422(17)30371-x","article-title":"Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research","volume":"16","author":"Maas","year":"2017","journal-title":"Lancet Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/s1474-4422(18)30469-1","article-title":"Traumatic brain injury in China","volume":"18","author":"Jiang","year":"2019","journal-title":"Lancet 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