{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T14:13:38Z","timestamp":1788358418035,"version":"build-2803163510"},"reference-count":105,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Late-life depression (LLD) represents a critical public health challenge, exerting a profound and detrimental impact on the health of older adults. Currently, dietary intervention is increasingly valued in the field of mental health. Various active components abundant in plant-based foods show great potential in preventing and alleviating depressive symptoms in the older adults. This narrative review aims to summarize the neuroprotective effects of major plant-derived bioactive compounds such as polyphenols, terpenoids and other components, which are related to LLD. It also listed alkaloids and polysaccharides as potential plant-derived bioactive compounds for LLD. It focuses on elucidating the research progress of their mechanisms and dietary patterns, thereby providing a theoretical basis for dietary intervention in treating older adults who are over 60 years old. Future trials should integrate multi-omics and quantitative evaluation to inform personalized LLD dietary interventions.<\/jats:p>","DOI":"10.3389\/fnut.2026.1913204","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:24:11Z","timestamp":1788355451000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Research progress on plant-derived bioactive compounds and late-life depression: from neuroprotective mechanisms to dietary patterns"],"prefix":"10.3389","volume":"13","author":[{"given":"Yao","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Psychiatry, First Hospital\/First Clinical Medical College of Shanxi Medical University","place":["Taiyuan, China"]},{"name":"Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorders, First Hospital of Shanxi Medical University","place":["Taiyuan, 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