{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T05:18:43Z","timestamp":1787635123423,"version":"build-2736575974"},"reference-count":57,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High-fat diet (HFD)-induced obesity is closely associated with metabolic imbalance and kidney injury. Alginate oligosaccharides (AOS) are considered promising dietary bioactive compounds; however, whether they protect against obesity-associated renal damage has not been fully clarified. In this study, we investigated whether AOS ameliorates renal injury in HFD-fed mice and further used transplantation of small intestinal contents to explore the possible involvement of gut-derived factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>After AOS treatment, metabolic parameters, renal function, kidney histopathology, and related pathological alterations were evaluated. For the transplantation experiment, small intestinal contents collected from control or AOS-treated donor mice were administered to HFD-fed recipient mice, after which renal and metabolic phenotypes were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AOS improved HFD-induced metabolic disorders and alleviated renal injury. Mice treated with AOS showed lower serum blood urea nitrogen and creatinine levels, reduced renal lipid accumulation, and attenuated inflammatory and oxidative stress-related changes. Notably, recipient mice receiving small intestinal contents from AOS-treated donors also exhibited partial improvement in these abnormalities, whereas contents from control donors showed weaker or less consistent effects. These findings suggest that AOS-associated alterations in small intestinal contents may contribute to the observed renoprotective effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AOS attenuated obesity-associated renal injury in HFD-fed mice, and this effect was at least partially transferable through transplantation of small intestinal contents. This study provides supportive evidence that gut-derived factors are involved, at least in part, in the renoprotective effects associated with AOS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1915255","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T04:23:26Z","timestamp":1787631806000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Alginate oligosaccharides attenuate obesity-associated kidney injury through modulation of the intestinal environment with renoprotection transferable by small intestinal contents"],"prefix":"10.3389","volume":"13","author":[{"given":"Zhijie","family":"Song","sequence":"first","affiliation":[{"name":"Shandong Provincial Key Laboratory of Brain Science, Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences","place":["Jinan, China"]},{"name":"School of Clinical and Basic Medicine, Institute of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Brain Science, Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences","place":["Jinan, China"]},{"name":"School of Clinical and Basic Medicine, Institute of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Cao","sequence":"additional","affiliation":[{"name":"Shandong Provincial Key Laboratory of Brain Science, Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences","place":["Jinan, China"]},{"name":"School of Clinical and Basic Medicine, Institute of Basic Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Yang","sequence":"additional","affiliation":[{"name":"The School of Pharmacy, Shandong First Medical University & Shandong Academy of Medical Sciences","place":["Jinan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Yan","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Qingdao Agricultural University","place":["Qingdao, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongxin","family":"Lu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences","place":["Beijing, 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