{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:02:01Z","timestamp":1784869321676,"version":"3.55.0"},"reference-count":50,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The triglyceride high-density cholesterol-glucose body index (TyHGB) integrates atherogenic dyslipidemia, glucose metabolism, and generalized obesity, aligning closely with the pathophysiology of metabolic dysfunction-associated steatotic liver disease (MASLD). However, whether its association with MASLD follows a non-linear pattern and to what extent waist circumference (WC)-a surrogate for visceral adiposity-mediates this relationship remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study included 13,682 non-diabetic Japanese adults from a community-based cohort. Multivariable logistic regression, generalized additive models, and two-piecewise linear regression were used to evaluate the independent and non-linear association between TyHGB and prevalent MASLD. Mediation analysis with 1,000 bootstrap resamples quantified the mediating effect of WC and its heterogeneity across metabolic subgroups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The overall prevalence of MASLD was 15.25%. Each 1-unit increase in TyHGB was associated with a 1.35-fold higher odds of MASLD (OR = 1.35, 95% CI: 1.31\u20131.40,\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). A non-linear inflection point was identified at TyHGB = 9.70; below this threshold, the association was markedly stronger (OR=2.02, 95% CI: 1.88\u20132.17), whereas above it the risk increment plateaued (OR = 1.04,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.090). WC partially mediated 46.4% of the TyHGB\u2013MASLD association, with a substantially larger mediated proportion in non-obese individuals (42.67%) than in obese participants (7.83%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In non-diabetic Japanese adults, TyHGB is independently and non-linearly associated with MASLD, with WC partially mediating this relationship. The marked attenuation of WC mediation among obese individuals suggests a relative shift towards non-WC-mediated pathways under high metabolic burden. TyHGB may serve as a practical composite surrogate marker for MASLD risk stratification in community settings, particularly for non-obese individuals in whom WC captures a larger share of the risk pathway and who are frequently missed by BMI-based assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1915937","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:22:49Z","timestamp":1784866969000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Waist circumference partially mediates the non-linear association between TyHGB and MASLD in non-diabetic Japanese adults"],"prefix":"10.3389","volume":"13","author":[{"given":"Yanyan","family":"Xuan","sequence":"first","affiliation":[{"name":"Department of Hospital Infection, The First Affiliated Hospital of Ningbo University, Ningbo","place":["Zhejiang, China"]},{"name":"Department of Hepatology, The First 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