{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:05:10Z","timestamp":1790057110027,"version":"4.0.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Blueberry pomace is the by\u2013product of blueberry (\n                      <jats:italic>Vaccinium spp<\/jats:italic>\n                      .) fruits. This study aimed to prepare blueberry pomace polysaccharide (BBPP) and explore its myocardial injury protection potential.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>An acidic polysaccharide (BBPP80\u20131a) was isolated and purified from active BBPP80-1 fraction. Its structure was characterized based on some approaches. Its myocardial injury protection potential was performed in hypoxia\/reoxygenation (H\/R)-induced H9c2 cells injury model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The molecular weight of BBPP80\u20131a was 164.91 kDa. The ratio of galacturonic acid (GalA) was 50.92% in methylation results. Further, nuclear magnetic resonance data suggested repetitive \u2192 4)-\u03b1-D-Gal\n                      <jats:italic>p<\/jats:italic>\n                      A-(1 \u2192 and \u2192 4)-\u03b1-D-Gal\n                      <jats:italic>p<\/jats:italic>\n                      A-6-OMe-(1 \u2192 residues occupied the homogalacturonan region of backbone. It had a highly porous, reticular, and heterogeneous microstructures. Moreover, BBPP80\u20131a can obviously protect H9c2 cells from H\/R injury\n                      <jats:italic>via<\/jats:italic>\n                      phosphoinositide 3-kinase \/ protein kinase B \/ mammalian target of rapamycin (PI3K\/AKT\/mTOR) and\n                      <jats:italic>c<\/jats:italic>\n                      -Jun\n                      <jats:italic>N<\/jats:italic>\n                      -terminal kinase \/ mitogen-activated protein kinase (JNK\/MAPK) pathways.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>BBPP80\u20131a is a pectic polysaccharide. It exhibited the potential on cardioprotective effect through the activation of PI3K\/AKT\/mTOR survival pathway and the regulation of JNK\/MAPK pathways.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1920321","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:39:29Z","timestamp":1790055569000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural characterization and in vitro myocardial injury protection potential of one acidic polysaccharide from blueberry (Vaccinium spp.) pomace"],"prefix":"10.3389","volume":"13","author":[{"given":"Beibei","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Henan Province Engineering Research Center of Application & Translation of Precision Clinical Pharmacy, The First Affiliated Hospital of Zhengzhou University","place":["Zhengzhou, 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