{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:19:26Z","timestamp":1788365966827,"version":"build-2803163510"},"reference-count":48,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Polyphenol-rich sugarcane extracts (PRSEs) are food-derived sources of naturally occurring bioactive polyphenols with increasing relevance to metabolic regulation, gut microbiome function, and overall well-being.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This fully remote trial investigated the effects of PRSE supplementation on cardiometabolic biomarkers and gut microbiota.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Healthy adults aged 18\u201355\u202fyears (\n                      <jats:italic>n<\/jats:italic>\n                      \u202f=\u202f47, female\u202f=\u202f36 and male\u202f=\u202f11) residing in Australia were recruited to a remote quadruple-blinded, randomised, placebo-controlled cross-over trial, with each intervention arm lasting 90\u202fdays. Participants received PRSE oral capsules at 500\u202fmg\/day (two 250\u202fmg doses) or maltodextrin placebo capsules. Blood and faecal samples were collected for subsequent blood biomarkers and microbiome analyses, respectively. Self-reported qualitative surveys were conducted to assess overall wellbeing over the 6-month period.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant treatment \u00d7 time effects were observed for circulating\n                      <jats:italic>trans<\/jats:italic>\n                      -fatty acids (%), triglycerides and VLDL cholesterol, as well as several microbial metabolic pathways, including glycerol degradation III, pyruvate dehydrogenase, and\n                      <jats:italic>p<\/jats:italic>\n                      -cresol degradation. No significant effects were detected for body weight, inflammatory, or glycaemic markers following correction for multiple comparisons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      PRSE supplementation was associated with a lower circulating proportion of\n                      <jats:italic>trans<\/jats:italic>\n                      -fatty acids, and lower triglyceride and VLDL cholesterol concentrations compared with placebo. PRSE supplementation also modulated selected microbial functional pathways without affecting overall microbiome diversity or community composition. These findings support the biological activity of PRSE and suggest potential interactions between host metabolic and microbiome-related mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?id=386733&amp;amp;isReview=true<\/jats:ext-link>\n                      , identifier, ANZCTR; ACTRN12624000055505.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1923420","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T15:41:15Z","timestamp":1788363675000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Polyphenol-rich sugarcane extract reduces circulating trans fatty acids, VLDL cholesterol, and triglycerides in healthy adults"],"prefix":"10.3389","volume":"13","author":[{"given":"Simone","family":"Lewin","sequence":"first","affiliation":[{"name":"ARC Training Centre for Hyphenated Analytical Separation Technologies (HyTECH)","place":["Hobart, TAS, Australia"]},{"name":"Deakin Centre for Advanced Food Sciences, School of Exercise and Nutrition Sciences, Deakin University","place":["Burwood, VIC, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Hartley","sequence":"additional","affiliation":[{"name":"Deakin Centre for Advanced Food Sciences, School of Exercise and Nutrition Sciences, Deakin University","place":["Burwood, VIC, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalia Marina","family":"Llalla Vidal","sequence":"additional","affiliation":[{"name":"Bioactives Division, The Product Makers Australia Pty Ltd.","place":["Keysborough, VIC, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayson J. A.","family":"Rose","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Anatomy, Physiology and Pharmacology, La Trobe University","place":["Bundoora, VIC, Australia"]},{"name":"La Trobe Institute for Molecular Sciences (LIMS), La Trobe University","place":["Bundoora, VIC, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Costanzo","sequence":"additional","affiliation":[{"name":"Deakin Centre for Advanced Food Sciences, School of Exercise and Nutrition Sciences, Deakin University","place":["Burwood, VIC, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snehal R.","family":"Jadhav","sequence":"additional","affiliation":[{"name":"ARC Training Centre for Hyphenated Analytical Separation Technologies (HyTECH)","place":["Hobart, TAS, Australia"]},{"name":"Deakin Centre for Advanced Food Sciences, School of Exercise and Nutrition Sciences, Deakin University","place":["Burwood, VIC, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacoba","family":"Bromfield","sequence":"additional","affiliation":[{"name":"Cmbio, Fruebjergvej","place":["Copenhagen, Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell S. 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