{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T11:10:55Z","timestamp":1788952255501,"version":"build-2803163510"},"reference-count":67,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Quercetin is a representative flavonol at the interface of natural-product pharmacology, nutrition, and immune regulation, with reported anti-inflammatory, antioxidant, antiviral, antiallergic, antitumor, and metabolic activities. This systematic mapping review aimed to characterize the publication trajectory, knowledge structure, latent themes, and emerging frontiers of quercetin-immunity research from 2006 to 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>English-language original articles and reviews published from January 1, 2006 to December 31, 2025 were retrieved from the Web of Science Core Collection, Scopus, and PubMed. Following harmonized eligibility reassessment, field standardization, and cross-database deduplication, bibliometric analysis, science mapping, keyword co-occurrence, temporal and burst analyses, thematic maturity assessment, citation and co-citation analyses, and latent Dirichlet allocation (LDA) topic modeling were integrated to examine the explicit and latent knowledge structures. Mapping-level risk of bias was qualitatively assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The searches yielded 15,938 raw records, of which 10,619 unique publications were included, comprising 7,754 original articles and 2,865 reviews. Of these, 6,440 publications appeared during 2021\u20132025, accounting for 60.65% of the dataset and demonstrating rapid growth. The field spanned natural products, pharmacology, molecular biology, nutrition, and immunology, with China, India, and the United States as the leading contributors. Stable mechanistic terms included oxidative stress, inflammation, signal transduction, apoptosis, NF-\u03baB, TNF, IL-6, and IL-1\u03b2, indicating a knowledge core centered on inflammatory cytokine networks, redox homeostasis, transcriptional regulation, and cell-fate control. LDA resolved 12 topics spanning inflammatory signaling, systems pharmacology, senescence, oxidative organ injury, tumor immunity, neuroinflammation and ferroptosis, infection and intestinal inflammation, allergy and mast-cell activation, delivery systems, and bioavailability. Recent frontiers included molecular docking, network pharmacology, protein\u2013protein interaction, Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology analyses, ferroptosis, macrophage polarization, and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling, indicating a shift toward multi-target, systems-level mechanistic investigation. The mapping-level assessment indicated low-to-moderate residual risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Quercetin-immunity research has evolved from broad anti-inflammatory studies into an interdisciplinary field focused on inflammatory signaling, oxidative stress, immune-cell function, disease-specific immunopathology, and systems pharmacology. Future studies should prioritize physiologically attainable exposures, active metabolites, immune-cell specificity, disease-stage effects, multi-omics validation, and clinically relevant dosing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1932000","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:18:17Z","timestamp":1788949097000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Knowledge structure, latent topics, and emerging trends in quercetin-immunity research from 2006 to 2025: a bibliometric and LDA topic-modeling analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Congcong","family":"Qin","sequence":"first","affiliation":[{"name":"Institute of Chinese Medical Literature and Culture, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"The First Clinical Medical College, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"Emergency and Critical Care Medicine Center, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqing","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medical Literature and Culture, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengyun","family":"Tian","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"The First Clinical Medical College, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"Emergency and Critical Care Medicine Center, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailiang","family":"Fan","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"The First Clinical Medical College, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"Emergency and Critical Care Medicine Center, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyuan","family":"Du","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"The First Clinical Medical College, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"Emergency and Critical Care Medicine Center, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejin","family":"Ba","sequence":"additional","affiliation":[{"name":"Inner Mongolia International Mongolian Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuanglin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Inner Mongolia International Mongolian Hospital","place":["Hohhot, Inner Mongolia, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochen","family":"Li","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"The First Clinical Medical College, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"Emergency and Critical Care Medicine Center, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Kong","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"The First Clinical Medical College, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"Emergency and Critical Care Medicine Center, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"856","DOI":"10.17179\/excli2018-1538","article-title":"Quercetin and its role in biological functions: an updated review","volume":"17","author":"Kim","year":"2018","journal-title":"EXCLI J"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"964149","DOI":"10.1155\/2013\/964149","article-title":"Historical aspects of propolis research in modern times","volume":"2013","author":"Kuropatnicki","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/138027a0","article-title":"Vitamin P: flavonols as vitamins","volume":"138","author":"Ruszny\u00e1k","year":"1936","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/s0031-9422(00)00235-1","article-title":"Advances in flavonoid research since 1992","volume":"55","author":"Harborne","year":"2000","journal-title":"Phytochemistry"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1093\/ajcn\/79.5.727","article-title":"Polyphenols: food sources and bioavailability","volume":"79","author":"Manach","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.3390\/molecules24061123","article-title":"Antioxidant activities of quercetin and its complexes for medicinal application","volume":"24","author":"Xu","year":"2019","journal-title":"Molecules"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.ejphar.2008.03.008","article-title":"Health effects of quercetin: from antioxidant to nutraceutical","volume":"585","author":"Boots","year":"2008","journal-title":"Eur J Pharmacol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3390\/nu8030167","article-title":"Quercetin, inflammation and immunity","volume":"8","author":"Li","year":"2016","journal-title":"Nutrients"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2010.02.029","article-title":"Nonresolving inflammation","volume":"140","author":"Nathan","year":"2010","journal-title":"Cell"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1023\/a:1021624520740","article-title":"Quercetin suppresses proinflammatory cytokines production through MAP kinases and NF-kappaB pathway in lipopolysaccharide-stimulated macrophage","volume":"243","author":"Cho","year":"2003","journal-title":"Mol Cell Biochem"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"e0141509","DOI":"10.1371\/journal.pone.0141509","article-title":"Quercetin attenuates inflammatory responses in BV-2 microglial cells: role of MAPKs on the Nrf2 pathway and induction of Heme Oxygenase-1","volume":"10","author":"Sun","year":"2015","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"41539","DOI":"10.1038\/srep41539","article-title":"Quercetin inhibits Inflammasome activation by interfering with ASC oligomerization and prevents Interleukin-1 mediated mouse Vasculitis","volume":"7","author":"Domiciano","year":"2017","journal-title":"Sci Rep"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.intimp.2017.11.013","article-title":"Quercetin attenuates collagen-induced arthritis by restoration of Th17\/Treg balance and activation of Heme oxygenase 1-mediated anti-inflammatory effect","volume":"54","author":"Yang","year":"2018","journal-title":"Int Immunopharmacol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"e33805","DOI":"10.1371\/journal.pone.0033805","article-title":"Quercetin is more effective than cromolyn in blocking human mast cell cytokine release and inhibits contact dermatitis and photosensitivity in humans","volume":"7","author":"Weng","year":"2012","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1016\/j.ebiom.2018.12.052","article-title":"Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human, open-label, pilot study","volume":"40","author":"Justice","year":"2019","journal-title":"EBioMedicine"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.ebiom.2019.08.069","article-title":"Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of Dasatinib plus quercetin in individuals with diabetic kidney disease","volume":"47","author":"Hickson","year":"2019","journal-title":"EBioMedicine"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.29219\/fnr.v66.8948","article-title":"Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4\/NF-\u03baB\/NLRP3 signaling pathway in vivo and in vitro","volume":"66","author":"Zhang","year":"2022","journal-title":"Food Nutr Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e2300051","DOI":"10.1002\/mnfr.202300051","article-title":"pH sensitive quercetin nanoparticles ameliorate DSS-induced colitis in mice by Colon-specific delivery","volume":"68","author":"Wang","year":"2024","journal-title":"Mol Nutr Food Res"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"156633","DOI":"10.1016\/j.phymed.2025.156633","article-title":"Quercetin protected the gut barrier in ulcerative colitis by activating aryl hydrocarbon receptor","volume":"140","author":"Wei","year":"2025","journal-title":"Phytomedicine"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"102010","DOI":"10.1016\/j.redox.2021.102010","article-title":"Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy","volume":"44","author":"Han","year":"2021","journal-title":"Redox Biol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"176264","DOI":"10.1016\/j.ejphar.2023.176264","article-title":"Quercetin attenuates cerebral ischemic injury by inhibiting ferroptosis via Nrf2\/HO-1 signaling pathway","volume":"963","author":"Peng","year":"2024","journal-title":"Eur J Pharmacol"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"230S","DOI":"10.1093\/ajcn\/81.1.230S","article-title":"Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies","volume":"81","author":"Manach","year":"2005","journal-title":"Am J Clin Nutr"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"140262","DOI":"10.1016\/j.foodchem.2024.140262","article-title":"The bioavailability, absorption, metabolism, and regulation of glucolipid metabolism disorders by quercetin and its important glycosides: a review","volume":"458","author":"Zhu","year":"2024","journal-title":"Food Chem"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/1541-4337.12342","article-title":"Bioavailability of quercetin in humans with a focus on Interindividual variation","volume":"17","author":"Almeida","year":"2018","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.jbusres.2021.04.070","article-title":"How to conduct a bibliometric analysis: an overview and guidelines","volume":"133","author":"Donthu","year":"2021","journal-title":"J Bus Res"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: an R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J Informetr"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1145\/2133806.2133826","article-title":"Probabilistic topic models","volume":"55","author":"Blei","year":"2012","journal-title":"Commun ACM"},{"key":"ref29","first-page":"399","author":"R\u00f6der","year":"2015"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/19312458.2018.1430754","article-title":"Applying LDA topic modeling in communication research: toward a valid and reliable methodology","volume":"12","author":"Maier","year":"2018","journal-title":"Commun Methods Meas"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"160","author":"Valko","year":"2006","journal-title":"Chem Biol Interact"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J Cheminform"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J Comput Chem"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1016\/j.imbio.2013.04.019","article-title":"Quercetin disrupts tyrosine-phosphorylated phosphatidylinositol 3-kinase and myeloid differentiation factor-88 association, and inhibits MAPK\/AP-1 and IKK\/NF-\u03baB-induced inflammatory mediators production in RAW 264.7 cells","volume":"218","author":"Endale","year":"2013","journal-title":"Immunobiology"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1146\/annurev.immunol.18.1.621","article-title":"Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity","volume":"18","author":"Karin","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.abb.2019.06.007","article-title":"Quercetin suppressed NADPH oxidase-derived oxidative stress via heme oxygenase-1 induction in macrophages","volume":"671","author":"Luo","year":"2019","journal-title":"Arch Biochem Biophys"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"6949","DOI":"10.3390\/molecules26226949","article-title":"Quercetin prevents LPS-induced oxidative stress and inflammation by modulating NOX2\/ROS\/NF-kB in lung epithelial cells","volume":"26","author":"Sul","year":"2021","journal-title":"Molecules"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","article-title":"Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway","volume":"47","author":"Kensler","year":"2007","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3390\/nu14010067","article-title":"Regulatory effects of quercetin on M1\/M2 macrophage polarization and oxidative\/antioxidative balance","volume":"14","author":"Tsai","year":"2021","journal-title":"Nutrients"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu Rev Pathol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"118","DOI":"10.3892\/ijmm.2023.5321","article-title":"Quercetin alleviates lipopolysaccharide-induced acute lung injury by inhibiting ferroptosis via the Sirt1\/Nrf2\/Gpx4 pathway","volume":"52","author":"Deng","year":"2023","journal-title":"Int J Mol Med"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"e16703","DOI":"10.7717\/peerj.16703","article-title":"Quercetin alleviates PM2.5-induced chronic lung injury in mice by targeting ferroptosis","volume":"12","author":"Ding","year":"2024","journal-title":"PeerJ"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1038\/ijo.2010.272","article-title":"Quercetin attenuates inflammation in human macrophages and adipocytes exposed to macrophage-conditioned media","volume":"35","author":"Overman","year":"2011","journal-title":"Int J Obes"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3390\/nu9070650","article-title":"Quercetin protects obesity-induced hypothalamic inflammation by reducing microglia-mediated inflammatory responses via HO-1 induction","volume":"9","author":"Yang","year":"2017","journal-title":"Nutrients"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"808","DOI":"10.1016\/j.intimp.2013.09.009","article-title":"Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-\u03baB pathway and activating the Nrf2-dependent HO-1 pathway","volume":"17","author":"Kang","year":"2013","journal-title":"Int Immunopharmacol"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"111080","DOI":"10.1016\/j.brainresbull.2024.111080","article-title":"Quercetin alleviates microglial-induced inflammation after traumatic brain injury via the PGC-1\u03b1\/Nrf2 pathway dependent on HDAC3 inhibition","volume":"217","author":"Zhai","year":"2024","journal-title":"Brain Res Bull"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"951716","DOI":"10.3389\/fmicb.2022.951716","article-title":"Quercetin, a flavonoid, combats rotavirus infection by deactivating rotavirus-induced pro-survival NF-\u03baB pathway","volume":"13","author":"Banerjee","year":"2022","journal-title":"Front Microbiol"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.3389\/fimmu.2020.01451","article-title":"Quercetin and vitamin C: an experimental, synergistic therapy for the prevention and treatment of SARS-CoV-2 related disease (COVID-19)","volume":"11","author":"Colunga Biancatelli","year":"2020","journal-title":"Front Immunol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1483459","DOI":"10.3389\/fimmu.2024.1483459","article-title":"From nature to clinic: quercetin's role in breast cancer immunomodulation","volume":"15","author":"Fang","year":"2024","journal-title":"Front Immunol"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.actbio.2022.10.008","article-title":"Quercetin-ferrum nanoparticles enhance photothermal therapy by modulating the tumor immunosuppressive microenvironment","volume":"154","author":"Li","year":"2022","journal-title":"Acta Biomater"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1186\/s12935-021-02345-5","article-title":"To explore immune synergistic function of quercetin in inhibiting breast cancer cells","volume":"21","author":"Qiu","year":"2021","journal-title":"Cancer Cell Int"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.3390\/foods9081121","article-title":"The human microbial metabolism of quercetin in different formulations: an in vitro evaluation","volume":"9","author":"Di Pede","year":"2020","journal-title":"Foods"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s13318-018-0517-3","article-title":"Improved Oral absorption of quercetin from quercetin Phytosome\u00ae, a new delivery system based on food grade lecithin","volume":"44","author":"Riva","year":"2019","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.tifs.2016.07.004","article-title":"The biological activities, chemical stability, metabolism and delivery systems of quercetin: a review","volume":"56","author":"Wang","year":"2016","journal-title":"Trends Food Sci Technol"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1089\/ars.2015.6615","article-title":"Nuclear factor E2-related Factor-2 negatively regulates NLRP3 Inflammasome activity by inhibiting reactive oxygen species-induced NLRP3 priming","volume":"26","author":"Liu","year":"2017","journal-title":"Antioxid Redox Signal"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1002\/eji.201646665","article-title":"Opposing effects of Nrf2 and Nrf2-activating compounds on the NLRP3 inflammasome independent of Nrf2-mediated gene expression","volume":"47","author":"Garstkiewicz","year":"2017","journal-title":"Eur J Immunol"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/exd.14205","article-title":"SASP-induced macrophage dysfunction may contribute to accelerated senescent fibroblast accumulation in the dermis","volume":"30","author":"Ogata","year":"2021","journal-title":"Exp Dermatol"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The gene ontology consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat Genet"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1932000\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:18:18Z","timestamp":1788949098000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1932000\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":67,"alternative-id":["10.3389\/fnut.2026.1932000"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1932000","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"article-number":"1932000"}}