{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T06:02:14Z","timestamp":1789970534861,"version":"4.0.1"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Shiliang tea, derived from the leaves of\n                      <jats:italic>Chimonanthus salicifolius<\/jats:italic>\n                      , has traditionally been used to manage gastrointestinal disorders. This study aimed to isolate and characterize a polysaccharide from\n                      <jats:italic>Chimonanthus salicifolius<\/jats:italic>\n                      (CSP) and evaluate its therapeutic effects in a murine model of diabetes mellitus\u2011associated colitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The structural features of CSP were determined using gel permeation chromatography, gas chromatography\u2013mass spectrometry, and nuclear magnetic resonance spectroscopy. Following oral administration of CSP, colonic tissues from diabetic mice were collected for histological examination. Concentrations of short\u2011chain fatty acids (SCFAs) in colonic contents were measured by gas chromatography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A polysaccharide (CSP) with an approximate molecular mass of 574.7 kDa was isolated from Chimonanthus salicifolius. Methylation analysis revealed that CSP comprises ten distinct sugar residues, while NMR spectra showed the presence of terminal \u03b1-arabinofuranosyl (T-\u03b1-Araf), 1,5- and 1,3,5-linked \u03b1-Araf, terminal \u03b2-galactopyranosyl (T-\u03b2-Galp), 1,3,6-, 1,4,6-, 1,4-, and 1,3-substituted \u03b2-Galp, as well as 1,4- and 1,3-linked \u03b1-glucopyranosyl (\u03b1-Glcp) residues in CSP. CSP administration markedly attenuated hyperglycemia and impeded the progression of ulcerative colitis in diabetic mice. CSP significantly suppressed pro inflammatory cytokine production, predominantly via blockade of NF\u2011\u03baB signaling cascade. CSP reinforced intestinal epithelial barrier function through upregulation of tight junction associated proteins, including claudin 1, occludin, and zonula occludens 1, and concurrently elevated the concentrations of SCFAs within the colonic lumen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results indicate that CSP is a bioactive polysaccharide with demonstrable biological activity in animal models, warranting further investigation as a potential therapeutic agent for diabetic colitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1934103","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:36:20Z","timestamp":1789968980000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Structural characterization and effect on diabetes mellitus with ulcerative colitis of polysaccharide from Chimonanthus salicifolius"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiaoqin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Lishui Hospital of Traditional Chinese Medicine","place":["Lishui, China"]},{"name":"Zhejiang Provincial Key Laboratory of She Medicine Inheritance, Innovation, Development and Application of Traditional Chinese Medicine","place":["Lishui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Lishui Hospital of Traditional Chinese Medicine","place":["Lishui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingfeng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Lishui Hospital of Traditional Chinese Medicine","place":["Lishui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Lishui Hospital of Traditional Chinese Medicine","place":["Lishui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songquan","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Medicine, Lishui University","place":["Lishui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Medicine, Lishui University","place":["Lishui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Medicine, Lishui University","place":["Lishui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houxing","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Lishui Hospital of Traditional Chinese Medicine","place":["Lishui, China"]},{"name":"Lishui She Medicine Inheritance, Innovation, Development and Application Key Laboratory of Traditional Chinese Medicine","place":["Lishui, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nani","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine","place":["Hangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"132698","DOI":"10.1016\/j.foodchem.2022.132698","article-title":"Proteomics and metabolomics reveal the mechanism underlying differential antioxidant activity among the organs of two base plants of Shiliang tea (Chimonanthus salicifolius and Chimonanthus zhejiangensis)","volume":"385","author":"Yang","year":"2022","journal-title":"Food Chem"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1093\/chromsci\/bmw053","article-title":"A fast and reliable UPLC-PAD fingerprint analysis of Chimonanthus salicifolius combined with chemometrics methods","volume":"54","author":"Liang","year":"2016","journal-title":"J Chromatogr Sci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"1168049","DOI":"10.3389\/fnut.2023.1168049","article-title":"Antioxidant, antihyperglycemic, and antihyperlipidemic properties of Chimonanthus salicifolius S. 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