{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:01:16Z","timestamp":1790182876539,"version":"4.1.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The triglyceride-glucose (TyG) index is a surrogate marker of insulin resistance and has been associated with atrial fibrillation (AF) risk, but it does not capture adiposity. The triglyceride-high-density lipoprotein-glucose-body (TyHGB) index, which integrates lipid profile, glucose metabolism, and body mass index, may provide a more comprehensive metabolic assessment. However, evidence regarding its association with AF remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case-control study included 1,137 participants (314 non-AF controls, 414 paroxysmal AF, and 409 persistent AF). Multivariable logistic regression was performed using three hierarchical models. Restricted cubic splines were used to examine non-linear relationships. Receiver operating characteristic curves were generated to compare the predictive performance of TyHGB, TyG, and their combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both TyHGB and TyG were independently associated with AF risk across all models (all\n                      <jats:italic>P<\/jats:italic>\n                      &amp;lt; 0.001). In the fully adjusted model, each one-unit increase in TyHGB was associated with a 61% increase in the odds of AF (OR 1.61, 95% CI 1.41\u20131.85). Significant non-linear dose-response relationships were observed for both indices (\n                      <jats:italic>P<\/jats:italic>\n                      for non-linear &amp;lt; 0.001). The predictive performance of TyHGB was comparable to TyG (AUC 0.716 vs. 0.717,\n                      <jats:italic>P<\/jats:italic>\n                      = 0.902). The combined model achieved the highest AUC (0.723) and significantly outperformed TyG alone (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.002), though it was not superior to TyHGB alone (\n                      <jats:italic>P<\/jats:italic>\n                      = 0.366).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TyHGB is a novel, simple, and low-cost metabolic index independently associated with AF risk, with predictive performance comparable to TyG. It may serve as a convenient complementary marker for metabolic risk assessment in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1940518","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:08:49Z","timestamp":1790179729000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between the triglyceride-high-density lipoprotein-glucose-body index and atrial fibrillation: a retrospective case-control study"],"prefix":"10.3389","volume":"13","author":[{"given":"Yunling","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Disease, The First Hospital of Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuebo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Disease, The First Hospital of Jilin 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