{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:06:53Z","timestamp":1790057213790,"version":"4.0.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:00:00Z","timestamp":1790035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although numerous meta-analyses have investigated the effects of soy and isoflavones on lipid profiles in postmenopausal women, a comprehensive evaluation of this evidence remains lacking. This umbrella review synthesized existing meta-analyses of randomized controlled trials to assess the certainty of the evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, Web of Science, Embase, and the Cochrane Database for studies published through April 22, 2026. Methodological quality was evaluated using AMSTAR-2, and evidence certainty was assessed using the GRADE approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seven meta-analyses comprising 21 associations were included. According to AMSTAR-2, two meta-analyses (29%) demonstrated moderate or high quality. Eighteen associations were supported by evidence of moderate or high certainty according to GRADE. Soy protein containing isoflavones and soy isoflavone extracts significantly reduced total cholesterol (MD = \u22120.12 mmol\/L, 95% CI: \u22120.21 to \u22120.03). Soy isoflavones reduced low-density lipoprotein cholesterol (SMD = \u22120.11, 95% CI: \u22120.21 to \u22120.01). Furthermore, unfermented soy products significantly increased high-density lipoprotein cholesterol (MD = 0.06 mmol\/L, 95% CI: 0.02 to 0.10).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Specific soy-based interventions, rather than general soy consumption, were associated with beneficial changes in lipid profiles among postmenopausal women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>CRD420251243075.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1949200","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T05:40:46Z","timestamp":1790055646000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of soy and isoflavone interventions on plasma lipid profiles in postmenopausal women: an umbrella review"],"prefix":"10.3389","volume":"13","author":[{"given":"Jia-He","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Shengjing Hospital of China Medical University","place":["Shenyang, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Jian","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Quanzhou First Hospital Affiliated to Fujian Medical University","place":["Quanzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Li","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Jie","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Yili Kazakh Autonomous Prefecture Tacheng District People's Hospital","place":["Tacheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aykede","family":"Abdurazzak","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, School of Pharmacy, China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lian-Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department 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Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling-Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ning","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Reproductive Medicine, Shengjing Hospital of China Medical University","place":["Shenyang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"155282","DOI":"10.1016\/j.cyto.2020.155282","article-title":"The effects of soy supplementation on inflammatory biomarkers: a systematic review and meta-analysis of randomized controlled 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