{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:01:01Z","timestamp":1790830861741,"version":"4.1.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"\n Objectives<\/jats:title>\n \n Curcuma longa<\/jats:italic>\n , commonly known as turmeric, is a dietary spice with potential biological effects. This study evaluated the association between intake of\n C. longa<\/jats:italic>\n extracts (CLE) and cognitive function in individuals with mild cognitive impairment (MCI) due to Alzheimer\u2019s disease (AD).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This was a 4-month, single-arm, open-label, observational study of participants with MCI due to AD who were awaiting anti-amyloid therapy. Participants (\n n<\/jats:italic>\n \u202f=\u202f13) consumed the test food containing CLE, which includes the compounds bisacurone and turmeronols. Cognitive function was assessed at baseline and after 4\u202fmonths using various cognitive assessments.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n After excluding participants with insufficient intake of CLE capsules or invalid data, 10 participants were included in the analysis set, consisting of 2 men and 8 women, with a mean \u00b1 standard deviation age of 74.8\u202f\u00b1\u202f6.1\u202fyears. CLE intake was associated with significantly higher memory scores (Composite B) and significantly lower estimated brain age at 4\u202fmonths compared with baseline, as measured by a digital cognitive assessment tool (Nou-Know). In the Japanese version of the Montreal Cognitive Assessment, total scores did not differ significantly after CLE intake, but subscale scores for the attention domain and digit span test increased significantly from baseline.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n This observational study provides preliminary evidence of a potential association between CLE intake and changes in frontal lobe-mediated functions, particularly working memory, in individuals with MCI due to AD, and further investigation is warranted.<\/jats:p>\n <\/jats:sec>\n \n Clinical trial registration<\/jats:title>\n \n https:\/\/center6.umin.ac.jp\/cgi-open-bin\/icdr_e\/ctr_view.cgi?recptno=R000058932<\/jats:ext-link>\n , identifier UMIN-CTR, UMIN000052043.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fnut.2026.1951923","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:48:44Z","timestamp":1790830124000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Influence of Curcuma longa extract on cognitive function in mild cognitive impairment due to Alzheimer\u2019s disease: a single-arm, open-label, observational study"],"prefix":"10.3389","volume":"13","author":[{"given":"Yuta","family":"Manabe","sequence":"first","affiliation":[{"name":"Division of Dementia and Geriatric Medicine, Department of Advanced Clinical Medicine, Kanagawa Dental University School of Dentistry","place":["Yokosuka, Japan"]},{"name":"Dementia Diagnosis Center, Department of Internal Medicine, Yokohama Shintoshi Neurosurgical Hospital","place":["Yokohama-shi, Kanagawa, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"2576","DOI":"10.1039\/D1CC07000B","article-title":"Detoxification of amyloid \u03b2 fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model","volume":"58","author":"Utomo","year":"2022","journal-title":"Chem Commun (Camb)"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"8370","DOI":"10.1523\/JNEUROSCI.21-21-08370.2001","article-title":"The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse","volume":"21","author":"Lim","year":"2001","journal-title":"J Neurosci"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3233\/JAD-170512","article-title":"Protective effects of Indian spice curcumin against amyloid-\u03b2 in Alzheimer\u2019s disease","volume":"61","author":"Reddy","year":"2018","journal-title":"J Alzheimer's Dis"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"108729","DOI":"10.1016\/j.cbi.2019.108729","article-title":"Therapeutic effects of turmeric in several diseases: an overview","volume":"310","author":"Hay","year":"2019","journal-title":"Chem Biol Interact"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1002\/mnfr.201200838","article-title":"Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: identification of novel components of turmeric","volume":"57","author":"Aggarwal","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"172","DOI":"10.12938\/bmfh.2022-071","article-title":"Turmeronols (a and B) from Curcuma longa have anti-inflammatory effects in lipopolysaccharide-stimulated BV-2 microglial cells by reducing NF-\u03baB signaling","volume":"42","author":"Saji","year":"2023","journal-title":"Biosci Microbiota Food Health"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1324196","DOI":"10.3389\/fnut.2024.1324196","article-title":"Curcuma longa extract reduces serum inflammatory markers and postprandial hyperglycemia in healthy but borderline participants with overweight and glycemia in the normal\/prediabetes range: a randomized, double-blind, and placebo-controlled trial","volume":"11","author":"Uchio","year":"2024","journal-title":"Front Nutr"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1093\/jpp\/rgaf034","article-title":"Curcuma longa L. extract and residue prevent Alzheimer's disease in mice by regulating microglia and TLR4\/NF-\u03baB signaling pathway","volume":"77","author":"Xu","year":"2025","journal-title":"J Pharm Pharmacol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1093\/aje\/kwj267","article-title":"Curry consumption and cognitive function in the elderly","volume":"164","author":"Ng","year":"2006","journal-title":"Am J Epidemiol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"100248","DOI":"10.1016\/j.tjpad.2025.100248","article-title":"Targeting cognitive aging with curcumin supplementation: a systematic review and meta-analysis","volume":"12","author":"Yu","year":"2025","journal-title":"J Prev Alzheimers Dis"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1866285","DOI":"10.3389\/fnut.2026.1866285","article-title":"Effects of Curcuma longa extract on cognitive function in healthy participants with subtle cognitive weaknesses within the normal range: a randomized, double-blind, placebo-controlled trial","volume":"13","author":"Saji","year":"2026","journal-title":"Front Nutr"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/j.foodchem.2015.08.034","article-title":"Development of intron length polymorphism markers in genes encoding diketide-CoA synthase and curcumin synthase for discriminating Curcuma species","volume":"194","author":"Kita","year":"2016","journal-title":"Food Chem"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1186\/s12937-021-00748-8","article-title":"Curcuma longa extract improves serum inflammatory markers and mental health in healthy participants who are overweight: a randomized, double-blind, placebo-controlled trial","volume":"20","author":"Uchio","year":"2021","journal-title":"Nutr J"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.jep.2011.08.055","article-title":"Experimental study on anti-inflammatory activity of a TCM recipe consisting of the supercritical fluid CO2 extract of Chrysanthemum indicum, patchouli oil and zedoary turmeric oil in vivo","volume":"141","author":"Su","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/j.1447-0594.2010.00585.x","article-title":"Brief screening tool for mild cognitive impairment in older Japanese: validation of the Japanese version of the Montreal cognitive assessment","volume":"10","author":"Fujiwara","year":"2010","journal-title":"Geriatr Gerontol Int"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/S0887-6177(03)00039-8","article-title":"Trail making test a and B: normative data stratified by age and education","volume":"19","author":"Tombaugh","year":"2004","journal-title":"Arch Clin Neuropsychol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3233\/JAD-200087","article-title":"Diagnostic and prognostic accuracy of the Cogstate brief battery and auditory verbal learning test in preclinical Alzheimer's disease and incident mild cognitive impairment: implications for defining subtle objective cognitive impairment","volume":"76","author":"Stricker","year":"2020","journal-title":"J Alzheimer's Dis"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"861","DOI":"10.3233\/JAD-210251","article-title":"A comparison of cross-sectional and longitudinal methods of defining objective subtle cognitive decline in preclinical Alzheimer\u2019s disease based on Cogstate one card learning accuracy performance","volume":"83","author":"Pudumjee","year":"2021","journal-title":"J Alzheimer's Dis"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1093\/arclin\/acp010","article-title":"Validity of the CogState brief battery: relationship to standardized tests and sensitivity to cognitive impairment in mild traumatic brain injury, schizophrenia, and AIDS dementia complex","volume":"24","author":"Maruff","year":"2009","journal-title":"Arch Clin Neuropsychol"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"863","DOI":"10.3389\/fpsyg.2013.00863","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs","volume":"4","author":"Lakens","year":"2013","journal-title":"Front Psychol"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"6972","DOI":"10.1002\/alz.14170","article-title":"An 18-month multimodal intervention trial for preventing dementia: J-MINT PRIME Tamba","volume":"20","author":"Oki","year":"2024","journal-title":"Alzheimers Dement"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3389\/fnagi.2019.00212","article-title":"The transfer effects of cognitive training on working memory among Chinese older adults with mild cognitive impairment: a randomized controlled trial","volume":"11","author":"Weng","year":"2019","journal-title":"Front Aging Neurosci"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/B978-0-12-804281-6.00020-3","article-title":"Aging of the frontal lobe","volume":"163","author":"Zanto","year":"2019","journal-title":"Handb Clin Neurol"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/2050-7283-1-30","article-title":"Clinical utility of the cogstate brief battery in identifying cognitive impairment in mild cognitive impairment and Alzheimer\u2019s disease","volume":"1","author":"Maruff","year":"2013","journal-title":"BMC Psychol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"e045446","DOI":"10.1002\/alz.045446","article-title":"Initial exploration of a brain age score based on validated computerized cognitive assessments in Japanese individuals","volume":"16","author":"Edgar","year":"2020","journal-title":"Alzheimers Dement"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"S91","DOI":"10.1093\/geronb\/gbae185","article-title":"Cognitive domains in the National Social Life, health, and aging project","volume":"80","author":"Zhong","year":"2025","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.3389\/fpsyg.2016.01547","article-title":"The relationship between sleep complaints, depression, and executive functions on older adults","volume":"7","author":"de Almons","year":"2016","journal-title":"Front Psychol"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1186\/1471-2202-11-118","article-title":"Practice effects in healthy adults: a longitudinal study on frequent repetitive cognitive testing","volume":"11","author":"Bartels","year":"2010","journal-title":"BMC Neurosci"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1080\/13854046.2015.1087596","article-title":"Longitudinal change in performance on the Montreal cognitive assessment in older adults","volume":"29","author":"Cooley","year":"2015","journal-title":"Clin Neuropsychol"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"105900","DOI":"10.1016\/j.neuint.2024.105900","article-title":"An overview of the relationship between inflammation and cognitive function in humans, molecular pathways and the impact of nutraceuticals","volume":"181","author":"Mekhora","year":"2024","journal-title":"Neurochem Int"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"3295","DOI":"10.1007\/s12035-018-1283-6","article-title":"Brain-derived neurotrophic factor in brain disorders: focus on Neuroinflammation","volume":"56","author":"Lima Giacobbo","year":"2019","journal-title":"Mol Neurobiol"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1016\/j.bbi.2020.02.014","article-title":"Peripheral cytokine and fatty acid associations with neuroinflammation in AD and aMCI patients: an exploratory study","volume":"87","author":"Cisbani","year":"2020","journal-title":"Brain Behav Immun"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1951923\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:48:57Z","timestamp":1790830137000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1951923\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":32,"alternative-id":["10.3389\/fnut.2026.1951923"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1951923","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"1951923"}}