{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:07:32Z","timestamp":1788934052465,"version":"build-2803163510"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>\n                    The gut microbiota can metabolize vitamin A and may thereby alleviate symptoms of dry eye disease.\n                    <jats:italic>Bifidobacterium breve<\/jats:italic>\n                    CCFM1489 was investigated, a commensal strain capable of converting vitamin A (VA) into retinoic acid (RA), in a benzalkonium chloride-induced DED mouse model. The results demonstrated that CCFM1489 alleviated dry eye symptoms, as evidenced by reduced fluorescein sodium staining of the cornea, improved corneal and conjunctival histopathology. These effects were accompanied by reducing oxidative stress and inflammation whilst elevating systemic RA levels. Integration of gut metagenomic and faecal\/serum metabolomic analyses provided preliminary insights into the underlying mechanisms. CCFM1489 reshaped the gut microbial composition and structure, increasing the abundance of specific taxa, including\n                    <jats:italic>Parabacteroides goldsteinii<\/jats:italic>\n                    and\n                    <jats:italic>Lactiplantibacillus plantarum<\/jats:italic>\n                    , that were associated with metabolic improvements. Functional shifts indicated enhanced microbial VA metabolism and modulation of host\u2013microbiota pathways. Collectively, CCFM1489 regulates gut microbiota involved in VA metabolism and represents a promising microbiota-targeted strategy for ameliorating dry eye disease.\n                  <\/jats:p>","DOI":"10.3389\/fnut.2026.1956357","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:57:16Z","timestamp":1788933436000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Bifidobacterium breve alleviates dry eye disease by regulating gut microbiota and vitamin A metabolism"],"prefix":"10.3389","volume":"13","author":[{"given":"Liming","family":"Huang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Jiangnan University","place":["Wuxi, Jiangsu, China"]},{"name":"School of Food Science and Technology, Jiangnan University","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinni","family":"Sun","sequence":"additional","affiliation":[{"name":"Dong-E-E-Jiao Co., Ltd.","place":["Liaocheng, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gao","family":"Tian","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Jiangnan University","place":["Wuxi, Jiangsu, China"]},{"name":"School of Food Science and Technology, Jiangnan University","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunwen","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Jiangnan University","place":["Wuxi, Jiangsu, China"]},{"name":"School of Food Science and Technology, Jiangnan University","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Li","sequence":"additional","affiliation":[{"name":"Dong'e Ejiao Health Industry Technology Co., Ltd.","place":["Liaocheng, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueying","family":"Ma","sequence":"additional","affiliation":[{"name":"Dong'e Ejiao Health Industry Technology Co., Ltd.","place":["Liaocheng, Shandong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Jiangnan University","place":["Wuxi, Jiangsu, China"]},{"name":"School of Food Science and Technology, Jiangnan University","place":["Wuxi, Jiangsu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangming","family":"Pei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Food Science and Resources, Jiangnan 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