{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:52:26Z","timestamp":1791359546811,"version":"4.3.1"},"reference-count":77,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:00:00Z","timestamp":1791331200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:p>Prenatal depression is a prevalent complication during pregnancy that not only adversely affects maternal mental health and elevates the risk of postpartum depression but also has enduring implications for offspring development. Alterations in the host metabolome and gut microbiome have been linked to the onset and progression of depression; however, the biological mechanisms underlying the association between maternal mood disorders and fetal brain development remain inadequately understood. Recent studies have associated prenatal depression and psychological stress with alterations in the maternal gut microbiota, microbial metabolism, and immune signaling. However, most human evidence remains observational, and it remains unclear whether these microbial alterations precede depressive symptoms, arise as a consequence of depression or psychological stress, or act as intermediate factors within the maternal gut\u2013brain axis. These findings offer novel strategies for the prevention and treatment of threats to maternal-fetal health. This article systematically reviews recent advancements in research concerning the \u201cmicrobiota-gut-brain\u201d axis in the context of maternal-fetal health. It investigates the roles and mechanisms of gut microbiota through preclinical and clinical studies, assesses the feasibility of potential therapeutic strategies, and suggests directions for future research. The aim is to provide a theoretical foundation for interventions targeting maternal-fetal health in cases of prenatal depression.<\/jats:p>","DOI":"10.3389\/fnut.2026.1958794","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:18:57Z","timestamp":1791357537000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The role of maternal gut microbiota in prenatal depression and offspring neurodevelopment"],"prefix":"10.3389","volume":"13","author":[{"given":"Qiushuang","family":"Jia","sequence":"first","affiliation":[{"name":"Department of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]},{"name":"ZhiHe Innovation Hub, Ningbo Key Laboratory of Human Microbiome and Precision Medicine, Zhejiang-Australia Joint Laboratory on Human Microbiome Research, Central Laboratory of the First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqian","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]},{"name":"ZhiHe Innovation Hub, Ningbo Key Laboratory of Human Microbiome and Precision Medicine, Zhejiang-Australia Joint Laboratory on Human Microbiome Research, Central Laboratory of the First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]},{"name":"ZhiHe Innovation Hub, Ningbo Key Laboratory of Human Microbiome and Precision Medicine, Zhejiang-Australia Joint Laboratory on Human Microbiome Research, Central Laboratory of the First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huilin","family":"Yang","sequence":"additional","affiliation":[{"name":"ZhiHe Innovation Hub, Ningbo Key Laboratory of Human Microbiome and Precision Medicine, Zhejiang-Australia Joint Laboratory on Human Microbiome Research, Central Laboratory of the First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]},{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Chen","sequence":"additional","affiliation":[{"name":"ZhiHe Innovation Hub, Ningbo Key Laboratory of Human Microbiome and Precision Medicine, Zhejiang-Australia Joint Laboratory on Human Microbiome Research, Central Laboratory of the First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]},{"name":"Department of Obstetrics and Gynecology, The First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liemin","family":"Ruan","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongze","family":"Lou","sequence":"additional","affiliation":[{"name":"Department of Psychosomatic Medicine, The First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]},{"name":"ZhiHe Innovation Hub, Ningbo Key Laboratory of Human Microbiome and Precision Medicine, Zhejiang-Australia Joint Laboratory on Human Microbiome Research, Central Laboratory of the First Affiliated Hospital of Ningbo University","place":["Ningbo, Zhejiang, China"]},{"name":"School of Brain Science and Brain Medicine, Zhejiang University","place":["Hangzhou, Zhejiang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"101595","DOI":"10.1016\/j.lanepe.2026.101595","article-title":"Prenatal maternal depression and child behavioural and developmental outcomes: an individual participant data meta-analysis in 76,514 children from the EU child cohort network","volume":"63","author":"Hermans","year":"2026","journal-title":"Lancet Reg Health Eur"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"105787","DOI":"10.1016\/j.psyneuen.2022.105787","article-title":"Associations of maternal prenatal emotional symptoms with neurodevelopment of children and the neonatal meconium microbiota: a prospective cohort 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