{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:04:49Z","timestamp":1789452289894,"version":"build-2803163510"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"College Students\u2019 Innovative Entrepreneurial Training Plan Program","award":["202510601033"],"award-info":[{"award-number":["202510601033"]}]},{"name":"National Natural Science Foundation of Guangxi","award":["2024GXNSFBA010194"],"award-info":[{"award-number":["2024GXNSFBA010194"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Nutr."],"abstract":"<jats:sec>\n                    <jats:title>Background and aim<\/jats:title>\n                    <jats:p>High-fat diet (HFD)-induced metabolic dysfunction is associated with disturbances in gut microbial composition and hepatic lipid metabolism. This study investigated the metabolic effects of Alcalase-hydrolyzed casein peptides after simulated gastrointestinal digestion (MCPs) in HFD-fed mice and explored their potential association with gut microbiota and fecal metabolic alterations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      MCP supplementation attenuated body weight gain, improved serum lipid profiles, and alleviated hepatic steatosis and injury in HFD-fed mice. In the colon, MCPs ameliorated histological damage and suppressed the mRNA and protein expression of pro-inflammatory cytokines, including IL-6, IL-1\u03b2, and TNF-\u03b1. Gut microbiota analysis revealed increased relative abundances of\n                      <jats:italic>Akkermansia, Bifidobacterium<\/jats:italic>\n                      , and\n                      <jats:italic>Lactobacillus<\/jats:italic>\n                      and reduced abundance of\n                      <jats:italic>Desulfovibrio<\/jats:italic>\n                      following MCP supplementation. Fecal metabolomics identified alterations in bile acid- and lipid metabolism-related signatures, including increased levels of tauroursodeoxycholic acid (TUDCA) and reduced arachidonic acid metabolism-related metabolites. In the liver, MCPs downregulated. SREBP-1c\/ACC\/GPAT1 lipogenic signaling and enhanced Nrf2\/HO-1-associated antioxidant responses. Correlation analysis revealed associations between microbial-metabolic alterations and host metabolic phenotypes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Collectively, MCPs may alleviate HFD-induced metabolic dysfunction by modulating gut microbiota-associated metabolic profiles and improving intestinal and hepatic metabolic responses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnut.2026.1960914","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:35:34Z","timestamp":1789450534000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Alcalase-hydrolyzed casein peptides after simulated gastrointestinal digestion alleviate high-fat diet-induced metabolic dysfunction in mice"],"prefix":"10.3389","volume":"13","author":[{"given":"Ling","family":"Mo","sequence":"first","affiliation":[{"name":"Wuzhou Red Cross Hospital","place":["Wuzhou, Guangxi, China"]},{"name":"School of Public Health, Guilin Medical University","place":["Guilin, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaochao","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Public Health, Guilin Medical University","place":["Guilin, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health, Guilin Medical University","place":["Guilin, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanli","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Public Health, Guilin Medical University","place":["Guilin, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingping","family":"Deng","sequence":"additional","affiliation":[{"name":"School of Public Health, Guilin Medical University","place":["Guilin, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongming","family":"Yu","sequence":"additional","affiliation":[{"name":"Wuzhou Red Cross Hospital","place":["Wuzhou, Guangxi, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyun","family":"Zeng","sequence":"additional","affiliation":[{"name":"School of Public Health, Guilin Medical University","place":["Guilin, Guangxi, China"]},{"name":"Guangxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University","place":["Guilin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"6949","DOI":"10.3390\/ijms22136949","article-title":"Mitochondrial lipid homeostasis at the crossroads of liver and heart diseases","volume":"22","author":"Dabravolski","year":"2021","journal-title":"Int J Mol Sci"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.3390\/molecules30153103","article-title":"Research Progress and prospects of flavonoids in the treatment of hyperlipidemia: a narrative review","volume":"30","author":"Chen","year":"2025","journal-title":"Molecules"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"119354","DOI":"10.1016\/j.foodres.2026.119354","article-title":"Resveratrol and tomato pectin synergistically ameliorated metabolic disorder in high-fat-diet mice through the microbiota-gut-liver axis","volume":"237","author":"Zong","year":"2026","journal-title":"Food Res Int"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"118448","DOI":"10.1016\/j.foodres.2026.118448","article-title":"Lacto-N-triose II alleviates metabolic dysfunction-associated Steatotic liver disease via microbiota-dependent citrulline biosynthesis","volume":"228","author":"Chen","year":"2026","journal-title":"Food Res Int"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"134232","DOI":"10.1016\/j.foodchem.2022.134232","article-title":"Phenolics from noni (Morinda citrifolia L.) fruit alleviate obesity in high fat diet-fed mice via modulating the gut microbiota and mitigating intestinal damage","volume":"402","author":"Wang","year":"2023","journal-title":"Food Chem"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"108863","DOI":"10.1016\/j.jnutbio.2021.108863","article-title":"Probiotics alleviate autoimmune hepatitis in mice through modulation of gut microbiota and intestinal permeability","volume":"98","author":"Liu","year":"2021","journal-title":"J Nutr Biochem"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.jhep.2017.11.014","article-title":"Lipotoxicity and the gut-liver axis in NASH pathogenesis","volume":"68","author":"Marra","year":"2017","journal-title":"J Hepatol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/s41575-018-0011-z","article-title":"The gut-liver axis and the intersection with the microbiome","volume":"15","author":"Tripathi","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.fshw.2021.02.026","article-title":"Effect of fermented bee pollen on metabolic syndrome in high-fat diet-induced mice","volume":"10","author":"Yan","year":"2021","journal-title":"Food Sci Human Wellness"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"110360","DOI":"10.1016\/j.foodres.2021.110360","article-title":"Pu-erh tea ameliorates obesity and modulates gut microbiota in high fat diet fed mice","volume":"144","author":"Ye","year":"2021","journal-title":"Food Res Int"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"4904","DOI":"10.1039\/D5FO00841G","article-title":"Dietary methionine restriction ameliorates atherosclerosis by remodeling the gut microbiota in apolipoprotein E-knockout mice","volume":"16","author":"Yang","year":"2025","journal-title":"Food Funct"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"8070","DOI":"10.1039\/D4FO01844C","article-title":"Aloe polysaccharides ameliorate obesity-associated cognitive dysfunction in high-fat diet-fed mice by targeting the gut microbiota and intestinal barrier integrity","volume":"15","author":"Mo","year":"2024","journal-title":"Food Funct"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.metabol.2017.02.003","article-title":"Berberine-induced bioactive metabolites of the gut microbiota improve energy metabolism","volume":"70","author":"Wang","year":"2017","journal-title":"Metabolism"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet\u2013induced obesity and diabetes in mice","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"9149","DOI":"10.1039\/D4FO02106A","article-title":"Analysis of the liver\u2013gut axis including metabolomics and intestinal flora to determine the protective effects of kiwifruit seed oil on CCl4-induced acute liver injury","volume":"15","author":"Hao","year":"2024","journal-title":"Food Funct"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"157404","DOI":"10.1016\/j.phymed.2025.157404","article-title":"Integrative gut microbiota and metabolomics reveals the mechanism of chicory extract in improving metabolic dysfunction-associated steatotic liver disease via gut-liver axis","volume":"148","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"100990","DOI":"10.1016\/j.crfs.2025.100990","article-title":"Role of gut microbiota and fecal metabolites in the protective effect of soybean pulp-rich diet against estrogen-induced cholestasis in rats","volume":"10","author":"Wang","year":"2025","journal-title":"Curr Res Food Sci"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1111\/jgh.14526","article-title":"Tauroursodeoxycholic acid attenuates colitis-associated colon cancer by inhibiting nuclear factor kappaB signaling","volume":"34","author":"Kim","year":"2018","journal-title":"J Gastroenterol Hepatol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"154911","DOI":"10.1016\/j.phymed.2023.154911","article-title":"Nervonic acid improves liver inflammation in a mouse model of Parkinson's disease by inhibiting proinflammatory signaling pathways and regulating metabolic pathways","volume":"117","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"23790","DOI":"10.1021\/acs.jafc.4c02671","article-title":"Rice protein peptides alleviate alcoholic liver disease via the PPAR\u03b3 signaling pathway: through liver metabolomics and gut microbiota analysis","volume":"72","author":"Tian","year":"2024","journal-title":"J Agric Food Chem"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"117333","DOI":"10.1016\/j.foodres.2025.117333","article-title":"Identification and exploration of sleep-enhancing peptides from goat milk casein by peptidomics and virtual screening","volume":"221","author":"Mo","year":"2025","journal-title":"Food Res Int"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.foodres.2025.117399","article-title":"Bioactive peptides and functional activity analysis in lactic acid bacteria-fermented donkey milk","volume":"221","author":"Ning","year":"2010","journal-title":"Food Res Int"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"129374","DOI":"10.1016\/j.foodchem.2021.129374","article-title":"Simulated gastrointestinal digestion of camel and bovine casein hydrolysates: identification and characterization of novel anti-diabetic bioactive peptides","volume":"353","author":"Mudgil","year":"2021","journal-title":"Food Chem"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3390\/foods14030535","article-title":"Bioactive peptides from Milk proteins with antioxidant, anti-inflammatory, and antihypertensive activities","volume":"14","author":"Borges","year":"2025","journal-title":"Foods"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"104730","DOI":"10.1016\/j.fbio.2024.104730","article-title":"The cholesterol-lowering effects and mechanisms of novel milk casein-derived peptides in hyperlipidemia and hypercholesterol mice","volume":"61","author":"Wu","year":"2024","journal-title":"Food Biosci"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.foodchem.2018.12.011","article-title":"Comparative characterization of protein and lipid fractions from camel and cow milk, their functionality, antioxidant and antihypertensive properties upon simulated gastro-intestinal digestion","volume":"279","author":"Maqsood","year":"2019","journal-title":"Food Chem"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"9250015","DOI":"10.26599\/FSHW.2024.9250015","article-title":"Goat casein hydrolysates alleviated insomnia in mice via modulating the level of neurotransmitters and the composition of gut microbiota","volume":"14","author":"Mo","year":"2025","journal-title":"Food Sci Human Wellness"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"e2200638","DOI":"10.1002\/mnfr.202200638","article-title":"Porphyra haitanensis polysaccharides attenuates blood lipid via gut-liver Axis in diet-induced high-fat Mesocricetus auratus through multiple integrated omics","volume":"67","author":"Zeng","year":"2023","journal-title":"Mol Nutr Food Res"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"153292","DOI":"10.1016\/j.phymed.2020.153292","article-title":"Huang-qi san ameliorates hyperlipidemia with obesity rats via activating brown adipocytes and converting white adipocytes into brown-like adipocytes","volume":"78","author":"Hao","year":"2020","journal-title":"Phytomedicine"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"9641","DOI":"10.1002\/fsn3.4529","article-title":"Identification of whey protein-derived anti-obesity peptides through 3T3-L1 adipocyte differentiation assay","volume":"12","author":"Hirose","year":"2024","journal-title":"Food Sci Nutr"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1021\/acs.jafc.2c05535","article-title":"Dietary methionine restriction promotes fat browning and attenuates hepatic lipid accumulation in high-choline-fed mice associated with the improvement of thyroid function","volume":"71","author":"Yang","year":"2023","journal-title":"J Agric Food Chem"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"104255","DOI":"10.1016\/j.fbio.2024.104255","article-title":"Fecal microbiota transplantation from methionine-restricted diet mouse donors reduces fat deposition in obese mice by remodeling the gut microbiota","volume":"59","author":"Yang","year":"2024","journal-title":"Food Biosci"},{"key":"ref33","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.tem.2014.03.002","article-title":"Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance","volume":"25","author":"Arner","year":"2014","journal-title":"Trends Endocrinol Metab"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.diabet.2008.04.001","article-title":"Impact of visceral adipose tissue on liver metabolism","volume":"34","author":"Lafontan","year":"2008","journal-title":"Diabetes Metab"},{"key":"ref35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2019\/8075163","article-title":"Protective effects of aqueous extract of Baillonella toxisperma stem bark on dexamethasone-induced insulin resistance in rats","volume":"2019","author":"Wego","year":"2019","journal-title":"Adv Pharmacol Sci"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"104859","DOI":"10.1016\/j.jff.2021.104859","article-title":"Nuciferine prevents hepatic steatosis associated with improving intestinal mucosal integrity, mucus-related microbiota and inhibiting TLR4\/MyD88\/NF-\u03baB pathway in high-fat induced rats","volume":"88","author":"Fan","year":"2022","journal-title":"J Funct Foods"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"45176","DOI":"10.1038\/srep45176","article-title":"Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia","volume":"7","author":"Xue","year":"2017","journal-title":"Sci Rep"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"5286","DOI":"10.1021\/acs.jafc.5c13455","article-title":"Polyphenol-rich coffee leaf extract alleviates high-fat diet-induced intestinal barrier dysfunction through modulation of barrier integrity, enterohepatic Axis, and gut microbiota","volume":"74","author":"Mei","year":"2026","journal-title":"J Agric Food Chem"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"106512","DOI":"10.1016\/j.psj.2026.106512","article-title":"Bifidobacterium supplementation ameliorates LPS-induced immune stress and intestinal barrier dysfunction in goslings","volume":"105","author":"Zhang","year":"2026","journal-title":"Poult Sci"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"108386","DOI":"10.1016\/j.fbio.2026.108386","article-title":"Sheep milk protects while cow milk exacerbates DSS-induced colitis by differentially modulating the Akkermansia-short chain fatty acids-barrier axis","volume":"77","author":"Ahmad","year":"2026","journal-title":"Food Biosci"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"2430541","DOI":"10.1080\/19490976.2024.2430541","article-title":"Infant feces-derived Lactobacillus gasseri FWJL-4 mitigates experimental necrotizing enterocolitis via acetate production","volume":"16","author":"Pan","year":"2024","journal-title":"Gut Microbes"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.lfs.2017.09.014","article-title":"Sulfate-reducing bacteria stimulate gut immune responses and contribute to inflammation in experimental colitis","volume":"189","author":"Figliuolo","year":"2017","journal-title":"Life Sci"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13099-024-00632-w","article-title":"Desulfovibrio vulgaris caused gut inflammation and aggravated DSS-induced colitis in C57BL\/6 mice model","volume":"16","author":"Huang","year":"2024","journal-title":"Gut Pathogens"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41580-022-00572-w","article-title":"Metabolites as signalling molecules","volume":"24","author":"Baker","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1093420","DOI":"10.3389\/fmicb.2022.1093420","article-title":"The 7-\u03b1-dehydroxylation pathway: An integral component of gut bacterial bile acid metabolism and potential therapeutic target","volume":"13","author":"Wise","year":"2023","journal-title":"Front Microbiol"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"4971","DOI":"10.1038\/s41467-019-12896-x","article-title":"Theabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism","volume":"10","author":"Huang","year":"2019","journal-title":"Nat Commun"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1186\/s40104-025-01284-9","article-title":"Advances in understanding the role of gut microbiota in fat deposition and lipid metabolism","volume":"16","author":"Zhong","year":"2025","journal-title":"J Anim Sci Biotechnol"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3389\/fcimb.2018.00013","article-title":"Impact of the gut microbiota on intestinal immunity mediated by tryptophan metabolism","volume":"8","author":"Gao","year":"2018","journal-title":"Front Cell Infect Microbiol"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1124\/dmd.115.063677","article-title":"Aryl hydrocarbon receptor activity of tryptophan metabolites in young adult mouse Colonocytes","volume":"43","author":"Cheng","year":"2015","journal-title":"Drug Metab Dispos"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.3390\/pharmaceutics14071500","article-title":"Research Progress and potential applications of spermidine in ocular diseases","volume":"14","author":"Han","year":"2022","journal-title":"Pharmaceutics"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"5409","DOI":"10.1007\/s10787-025-01843-6","article-title":"Alphonsea elliptica (Hook.F. And Thomson) methanol leaves extract obliterates inflammatory processes in LPS-induced human plasma","volume":"33","author":"Attiq","year":"2025","journal-title":"Inflammopharmacology"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"4915","DOI":"10.1038\/s41598-020-61821-6","article-title":"Impaired bile acid metabolism with defectives of mitochondrial-tRNA taurine modification and bile acid taurine conjugation in the taurine depleted cats","volume":"10","author":"Miyazaki","year":"2020","journal-title":"Sci Rep"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1080\/02772248.2021.1892113","article-title":"Protective effects of taurine against hepatotoxicity induced by pharmaceuticals and environmental chemicals","volume":"103","author":"Nikkhah","year":"2021","journal-title":"Toxicol Environ Chem"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"112029","DOI":"10.1016\/j.fct.2021.112029","article-title":"Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPAR\u03b1\/SREBP-1c\/FAS\/GPAT\/AMPK signal pathway","volume":"149","author":"Zhang","year":"2021","journal-title":"Food Chem Toxicol"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1785178","DOI":"10.3389\/fendo.2026.1785178","article-title":"Lipid metabolism-MAFLD crosstalk: mechanisms and therapy","volume":"17","author":"Li","year":"2026","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"1600439","DOI":"10.3389\/fphar.2025.1600439","article-title":"Gut microbiota modulation by traditional Chinese medicine: a translational strategy for metabolic dysfunction-associated steatotic liver disease","volume":"16","author":"Zhou","year":"2025","journal-title":"Front Pharmacol"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"117169","DOI":"10.1016\/j.ecoenv.2024.117169","article-title":"T-2 toxin triggers lipid metabolism disorder and oxidative stress in liver of ducks","volume":"286","author":"An","year":"2024","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"119038","DOI":"10.1016\/j.foodres.2026.119038","article-title":"Dietary methionine restriction ameliorates ulcerative colitis in mice: a role for the H2S and short-chain fatty acids balance via gut microbiota remodeling","volume":"233","author":"Yang","year":"2026","journal-title":"Food Res Int"}],"container-title":["Frontiers in Nutrition"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1960914\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:35:36Z","timestamp":1789450536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnut.2026.1960914\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":58,"alternative-id":["10.3389\/fnut.2026.1960914"],"URL":"https:\/\/doi.org\/10.3389\/fnut.2026.1960914","relation":{},"ISSN":["2296-861X"],"issn-type":[{"value":"2296-861X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,15]]},"article-number":"1960914"}}