{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:35:15Z","timestamp":1760985315322},"reference-count":30,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2015.00124","type":"journal-article","created":{"date-parts":[[2015,6,9]],"date-time":"2015-06-09T14:19:06Z","timestamp":1433859546000},"source":"Crossref","is-referenced-by-count":4,"title":["Single-Cell Phenotypic Characterization of Human Pituitary GHomas and Non-Functioning Adenomas Based on Hormone Content and Calcium Responses to Hypothalamic Releasing Hormones"],"prefix":"10.3389","volume":"5","author":[{"given":"Laura","family":"Senovilla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00c3\u00ada","family":"N\u00c3\u00ba\u00c3\u00b1ez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00c3\u00a9 Mar\u00c3\u00ada","family":"de Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"de Luis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Garc\u00c3\u00ada-Sancho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Villalobos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2015,6,9]]},"reference":[{"issue":"1","key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0889-8529(05)70055-4","article-title":"Pathogenesis of pituitary tumors","volume":"28","author":"Melmed","year":"1999","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"6","key":"B2","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1210\/jcem-71-6-1427","article-title":"Clonal origin of pituitary adenomas","volume":"71","author":"Herman","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"B3","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1023\/A:1012945129981","article-title":"Classification of pituitary adenomas","volume":"54","author":"Kovacs","year":"2001","journal-title":"J Neurooncol"},{"issue":"6","key":"B4","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1210\/edrv.19.6.0350","article-title":"The cytogenesis and pathogenesis of pituitary adenomas","volume":"19","author":"Asa","year":"1998","journal-title":"Endocr Rev"},{"issue":"2","key":"B5","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1007\/s12672-010-0014-x","article-title":"Silent corticogonadotrophs adenomas: clinical and cellular characteristics and long-term outcomes","volume":"1","author":"Cooper","year":"2010","journal-title":"Horm Cancer"},{"issue":"1","key":"B6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1620\/tjem.127.53","article-title":"Abnormal growth hormone responses to CB-154 and thyrotropin-releasing hormone (TRH) in patients with acromegaly","volume":"127","author":"Hanew","year":"1979","journal-title":"Tohoku J Exp Med"},{"issue":"4","key":"B7","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1530\/acta.0.1220443","article-title":"Paradoxical growth hormone response to thyrotropin-releasing hormone in acromegaly. Clinical correlations and prognostic value","volume":"22","author":"De Marinis","year":"1990","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"4","key":"B8","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1507\/endocrj1954.39.355","article-title":"Differences in pathological findings and growth hormone responses in patients with growth hormone-producing pituitary adenoma","volume":"39","author":"Bando","year":"1992","journal-title":"Endocrinol Jpn"},{"issue":"6","key":"B9","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1507\/endocrj.52.763","article-title":"Mechanisms of TRH-induced GH release (paradoxical response) in human somatotroph adenoma cells","volume":"52","author":"Okinaga","year":"2005","journal-title":"Endocr J"},{"issue":"4","key":"B10","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1530\/acta.0.1090467","article-title":"Growth hormone releasing factor induces prolactin secretion in acromegalic patients but not in normal subjects","volume":"109","author":"Losa","year":"1985","journal-title":"Acta Endocrinol (Copenh)"},{"issue":"2\u00e2\u20ac\u201c3","key":"B11","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0306-4530(82)90010-5","article-title":"Growth hormone, prolactin and thyrotropin responses to gonadotropin-releasing hormone in depressed patients and healthy volunteers","volume":"7","author":"Amsterdam","year":"1982","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"B12","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/S0015-0282(16)55552-6","article-title":"Effect of human corticotropin-releasing hormone on gonadotropin secretion in cycling and postmenopausal women","volume":"58","author":"Fischer","year":"1992","journal-title":"Fertil Steril"},{"issue":"3","key":"B13","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1080\/019131299281635","article-title":"Ultrastructural and immunoelectron microscopic study of three unusual plurihormonal pituitary adenomas","volume":"23","author":"Vidal","year":"1999","journal-title":"Ultrastruct Pathol"},{"issue":"3","key":"B14","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1159\/000125127","article-title":"Response of a GH- and TSH-secreting pituitary adenoma to a somatostatin analogue (SMS 201-995): evidence that GH and TSH coexist in the same cell and secretory granules","volume":"49","author":"Malarkey","year":"1989","journal-title":"Neuroendocrinology"},{"issue":"5","key":"B15","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1210\/jcem-42-5-857","article-title":"Human mixed somatotrophic and lactotrophic pituitary adenomas","volume":"42","author":"Corenblum","year":"1976","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"B16","first-page":"605","article-title":"Human growth hormone and prolactin secreting pituitary adenomas analyzed by in situ hybridization","volume":"134","author":"Lloyd","year":"1989","journal-title":"Am J Pathol"},{"issue":"9","key":"B17","doi-asserted-by":"publisher","first-page":"4545","DOI":"10.1210\/jc.2004-0072","article-title":"Multifunctional cells in human pituitary adenomas: implications for paradoxical secretion and tumorigenesis","volume":"89","author":"Senovilla","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"B18","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1113\/jphysiol.2003.040758","article-title":"Multifunctional cells of mouse anterior pituitary reveal a striking sexual dimorphism","volume":"549","author":"N\u00c3\u00ba\u00c3\u00b1ez","year":"2003","journal-title":"J Physiol (Lond)"},{"issue":"25","key":"B19","doi-asserted-by":"publisher","first-page":"14132","DOI":"10.1073\/pnas.94.25.14132","article-title":"Multi-responsiveness of single anterior pituitary cells to hypothalamic releasing hormones: a cellular basis for paradoxical secretion","volume":"94","author":"Villalobos","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"B20","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1210\/endo.130.2.1733736","article-title":"Calcium signalling in single growth hormone-releasing factor-responsive pituitary cells","volume":"130","author":"Cuttler","year":"1992","journal-title":"Endocrinology"},{"issue":"5043","key":"B21","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1126\/science.1734523","article-title":"GnRH-induced Ca2+ oscillations and rhythmic hyperpolarizations of pituitary gonadotropes","volume":"255","author":"Tse","year":"1992","journal-title":"Science"},{"issue":"12","key":"B22","doi-asserted-by":"publisher","first-page":"5205","DOI":"10.1210\/endo.137.12.8940336","article-title":"Thyrotropin-releasing hormone-induced intracellular calcium responses in individual rat lactotrophs and thyrotrophs","volume":"137","author":"Ashworth","year":"1996","journal-title":"Endocrinology"},{"issue":"5","key":"B23","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1096\/fasebj.10.5.8621065","article-title":"Functional glutamate receptors in a subpopulation of anterior pituitary cells","volume":"10","author":"Villalobos","year":"1996","journal-title":"FASEB J"},{"issue":"3","key":"B24","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1006\/jtbi.2000.2135","article-title":"CRH-induced electrical activity and calcium signalling in pituitary corticotrophs","volume":"206","author":"Shorten","year":"2000","journal-title":"J Theor Biol"},{"issue":"3","key":"B25","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s00424-004-1337-7","article-title":"Phenotypic characterization of multifunctional somatotropes, mammotropes and gonadotropes of the mouse anterior pituitary","volume":"449","author":"Villalobos","year":"2004","journal-title":"Pfl\u00c3\u00bcgers Arch"},{"issue":"5","key":"B26","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1111\/j.1365-2265.1994.tb01833.x","article-title":"Abnormal response of luteinizing hormone beta subunit to thyrotrophin-releasing hormone in patients with non-functioning pituitary adenoma","volume":"41","author":"Gil-del-Alamo","year":"1994","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"7","key":"B27","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S1043-2760(02)00613-6","article-title":"Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis","volume":"13","author":"Frohman","year":"2002","journal-title":"Trends Endocrinol Metab"},{"issue":"6","key":"B28","doi-asserted-by":"publisher","first-page":"E1166","DOI":"10.1152\/ajpendo.00194.2004","article-title":"Anterior pituitary thyrotropes are multifunctional cells","volume":"287","author":"Villalobos","year":"2004","journal-title":"Am J Physiol"},{"issue":"11","key":"B29","doi-asserted-by":"publisher","first-page":"4627","DOI":"10.1210\/en.2005-0836","article-title":"Changes in expression of hypothalamic releasing hormone receptors in individual rat anterior pituitary cells during maturation, puberty and senescence","volume":"146","author":"Senovilla","year":"2005","journal-title":"Endocrinology"},{"issue":"5","key":"B30","doi-asserted-by":"publisher","first-page":"2159","DOI":"10.1210\/en.2007-1030","article-title":"Rapid changes in anterior pituitary cell phenotypes in male and female mice after acute cold stress","volume":"149","author":"Senovilla","year":"2008","journal-title":"Endocrinology"}],"container-title":["Frontiers in Oncology"],"original-title":[],"deposited":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T11:45:04Z","timestamp":1566819904000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fonc.2015.00124\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,9]]},"references-count":30,"URL":"https:\/\/doi.org\/10.3389\/fonc.2015.00124","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,9]]}}}