{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:17:58Z","timestamp":1792631878257,"version":"4.5.0"},"reference-count":38,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2015.00207","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T09:30:13Z","timestamp":1443432613000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":48,"title":["Detection of Circulating Tumor Cells in Non-Small Cell Lung Cancer"],"prefix":"10.3389","volume":"5","author":[{"given":"Annkathrin","family":"Hanssen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Loges","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Pantel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Wikman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3322\/caac.21262","article-title":"Global cancer statistics, 2012","volume":"65","author":"Torre","year":"2015","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/nrclinonc.2014.104","article-title":"Acquired resistance to TKIs in solid tumours: learning from lung cancer","volume":"11","author":"Camidge","year":"2014","journal-title":"Nat Rev Clin Oncol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nrc3820","article-title":"Challenges in circulating tumour cell research","volume":"14","author":"Alix-Panabieres","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"B4","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1038\/nrclinonc.2013.253","article-title":"Molecular analysis of circulating tumour cells-biology and biomarkers","volume":"11","author":"Krebs","year":"2014","journal-title":"Nat Rev Clin Oncol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1373\/clinchem.2012.194258","article-title":"Circulating tumor cells: liquid biopsy of cancer","volume":"59","author":"Alix-Panabieres","year":"2013","journal-title":"Clin Chem"},{"key":"B6","doi-asserted-by":"publisher","first-page":"6403","DOI":"10.1158\/1078-0432.CCR-05-1769","article-title":"Circulating tumor cells versus imaging \u2013 predicting overall survival in metastatic breast cancer","volume":"12","author":"Budd","year":"2006","journal-title":"Clin Cancer Res"},{"key":"B7","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1007\/s11864-013-0253-5","article-title":"Clinical utility of circulating tumour cell detection in non-small-cell lung cancer","volume":"14","author":"Fusi","year":"2013","journal-title":"Curr Treat Options Oncol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15252\/emmm.201303698","article-title":"Biology, detection, and clinical implications of circulating tumor cells","volume":"7","author":"Joosse","year":"2015","journal-title":"EMBO Mol Med"},{"key":"B9","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1126\/scitranslmed.3005109","article-title":"The identification and characterization of breast cancer CTCs competent for brain metastasis","volume":"5","author":"Zhang","year":"2013","journal-title":"Sci Transl Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1038\/nm.3600","article-title":"Tumorigenicity and genetic profiling of circulating tumor cells in small-cell lung cancer","volume":"20","author":"Hodgkinson","year":"2014","journal-title":"Nat Med"},{"key":"B11","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1126\/science.1253533","article-title":"Cancer therapy. Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility","volume":"345","author":"Yu","year":"2014","journal-title":"Science"},{"key":"B12","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1158\/0008-5472.CAN-14-2613","article-title":"Establishment and characterization of a cell line from human circulating colon cancer cells","volume":"75","author":"Cayrefourcq","year":"2015","journal-title":"Cancer Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1373\/clinchem.2012.188557","article-title":"Heterogeneity of epidermal growth factor receptor status and mutations of KRAS\/PIK3CA in circulating tumor cells of patients with colorectal cancer","volume":"59","author":"Gasch","year":"2013","journal-title":"Clin Chem"},{"key":"B14","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1126\/scitranslmed.3009095","article-title":"Hematogenous dissemination of glioblastoma multiforme","volume":"6","author":"Muller","year":"2014","journal-title":"Sci Transl Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e78070","DOI":"10.1371\/journal.pone.0078070","article-title":"Prognostic significance of circulating tumor cells in non-small-cell lung cancer patients: a meta-analysis","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"B16","doi-asserted-by":"publisher","first-page":"6897","DOI":"10.1158\/1078-0432.CCR-04-0378","article-title":"Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases","volume":"10","author":"Allard","year":"2004","journal-title":"Clin Cancer Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"271","DOI":"10.3389\/fonc.2014.00271","article-title":"A multicenter pilot study examining the role of circulating tumor cells as a blood-based tumor marker in patients with extensive small-cell lung cancer","volume":"4","author":"Huang","year":"2014","journal-title":"Front Oncol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1200\/JCO.2010.28.7045","article-title":"Evaluation and prognostic significance of circulating tumor cells in patients with non-small-cell lung cancer","volume":"29","author":"Krebs","year":"2011","journal-title":"J Clin Oncol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1002\/ijc.25819","article-title":"Detection of circulating tumor cells as a prognostic factor in patients undergoing radical surgery for non-small-cell lung carcinoma: comparison of the efficacy of the CellSearch Assay and the isolation by size of epithelial tumor cell method","volume":"129","author":"Hofman","year":"2011","journal-title":"Int J Cancer"},{"key":"B20","doi-asserted-by":"publisher","first-page":"6980","DOI":"10.1158\/1078-0432.CCR-09-1095","article-title":"Circulating tumor cell as a diagnostic marker in primary lung cancer","volume":"15","author":"Tanaka","year":"2009","journal-title":"Clin Cancer Res"},{"key":"B21","first-page":"3339","article-title":"Clinical significance of circulating tumor cells and free DNA in non-small cell lung cancer","volume":"32","author":"Isobe","year":"2012","journal-title":"Anticancer Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"131","DOI":"10.3727\/096504012X13473664562583","article-title":"Relationship of circulating tumor cells to the effectiveness of cytotoxic chemotherapy in patients with metastatic non-small-cell lung cancer","volume":"20","author":"Hirose","year":"2012","journal-title":"Oncol Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"e103883","DOI":"10.1371\/journal.pone.0103883","article-title":"Assessment of EGFR mutations in circulating tumor cell preparations from NSCLC patients by next generation sequencing: toward a real-time liquid biopsy for treatment","volume":"9","author":"Marchetti","year":"2014","journal-title":"PLoS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1016\/j.lungcan.2011.07.003","article-title":"Circulating tumor cell detection in advanced non-small cell lung cancer patients by multi-marker QPCR analysis","volume":"75","author":"Devriese","year":"2012","journal-title":"Lung Cancer"},{"key":"B25","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1200\/JCO.2010.33.3716","article-title":"Clinical significance and molecular characteristics of circulating tumor cells and circulating tumor microemboli in patients with small-cell lung cancer","volume":"30","author":"Hou","year":"2012","journal-title":"J Clin Oncol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s12094-013-1128-8","article-title":"Prognostic significance of circulating tumor cells in advanced non-small cell lung cancer patients treated with docetaxel and gemcitabine","volume":"16","author":"Juan","year":"2014","journal-title":"Clin Transl Oncol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1097\/JTO.0b013e31823c5c16","article-title":"Analysis of circulating tumor cells in patients with non-small cell lung cancer using epithelial marker-dependent and -independent approaches","volume":"7","author":"Krebs","year":"2012","journal-title":"J Thorac Oncol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e67466","DOI":"10.1371\/journal.pone.0067466","article-title":"Size-based isolation of circulating tumor cells in lung cancer patients using a microcavity array system","volume":"8","author":"Hosokawa","year":"2013","journal-title":"PLoS One"},{"key":"B29","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1002\/cncr.28975","article-title":"Tracking viable circulating tumor cells (CTCs) in the peripheral blood of non-small cell lung cancer (NSCLC) patients undergoing definitive radiation therapy: pilot study results","volume":"121","author":"Dorsey","year":"2015","journal-title":"Cancer"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1200\/JCO.2012.44.5932","article-title":"Detection of circulating tumor cells harboring a unique ALK rearrangement in ALK-positive non-small-cell lung cancer","volume":"31","author":"Pailler","year":"2013","journal-title":"J Clin Oncol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3978\/j.issn.2218-6751.2014.03.05","article-title":"Individual profiling of circulating tumor cell composition in patients with non-small cell lung cancer receiving platinum based treatment","volume":"3","author":"Nel","year":"2014","journal-title":"Transl Lung Cancer Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1093\/annonc\/mds137","article-title":"ALK-gene rearrangement: a comparative analysis on circulating tumour cells and tumour tissue from patients with lung adenocarcinoma","volume":"23","author":"Ilie","year":"2012","journal-title":"Ann Oncol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1093\/annonc\/mdv165","article-title":"High level of chromosomal instability in circulating tumor cells of ROS1-rearranged non-small-cell lung cancer","volume":"26","author":"Pailler","year":"2015","journal-title":"Ann Oncol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1056\/NEJMoa0800668","article-title":"Detection of mutations in EGFR in circulating lung-cancer cells","volume":"359","author":"Maheswaran","year":"2008","journal-title":"N Engl J Med"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2965","DOI":"10.1158\/0008-5472.CAN-12-4140","article-title":"Complex tumor genomes inferred from single circulating tumor cells by array-CGH and next-generation sequencing","volume":"73","author":"Heitzer","year":"2013","journal-title":"Cancer Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"6384","DOI":"10.1158\/0008-5472.CAN-13-2030","article-title":"Real-time liquid biopsy in cancer patients: fact or fiction?","volume":"73","author":"Pantel","year":"2013","journal-title":"Cancer Res"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1056\/NEJMoa1213261","article-title":"Analysis of circulating tumor DNA to monitor metastatic breast cancer","volume":"368","author":"Dawson","year":"2013","journal-title":"N Engl J Med"},{"key":"B38","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1126\/scitranslmed.3007094","article-title":"Detection of circulating tumor DNA in early- and late-stage human malignancies","volume":"6","author":"Bettegowda","year":"2014","journal-title":"Sci Transl Med"}],"container-title":["Frontiers in Oncology"],"original-title":[],"deposited":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T13:39:01Z","timestamp":1443793141000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fonc.2015.00207\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,22]]},"references-count":38,"URL":"https:\/\/doi.org\/10.3389\/fonc.2015.00207","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,22]]}}}