{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T23:48:44Z","timestamp":1787615324505,"version":"build-2736575974"},"reference-count":61,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2017.00122","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T07:07:32Z","timestamp":1497856052000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":47,"title":["The Role of Central Neck Lymph Node Dissection in the Management of Papillary Thyroid Cancer"],"prefix":"10.3389","volume":"7","author":[{"given":"Lawrence A.","family":"Shirley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie B.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Phay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"61","DOI":"10.3322\/caac.20107","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J Clin"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2638","DOI":"10.1002\/(SICI)1097-0142(19981215)83:12<2638::AID-CNCR31>3.0.CO;2-1","article-title":"A national cancer data base report on 53,856 cases of thyroid carcinoma treated in the U.S. 1985\u20131995","volume":"839","author":"Hundahl","year":"1998","journal-title":"Cancer"},{"key":"B3","doi-asserted-by":"publisher","first-page":"4043","DOI":"10.1210\/jcem.84.11.6115","article-title":"Immediate cuases of death in thyroid carcinoma: clinicopathological analysis of 161 fatal cases","volume":"84","author":"Kitamura","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.surg.2005.09.013","article-title":"Nodal yield, morbidity, and recurrence after central neck dissection for papillary thyroid carcinoma","volume":"138","author":"Pereira","year":"2005","journal-title":"Surgery"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1245\/s10434-011-1600-z","article-title":"Central lymph node metastasis of unilateral papillary thyroid carcinoma: patterns and factors predictive of nodal metastasis, morbidity, and recurrence","volume":"18","author":"Roh","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"946","DOI":"10.1016\/S0039-6060(03)00424-0","article-title":"Role of preoperative ultrasonography in the surgical management of patients with thyroid cancer","volume":"134","author":"Kouvaraki","year":"2003","journal-title":"Surgery"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1007\/s00268-008-9588-7","article-title":"Diagnostic accuracy of CT and ultrasonography for evaluating metastatic cervical lymph nodes in patients with thyroid cancer","volume":"32","author":"Ahn","year":"2008","journal-title":"World J Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"3590","DOI":"10.1210\/jc.2007-0444","article-title":"Ultrasound criteria of malignancy for cervical lymph nodes in patients followed up for differentiated thyroid cancer","volume":"92","author":"Leboulleux","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"B9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.otot.2011.04.001","article-title":"Central neck dissection","volume":"22","author":"Friedman","year":"2011","journal-title":"Operative Tech Otolaryngol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1089\/thy.2009.0159","article-title":"Consensus statement on the terminology and classification of central neck dissection for thyroid cancer","volume":"19","author":"Carty","year":"2009","journal-title":"Thyroid"},{"key":"B11","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/0002-9343(94)90321-2","article-title":"Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer","volume":"97","author":"Mazzaferri","year":"1994","journal-title":"Am J Med"},{"key":"B12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1177\/000313480507100907","article-title":"The implication of lymph node metastasis on survival in patients with well-differentiated thyroid cancer","volume":"71","author":"Podnos","year":"2005","journal-title":"Am Surg"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.surg.2008.08.034","article-title":"The impact of lymph node involvement on survival in patients with papillary and follicular thyroid carcinoma","volume":"144","author":"Zaydfudim","year":"2008","journal-title":"Surgery"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1210\/jc.2009-0298","article-title":"A vision for the surgical management of papillary thyroid carcinoma: extensive lymph node compartmental dissections and selective use of radioiodine","volume":"94","author":"Mazzaferri","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"B15","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1089\/thy.2011.0317","article-title":"American Thyroid Association design and feasibility of a prospective randomized controlled trial of prophylactic central lymph node dissection for papillary thyroid carcinoma","volume":"22","author":"Carling","year":"2012","journal-title":"Thyroid"},{"key":"B16","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1089\/thy.2011.0121","article-title":"In papillary thyroid cancer, preoperative central neck ultrasound detects only macroscopic surgical disease, but negative findings predict excellent long-term regional control and survival","volume":"22","author":"Moreno","year":"2012","journal-title":"Thyroid"},{"key":"B17","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1002\/lary.21227","article-title":"Efficacy of preoperative neck ultrasound in the detection of cervical lymph node metastasis from thyroid cancer","volume":"121","author":"Hwang","year":"2011","journal-title":"Laryngoscope"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/j.surg.2016.06.042","article-title":"Routine central lymph node dissection with total thyroidectomy for papillary thyroid cancer potentially minimizes level VI recurrence","volume":"160","author":"Hall","year":"2016","journal-title":"Surgery"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1048","DOI":"10.1016\/j.surg.2011.09.003","article-title":"A multicenter cohort study of total thyroidectomy and routine central lymph node dissection for cN0 papillary thyroid cancer","volume":"150","author":"Popadich","year":"2011","journal-title":"Surgery"},{"key":"B20","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.surg.2011.02.004","article-title":"Prophylactic central lymph node dissection for clinically node-negative papillary thyroid microcarcinoma: influence on serum thyroglobulin level, recurrence rate, and postoperative complications","volume":"151","author":"So","year":"2012","journal-title":"Surgery"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1016\/j.surg.2006.08.001","article-title":"Routine ipsilateral level VI lymphadenectomy reduces postoperative thyroglobulin levels in papillary thyroid cancer","volume":"140","author":"Sywak","year":"2006","journal-title":"Surgery"},{"key":"B22","doi-asserted-by":"publisher","first-page":"3477","DOI":"10.1245\/s10434-013-3125-0","article-title":"A meta-analysis of the effect of prophylactic central compartment neck dissection on locoregional recurrence rates in patients with papillary thyroid cancer","volume":"20","author":"Wang","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1002\/lary.22162","article-title":"Routine central neck dissection in differentiated thyroid carcinoma: a systematic review and meta-analysis","volume":"122","author":"Shan","year":"2012","journal-title":"Laryngoscope"},{"key":"B24","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1089\/thy.2012.0011","article-title":"Complications of central neck dissection in patients with papillary thyroid carcinoma: results of a study on 1087 patients and review of literature","volume":"22","author":"Giordano","year":"2012","journal-title":"Thyroid"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1210\/jc.2014-3825","article-title":"Prophylactic central compartment lymph node dissection in papillary thyroid carcinoma: clinical implications derived from the first prospective randomized controlled single institution study","volume":"100","author":"Viola","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1210\/jc.2008-1931","article-title":"Prophylactic lymph node dissection for papillary thyroid cancer less than 2 cm: implications for radioiodine treatment","volume":"94","author":"Bonnet","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1016\/j.surg.2010.09.019","article-title":"Influence of prophylactic central lymph node dissection on postoperative thyroglobulin levels and radioiodine treatment in papillary thyroid cancer","volume":"148","author":"Hughes","year":"2010","journal-title":"Surgery"},{"key":"B28","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1001\/jamaoto.2015.0786","article-title":"Long-term results of observation vs prophylactic selective level VI neck dissection for papillary thyroid carcinoma at a cancer center","volume":"141","author":"Ywata de Carvalho","year":"2015","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1245\/s10434-010-1470-9","article-title":"Central compartment reoperation for recurrent\/persistent differentiated thyroid cancer: patterns of recurrence, morbidity, and prediction of postoperative hypocalcemia","volume":"18","author":"Roh","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1001\/archsurg.2010.9","article-title":"Central neck lymph node dissection for papillary thyroid cancer: comparison of complication and recurrence rates in 295 initial dissections and reoperations","volume":"145","author":"Shen","year":"2010","journal-title":"Arch Surg"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/j.surg.2009.10.024","article-title":"Does failure to perform prophylactic level VI node dissection leave persistent disease detectable by ultrasonography in patients with low-risk papillary carcinoma of the thyroid?","volume":"146","author":"Monchik","year":"2009","journal-title":"Surgery"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1016\/j.surg.2013.04.035","article-title":"Observation of clinically negative central compartment lymph nodes in papillary thyroid carcinoma","volume":"154","author":"Nixon","year":"2013","journal-title":"Surgery"},{"key":"B33","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1097\/MLG.0b013e31815ae3e4","article-title":"Regional metastases in well-differentiated thyroid carcinoma: pattern of spread","volume":"118","author":"Yanir","year":"2008","journal-title":"Laryngoscope"},{"key":"B34","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1742-1241.2002.tb11247.x","article-title":"Cervical metastasis in papillary carcinoma of the thyroid: a histopathological study","volume":"56","author":"Coatesworth","year":"2002","journal-title":"Int J Clin Pract"},{"key":"B35","first-page":"333","article-title":"Neck dissection for surgical treatment of lymph node metastasis in papillary thyroid carcinoma","volume":"16","author":"Ducci","year":"1997","journal-title":"J Exp Clin Cancer Res"},{"key":"B36","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1002\/hed.23391","article-title":"Tumor location-dependent skip lateral cervical lymph node metastasis in papillary thyroid cancer","volume":"36","author":"Lee","year":"2014","journal-title":"Head Neck"},{"key":"B37","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/BF00353765","article-title":"Prognostic significance and surgical management of locoregional lymph node metastases in papillary thyroid cancer","volume":"18","author":"Scheumann","year":"1994","journal-title":"World J Surg"},{"key":"B38","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1177\/000313480306900303","article-title":"Greater local recurrence occurs with \u201cberry-picking\u201d than neck dissection in thyroid cancer","volume":"69","author":"Musacchio","year":"2003","journal-title":"Am Surg"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1002\/lary.20236","article-title":"Systematic review and meta-analysis of the adverse effects of thyroidectomy combined with central neck dissection as compared with thyroidectomy alone","volume":"119","author":"Chisholm","year":"2009","journal-title":"Laryngoscope"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1089\/thy.2009.0110","article-title":"American Thyroid Association (ATA) guidelines taskforce on thyroid nodules and differentiated thyroid cancer: revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer","volume":"19","author":"Cooper","year":"2009","journal-title":"Thyroid"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"261","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"B42","doi-asserted-by":"crossref","unstructured":"Thyroid Carcinoma (Version 1.2016)2016","DOI":"10.1155\/2016\/4863405"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/cen.12515","article-title":"Guidelines for the management of thyroid cancer","volume":"81","author":"Perros","year":"2014","journal-title":"Clin Endocrinol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00423-013-1152-8","article-title":"Prophylactic central neck disection in papillary thyroid cancer: a consensus report of the European Society of Endocrine Surgeons (ESES)","volume":"399","author":"Sancho","year":"2014","journal-title":"Langenbecks Arch Surg"},{"key":"B45","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00268-010-0832-6","article-title":"Therapeutic strategy for differentiated thyroid carcinoma in Japan based on a newly established guideline managed by Japanese Society of Thyroid Surgeons and Japanese Association of Endocrine Surgeons","volume":"35","author":"Takami","year":"2011","journal-title":"World J Surg"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1210\/jcem.86.4.7407","article-title":"Clinical review 128: current approaches to primary therapy for papillary and follicular thyroid cancer","volume":"86","author":"Mazzaferri","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"B47","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1089\/thy.2015.0429","article-title":"Clinical and pathologic predictors of lymph node metastasis and recurrence in papillary thyroid microcarcinoma","volume":"26","author":"Siddiqui","year":"2016","journal-title":"Thyroid"},{"key":"B48","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1007\/s00268-005-0298-0","article-title":"Sentinel lymph node biopsy may be used to support the decision to perform modified radical neck dissection in differentiated thyroid carcinoma","volume":"30","author":"Dzodic","year":"2006","journal-title":"World J Surg"},{"key":"B49","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1245\/s10434-010-1141-x","article-title":"Sentinel lymph node biopsy for papillary thyroid cancer: 12 years of experience at a single institution","volume":"17","author":"Cunningham","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1868","DOI":"10.1245\/s10434-011-2109-1","article-title":"Clinical efficacy of sentinel lymph node biopsy using methylene blue dye in clinically node-negative papillary thyroid carcinoma","volume":"19","author":"Ji","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e0129304","DOI":"10.1371\/journal.pone.0129304","article-title":"The utility of sentinel lymph node biopsy in papillary thyroid carcinoma with occult lymph nodes","volume":"10","author":"Yan","year":"2015","journal-title":"PLoS One"},{"key":"B52","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1007\/s00405-014-3018-2","article-title":"Value of sentinel lymph node biopsy in papillary thyroid cancer: initial results of a prospective trial","volume":"272","author":"Cabrera","year":"2015","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1586\/era.10.111","article-title":"Role of sentinel lymph node biopsy in thyroid cancer","volume":"10","author":"Roh","year":"2010","journal-title":"Expert Rev Anticancer Ther"},{"key":"B54","doi-asserted-by":"publisher","first-page":"7511","DOI":"10.1158\/1078-0432.CCR-11-1155","article-title":"Role of BRAF in thyroid oncogenesis","volume":"17","author":"Caronia","year":"2011","journal-title":"Clin Cancer Res"},{"key":"B55","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s00268-011-1383-1","article-title":"BRAFV600E mutation is associated with tumor aggressiveness in papillary thyroid cancer","volume":"36","author":"Kim","year":"2012","journal-title":"World J Surg"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1002\/lary.23371","article-title":"Reoperative central compartment dissection for patients with recurrent\/persistent papillary thyroid cancer: efficacy, safety, and association of the BRAF mutation","volume":"122","author":"Tufano","year":"2012","journal-title":"Laryngoscope"},{"key":"B57","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1210\/jc.2003-032050","article-title":"Detection of BRAF mutation on fine needle aspiration biopsy specimens: a new diagnostic tool for papillary thyroid cancer","volume":"89","author":"Xing","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"B58","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1245\/s10434-012-2611-0","article-title":"BRAF V600E mutation independently predicts central compartment lymph node metastasis in patients with papillary thyroid cancer","volume":"20","author":"Howell","year":"2013","journal-title":"Ann Surg Oncol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1089\/thy.2015.0378","article-title":"Association of BRAF V600E mutation and microRNA expression with central lymph node metastases in papillary thyroid cancer: a prospective study from four endocrine surgery centers","volume":"26","author":"Han","year":"2016","journal-title":"Thyroid"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1016\/j.surg.2015.05.016","article-title":"Role of BRAF V600E mutation as an indicator of the extent of thyroidectomy and lymph node dissection in conventional papillary thyroid carcinoma","volume":"158","author":"Kim","year":"2015","journal-title":"Surgery"},{"key":"B61","doi-asserted-by":"publisher","first-page":"2718","DOI":"10.1200\/JCO.2014.55.5094","article-title":"BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence","volume":"32","author":"Xing","year":"2014","journal-title":"J Clin Oncol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fonc.2017.00122\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T15:20:05Z","timestamp":1750346405000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fonc.2017.00122\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,19]]},"references-count":61,"alternative-id":["10.3389\/fonc.2017.00122"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2017.00122","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,19]]},"article-number":"122"}}