{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T10:26:04Z","timestamp":1792664764133,"version":"4.5.0"},"reference-count":23,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2017.00125","type":"journal-article","created":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T23:44:51Z","timestamp":1498175091000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":24,"title":["Presentation, Treatment, and Prognosis of Secondary Melanoma within the Orbit"],"prefix":"10.3389","volume":"7","author":[{"given":"Anna M.","family":"Rose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Cowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Channa N.","family":"Jayasena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Verity","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey E.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,6,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1001\/archopht.1985.01050070063031","article-title":"Intraocular metastases from cutaneous malignant melanoma","volume":"103","author":"de Bustros","year":"1985","journal-title":"Arch Ophthalmol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/0002-9394(67)91300-1","article-title":"Primary malignant melanoma of the skin metastatic to the eye and orbit: report of ten cases and review of the literature","volume":"63","author":"Font","year":"1967","journal-title":"Am J Ophthalmol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/S0161-6420(98)94011-8","article-title":"Cutaneous melanoma metastatic to the vitreous cavity","volume":"105","author":"G\u00fcnd\u00fcz","year":"1998","journal-title":"Ophthalmology"},{"key":"B4","first-page":"591","article-title":"Retinal metastases","volume-title":"Retina","author":"Young","year":"1989"},{"key":"B5","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/eye.1999.60","article-title":"Intraocular metastases of cutaneous malignant melanoma: a case report and review of the literature","volume":"13","author":"Ramaesh","year":"1999","journal-title":"Eye"},{"key":"B6","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/01676830902897470","article-title":"Orbital metastasis: clinical features, management and outcome","volume":"28","author":"Valenzuela","year":"2009","journal-title":"Orbit"},{"key":"B7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/00002341-198804020-00003","article-title":"Tumours metastatic to the orbit","volume":"4","author":"Shields","year":"1988","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/00002341-200109000-00009","article-title":"Cancer metastatic to the orbit: the 2000 Robert M. Curts Lecture","volume":"17","author":"Shields","year":"2001","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0039-6257(90)90045-W","article-title":"Tumours metastatic to the orbit: a changing picture","volume":"35","author":"Goldberg","year":"1990","journal-title":"Surv Ophthalmol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1016\/j.ophtha.2003.05.004","article-title":"Metastatic melanoma in the eye and orbit","volume":"110","author":"Zografos","year":"2003","journal-title":"Ophthalmology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1097\/ICU.0b013e3282c5077c","article-title":"Metastatic tumours of the orbit and ocular adnexa","volume":"18","author":"Ahmad","year":"2007","journal-title":"Curr Opin Ophthalmol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1001\/archopht.1997.01100150136036","article-title":"Metastatic choroidal melanoma to the contralateral orbit 40 years after enucleation","volume":"115","author":"Coupland","year":"1997","journal-title":"Arch Ophthalmol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/S0161-6420(88)33061-7","article-title":"Melanoma metastatic to the orbit","volume":"95","author":"Orcutt","year":"1988","journal-title":"Ophthalmology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S0161-6420(90)32534-4","article-title":"Clinical characteristics of metastatic orbital tumours","volume":"97","author":"Goldberg","year":"1990","journal-title":"Ophthalmology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1001\/archopht.123.12.1639","article-title":"Development of metastatic disease after enrolment in the COMS trials for treatment of choroidal melanoma: Collaborative Ocular Melanoma Study Group Report No. 26","volume":"123","author":"Diener-West","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"B16","first-page":"159","article-title":"Basis for current major therapies for cancer","volume-title":"Clinical Oncology","author":"Yaeger","year":"2000"},{"key":"B17","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1080\/01676830601169189","article-title":"Contralateral orbital melanoma 28 years following enucleation for choroidal melanoma","volume":"26","author":"Connolly","year":"2007","journal-title":"Orbit"},{"key":"B18","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1007\/BF00299157","article-title":"Spontaneous regression of human melanoma\/non-melanoma skin cancer: association with infiltrating CD4+ T cells","volume":"19","author":"Halliday","year":"1995","journal-title":"World J Surg"},{"key":"B19","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1002\/cncr.24724","article-title":"Characteristics associated with early and late melanoma metastases","volume":"116","author":"Brauer","year":"2010","journal-title":"Cancer"},{"key":"B20","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/00002341-199509000-00003","article-title":"Primary and secondary orbital melanomas: a clinical and prognostic study","volume":"11","author":"Polito","year":"1995","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"B21","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1056\/NEJMoa1504030","article-title":"Combined nivolumab and ipilimumab or monotherapy in untreated melanoma","volume":"373","author":"Larkin","year":"2015","journal-title":"N Engl J Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/pcmr.12304","article-title":"Biology of advanced uveal melanoma and next steps for clinical therapeutics","volume":"28","author":"Luke","year":"2015","journal-title":"Pigment Cell Melanoma Res"},{"key":"B23","doi-asserted-by":"publisher","first-page":"553","DOI":"10.4155\/fmc.13.17","article-title":"Hypoxia inducible factor pathway inhibitors as anticancer therapeutics","volume":"5","author":"Burroughs","year":"2013","journal-title":"Future Med Chem"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fonc.2017.00125\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T23:44:51Z","timestamp":1498175091000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fonc.2017.00125\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,23]]},"references-count":23,"alternative-id":["10.3389\/fonc.2017.00125"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2017.00125","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,23]]},"article-number":"125"}}