{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:46:03Z","timestamp":1790304363795,"version":"4.1.0"},"reference-count":46,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Oncol."],"DOI":"10.3389\/fonc.2017.00316","type":"journal-article","created":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T02:44:08Z","timestamp":1513565048000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["Primary Orbital Melanoma: Presentation, Treatment, and Long-term Outcomes for 13 Patients"],"prefix":"10.3389","volume":"7","author":[{"given":"Anna M.","family":"Rose","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Luthert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Channa N.","family":"Jayasena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Verity","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey E.","family":"Rose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.clindermatol.2008.09.010","article-title":"Ocular melanoma: relatively rare but requiring respect","volume":"27","author":"Shields","year":"2009","journal-title":"Clin Dermatol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/S0002-9394(02)02288-2","article-title":"Conjunctival melanoma: is it increasing in the United States?","volume":"135","author":"Yu","year":"2003","journal-title":"Am J Ophthalmol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"22","DOI":"10.4103\/0970-0358.96572","article-title":"Clinicopathological analysis of eyelid malignancies \u2013 a review of 85 cases","volume":"45","author":"Kale","year":"2012","journal-title":"Indian J Plast Surg"},{"key":"B4","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1080\/08820530500353864","article-title":"Cutaneous melanomas of the eyelid","volume":"21","author":"Boulos","year":"2006","journal-title":"Semin Ophthalmol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/j.1442-9071.1986.tb00004.x","article-title":"Malignant melanoma of the eyelid and conjunctiva","volume":"14","author":"Collin","year":"1986","journal-title":"Aust N Z J Ophthalmol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1080\/01676830902897470","article-title":"Orbital metastasis: clinical features, management and outcome","volume":"28","author":"Valenzuela","year":"2009","journal-title":"Orbit"},{"key":"B7","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1097\/00002341-198804020-00003","article-title":"Tumours metastatic to the orbit","volume":"4","author":"Shields","year":"1988","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"B8","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1097\/00002341-200109000-00009","article-title":"Cancer metastatic to the orbit: the 2000 Robert M. Curts Lecture","volume":"17","author":"Shields","year":"2001","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0039-6257(90)90045-W","article-title":"Tumours metastatic to the orbit: a changing picture","volume":"35","author":"Goldberg","year":"1990","journal-title":"Surv Ophthalmol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2245","DOI":"10.1016\/j.ophtha.2003.05.004","article-title":"Metastatic melanoma in the eye and orbit","volume":"110","author":"Zografos","year":"2003","journal-title":"Ophthalmology"},{"key":"B11","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1097\/ICU.0b013e3282c5077c","article-title":"Metastatic tumours of the orbit and ocular adnexa","volume":"18","author":"Ahmad","year":"2007","journal-title":"Curr Opin Ophthalmol"},{"key":"B12","first-page":"53","volume-title":"Diseases of the Orbit: a multidisciplinary approach","author":"Rootman","year":"2003"},{"key":"B13","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1111\/j.1540-9740.2003.01706.x","article-title":"Nevus of Ota: clinical aspects and management","volume":"2","author":"Henry","year":"2003","journal-title":"Skinmed"},{"key":"B14","first-page":"43","volume-title":"Orbital Tumors","author":"Henderson","year":"1994"},{"key":"B15","doi-asserted-by":"publisher","first-page":"379","DOI":"10.4103\/0019-509X.146733","article-title":"Orbital melanoma: recurrence versus primary: a diagnostic dilemma","volume":"51","author":"Mukherjee","year":"2014","journal-title":"Indian J Cancer"},{"key":"B16","doi-asserted-by":"publisher","first-page":"e4","DOI":"10.1097\/SCS.0b013e3182a32e89","article-title":"Primary orbital melanoma combined with giant divided nevus of the eyelid","volume":"25","author":"Ke","year":"2014","journal-title":"J Craniofac Surg"},{"key":"B17","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1055\/s-0033-1350611","article-title":"[A thirty-four-year-old woman with primary orbital melanoma]","volume":"230","author":"Schultheiss","year":"2013","journal-title":"Klin Monbl Augenheilkd"},{"key":"B18","doi-asserted-by":"publisher","first-page":"306","DOI":"10.4103\/0301-4738.109526","article-title":"Orbital malignant melanoma associated with nevus of Ota","volume":"61","author":"Radhadevi","year":"2013","journal-title":"Indian J Ophthalmol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1382","DOI":"10.1001\/archophthalmol.2011.302","article-title":"Primary orbital melanoma with poliosis and a palpable mass","volume":"129","author":"Alsuhaibani","year":"2011","journal-title":"Arch Ophthalmol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1097\/IOP.0b013e31818d1ded","article-title":"Primary malignant melanoma of the orbit in an African-American man","volume":"24","author":"Mahoney","year":"2008","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"B21","first-page":"1799","article-title":"Navigation-assisted resection of a primary extraocular melanoma of the orbit","volume":"27","author":"Friedrich","year":"2007","journal-title":"Anticancer Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/S1808-8694(15)31033-8","article-title":"Primary malignant orbit melanoma","volume":"72","author":"Patroc\u00ednio","year":"2006","journal-title":"Braz J Otorhinolaryngol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1016\/j.ajo.2006.05.050","article-title":"Primary orbital melanoma treated with iodine-125 plaque radiotherapy","volume":"142","author":"De Potter","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"B24","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/01.IOP.0000161716.46032.90","article-title":"Primary orbital melanoma associated with a blue nevus","volume":"21","author":"Odashiro","year":"2005","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"B25","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/j.ophtha.2003.01.002","article-title":"Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery lecture, part 1","volume":"111","author":"Shields","year":"2004","journal-title":"Ophthalmology"},{"key":"B26","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1001\/archopht.122.2.287","article-title":"Primary orbital melanoma associated with an occult episcleral nevus","volume":"122","author":"Mandeville","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1001\/archopht.122.1.118","article-title":"Aggressive primary orbital melanoma in a young white man with no predisposing ocular features","volume":"122","author":"Delaney","year":"2004","journal-title":"Arch Ophthalmol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1076\/orbi.22.4.265.17249","article-title":"Loss of antigen-processing molecules in primary orbital melanoma","volume":"22","author":"Krishnakumar","year":"2003","journal-title":"Orbit"},{"key":"B29","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1076\/orbi.22.4.257.17242","article-title":"Expression of HLA class I, beta(2)-microglobulin and HLA class II antigens in primary orbital melanoma","volume":"22","author":"Krishnakumar","year":"2003","journal-title":"Orbit"},{"key":"B30","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1076\/0167-6830(200003)19:1;1-Z;FT021","article-title":"Primary orbital melanoma associated with oculodermal melanocytosis","volume":"19","author":"Kor\u00e1nyi","year":"2000","journal-title":"Orbit"},{"key":"B31","doi-asserted-by":"publisher","first-page":"16","DOI":"10.12968\/eyed.2014.16.3.16","article-title":"Primary orbital melanoma masquerading as vascular anomalies","volume":"16","author":"Lee","year":"2002","journal-title":"Eye (Lond)"},{"key":"B32","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1002\/1096-911X(200008)35:2<142::AID-MPO14>3.0.CO;2-N","article-title":"Primary orbital melanoma in a child","volume":"35","author":"Ijiri","year":"2000","journal-title":"Med Pediatr Oncol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/S0161-6420(96)30585-X","article-title":"Primary orbital melanomas","volume":"103","author":"Tellada","year":"1996","journal-title":"Ophthalmology"},{"key":"B34","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1136\/bjo.77.3.187","article-title":"Necrotic orbital melanoma arising de novo","volume":"77","author":"Shields","year":"1993","journal-title":"Br J Ophthalmol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/00002341-199509000-00003","article-title":"Primary and secondary orbital melanomas: a clinical and prognostic study","volume":"11","author":"Polito","year":"1995","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1130","DOI":"10.1001\/archopht.1990.01070100086040","article-title":"Primary orbital melanoma associated with orbital melanocytosis","volume":"108","author":"Rice","year":"1990","journal-title":"Arch Ophthalmol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1136\/bjo.73.5.388","article-title":"Primary malignant melanoma of the orbit arising in a cellular blue naevus","volume":"73","author":"L\u00f6ffler","year":"1989","journal-title":"Br J Ophthalmol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1136\/bjo.79.12.1146","article-title":"A case of primary orbital melanoma treated by local excision","volume":"79","author":"Elibol","year":"1995","journal-title":"Br J Ophthalmol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1080\/01676830.2017.1279657","article-title":"Orbital melanoma masquerading as a \u201cgalloping haemangioma\u201d","volume":"36","author":"Lorenzano","year":"2017","journal-title":"Orbit"},{"key":"B40","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1111\/ceo.12809","article-title":"Visual outcomes and late complications in paediatric orbital rhabdomyosarcoma","volume":"45","author":"Eade","year":"2017","journal-title":"Clin Exp Ophthalmol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"304","DOI":"10.3109\/08820538.2016.1154175","article-title":"Tumor characteristics, genetics, management, and the risk of metastasis in uveal melanoma","volume":"31","author":"Nichols","year":"2016","journal-title":"Semin Ophthalmol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.jcjo.2012.03.038","article-title":"Uveal melanoma prognostication: from lesion size and cell type to molecular class","volume":"47","author":"Gill","year":"2012","journal-title":"Can J Ophthalmol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/j.1755-148X.2012.00979.x","article-title":"The genetics of uveal melanoma: an emerging framework for targeted therapy","volume":"25","author":"Harbour","year":"2012","journal-title":"Pigment Cell Melanoma Res"},{"key":"B44","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s40364-015-0040-5","article-title":"BAP1 hereditary cancer predisposition syndrome: a case report and review of literature","volume":"3","author":"Klebe","year":"2015","journal-title":"Biomark Res"},{"key":"B45","doi-asserted-by":"publisher","first-page":"125","DOI":"10.3389\/fonc.2017.00125","article-title":"Presentation, treatment, and prognosis of secondary melanoma within the orbit","volume":"7","author":"Rose","year":"2017","journal-title":"Front Oncol"},{"key":"B46","first-page":"134","article-title":"Metastatic choroidal melanoma to the contralateral orbit 40 years after enucleation","volume":"115","author":"Coupland","year":"1997","journal-title":"Acrh Ophthalmol"}],"container-title":["Frontiers in Oncology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fonc.2017.00316\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T02:44:11Z","timestamp":1513565051000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fonc.2017.00316\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,18]]},"references-count":46,"alternative-id":["10.3389\/fonc.2017.00316"],"URL":"https:\/\/doi.org\/10.3389\/fonc.2017.00316","relation":{},"ISSN":["2234-943X"],"issn-type":[{"value":"2234-943X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,18]]},"article-number":"316"}}